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Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage



Elijah J. Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson


Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair of oxidatively-induced DNA damage (DNA lesions) in living systems. The National Institute of Standards and Technology has established a comprehensive research program focused on identifying mechanisms of DNA damage caused by commercially relevant engineered nanoparticles (NPs) using high resolution mass spectrometry for the quantification of oxidatively-induced DNA damage. We present results from a recently published study on the genotoxicity of National Institute of Standards and Technology (NIST) standard reference material (SRM) gold nanoparticles using isotope dilution liquid chromatography /mass spectrometry analysis.
Proceedings Title
Nanotech 2013
Conference Dates
May 12-16, 2013
Conference Location
Washington, DC


Petersen, E. , Marquis, B. , Jaruga, P. , , M. and Nelson, B. (2013), Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage, Nanotech 2013, Washington, DC, [online], (Accessed May 19, 2024)


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Created May 13, 2013, Updated February 19, 2017