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Using Single Particle ICP-MS as a Tool for Understanding Metallic Nanoparticle Transformation during Nanotoxicity Assays

Published

Author(s)

Monique E. Johnson, Shannon Hanna, Antonio R. Montoro Bustos, Bryant C. Nelson, Elijah J. Petersen, Lee L. Yu

Abstract

The advent of engineered nanoparticles (ENPs) and their increased use has remarkably improved the performance of basic materials and consumer products, but has also increased the potential for ENP release into the environment. Technical procedures, more accurate and specific than those for routine chemical analysis, are needed for characterization and quantification of ENPs at environmentally relevant concentrations in nanotoxicology studies. Single particle inductively coupled plasma mass spectrometry (sp-ICP-MS) has emerged as a technique potentially capable of measuring ENPs in aqueous media at the pg L-1 range. The work presented here establishes a method for employing sp-ICP-MS toward the characterization of ENPs following their exposure to a model organism, Caenorhabditis elegans. Sample preparation, ICP-MS analysis, data processing, particulate transport efficiency evaluation, and critical calculations are discussed.
Proceedings Title
Nanotech Conference Technical Proceedings
Conference Dates
June 15-18, 2014
Conference Location
Washington, DC
Conference Title
Nanotech Conference 2014

Keywords

Single particle ICP-MS, C. elegans, nanomaterial characterization, gold nanoparticles

Citation

Johnson, M. , Hanna, S. , Montoro, A. , Nelson, B. , Petersen, E. and Yu, L. (2014), Using Single Particle ICP-MS as a Tool for Understanding Metallic Nanoparticle Transformation during Nanotoxicity Assays, Nanotech Conference Technical Proceedings, Washington, DC, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=915946 (Accessed July 27, 2021)
Created July 1, 2014, Updated February 19, 2017