NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.

Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.

U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Oxidatively Induced Damage to DNA: Potential Role of Single-Wall Carbon Nanotubes at the Molecular Level

Published

Author(s)

Elijah J. Petersen, Xiaomin X. Tu, M Miral Dizdar, Ming Zheng, Bryant C. Nelson

Abstract

Ultrasonication is a physical process known to generate abundant levels of oxygen-derived species such as hydroxyl radicals, hydrogen atoms, and hydrogen peroxide. When used to process DNA solutions, these highly reactive hydroxyl radicals can react with DNA to generate strand breaks and a multiplicity of oxidatively modified DNA bases. Oxidatively induced damage to DNA bases has been well-studied and the reaction mechanisms have been resolved. Gas chromatography-mass spectrometry (GC-MS) methodologies have been developed to both qualitatively and quantitatively measure the DNA lesions. Here, we investigated DNA base damage in (ATT)14 and (GT)20 oligomers from ultrasonication in the presence and absence of single-wall carbon nanotubes (SWCNTs). We found that the overall level of DNA damage is reduced in the presence of SWCNTs, particularly for DNA lesions formed by one-electron reduction of intermediate radicals.
Proceedings Title
Nanotech 2013
Conference Dates
May 12-16, 2013
Conference Location
Washington, DC
Pub Type
Conferences

Download Paper

Local Download
Environmental health and Nanotechnology

Citation

Petersen, E. , Tu, X. , , M. , Zheng, M. and Nelson, B. (2013), Oxidatively Induced Damage to DNA: Potential Role of Single-Wall Carbon Nanotubes at the Molecular Level, Nanotech 2013, Washington, DC, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=913561 (Accessed October 10, 2025)

Issues

If you have any questions about this publication or are having problems accessing it, please contact [email protected].

Created May 13, 2013, Updated February 19, 2017
Was this page helpful?