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Bioscience

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Displaying 676 - 700 of 1221

How well do you know your MATES???

December 1, 2011
Author(s)
Joy P. Dunkers
There is a group that quietly goes about the business of advancing the areas of tissue engineering and regenerative medicine. I say quietly because their work, while impactful, is not well known outside of government circles. How well do you know your

EVALUATION OF A MICROWAVE-ASSISTED METAL-LABELING STRATEGY FOR QUANTIFICATION OF PEPTIDES VIA RPLC-ICP-MS AND THE METHOD OF STANDARD ADDITIONS

November 26, 2011
Author(s)
Steven J. Christopher, Eric L. Kilpatrick, Lee L. Yu, William C. Davis, blakely adair
NIST has performed preliminary research on applying a calibration methodology based on the method of standard additions to the quantification of lanthanide-labeled peptides via reverse-phase liquid chromatography coupled to inductively coupled plasma mass

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution

November 7, 2011
Author(s)
Illarion V. Turko, Natalia Gorlatova, Kinlin L. Chao, Lipika Ray, Rawan Araj, Andrey Galkin, John Moult, Osnat Herzberg
Macrophage Stimulating Protein (MSP) is the ligand of RON receptor tyrosine kinase. MSP binding to RON activates a signaling pathway that plays a dual role in inflammation, initially stimulating macrophage chemotaxis and phagocytosis, but also changing

The Latest and Greatest NIST PCR-based DNA Profiling Standard: Updates and Status of Candidate Standard Reference Material (SRM) 2391c

November 1, 2011
Author(s)
Margaret C. Kline, Carolyn R. Steffen, Jamie L. Almeida, Erica L. Romsos, Michael D. Coble, John M. Butler
Standard Reference Material 2391c (SRM 2391c) PCR-based DNA Profiling Standard is the third renewal of this SRM, originally released in 1995. SRM 2391c consists of 6 candidate components labeled A through F. Components A through D are supplied as genomic

Morphological Changes Driven by Nanofibrous Scaffolds Induce Marrow Stromal Cell Osteogenesis

October 11, 2011
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Christopher K. Tison, Girish Kumar, Patrick S. Pine, Marc L. Salit, Jennifer H. McDaniel, Marian F. Young
Cells are sensitive to tissue scaffold architecture and these cell-material interactions drive cell functions critical in tissue regeneration. Results presented here demonstrate that nanofiber scaffolds force primary human bone marrow stromal cells (hBMSCs

Controlled transport of superparamagnetic beads with spin-valves

October 7, 2011
Author(s)
Wendy R. Altman, John M. Moreland, Stephen E. Russek, Bruce W. Han, Victor M. Bright
Trapping, release, and transport of individual or ensembles of 2.8 υm superparamagnetic beads functionalized with streptavidin were demonstrated using an addressable and non-volatile array of spin-valve (SV) traps integrated into a microfluidic channel

Segmentation and Cell Tracking of Breast Cancer Cells

September 26, 2011
Author(s)
Adele P. Peskin, Daniel J. Hoeppner, Christina H. Stuelten
We describe a new technique to segment and track the cell images of a breast cancer cell line in order to study cell migration and metastasis. Within each image cell phenotypes vary widely, ranging from very bright completely bounded cells to barely

Synthetic spike-in standards for RNA-seq experiments

August 31, 2011
Author(s)
Marc L. Salit, Lichun Jiang, Felix Schlesinger, Brian Oliver, Carrie Davis, Yu Zhang, Renhua Li, Thomas R. Gingeras
High-throughput sequencing of cDNA (RNA-seq) is a widely deployed transcriptome profiling and annotation technique, but questions about the performance of different protocols and platforms remain. We used a newly developed pool of 96 synthetic RNAs with

Hyperspectral Imaging and Analysis of Single Erythrocytes

August 12, 2011
Author(s)
Ji Y. Lee, Matthew L. Clarke, Fuyuki Tokumasu, John F. Lesoine, David W. Allen, Robert C. Chang, Maritoni A. Litorja, Jeeseong Hwang
We report a hyperspectral imaging and analysis technique to resolve unique physico-chemical characteristics of subcellular substances in single erythrocytes. We constructed a microscope system installed with a spectral light engine capable of controlling

Cell Adhesion to Borate Glasses by Colloidal Probe Microscopy

August 1, 2011
Author(s)
Sheldon M. Wiederhorn, Carl G. Simon Jr., Young-Hun Chae
The adhesion of Osteoblast-like cells to silicate and borate glasses was measured using colloidal probe microscopy in a cell growth medium. The probe consisted of silicate and borate glass spheres, 25 µm to 50 µm in diameter, attached to the tip of an

Stable isotope-labeling of DNA repair proteins, and their purification and characterization

July 1, 2011
Author(s)
M Miral Dizdar, Pawel Jaruga, Prasad T. Reddy, Bryant C. Nelson, Mark S. Lowenthal
Reduced DNA repair capacity is associated with increased risk for a variety of disease processes including carcinogenesis. Thus, DNA repair proteins have the potential to be used as important predictive, prognostic and therapeutic biomarkers in cancer and

Negative Regulation of STAT3-mediated Cellular Respiration by SirT1

June 7, 2011
Author(s)
Lili Wang, Hua-Jun He, Michel Bernier, Rajib K. Paul, Alejandro Martin-Montalvo, Morten Scheibye-Knudsen, Shaoming Song, Sean M. Armour, Vilhelm A. Bohr, Yaping Zong, David A. Sinclair, Rafael de Cabo
In mammals, the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) is regulated by the deacetylase SirT1. However, whether the newly described non-genomic actions of STAT3 toward mitochondrial oxidative phosphorylation
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