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Bioscience

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Displaying 676 - 700 of 1242

Designing Microarrays Phantoms for Hyperspectral Imaging Validation

May 9, 2012
Author(s)
Matthew L. Clarke, Ji Y. Lee, Daniel V. Samarov, David W. Allen, Maritoni A. Litorja, Ralph Nossal, Jeeseong Hwang
The simple design of custom-tailored microarrays for the characterization of hyperspectral imaging systems and analysis methods for biologically relevant samples. Individual and mixtures of dyes were printed on microscope slides and imaged by a

Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D

May 1, 2012
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Alison M. Kraigsley, Joachim Kohn, Durgadas Bolikal
Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematically

Osteoblast Response to Serum Protein Adsorption in 3D Polymer Scaffolds

May 1, 2012
Author(s)
Carl G. Simon Jr., Girish Kumar, Kaushik Chatterjee, Stevephen Hung
Protein adsorption is known to direct biological response to biomaterials and is important in determining cellular response in tissue scaffolds. In this study we investigated the effect of adsorbed serum proteins on cell attachment and proliferation in

Uncertainty in RECIST as a measure of volume for lung nodules and liver malignoma

April 27, 2012
Author(s)
Zachary H. Levine, Adam L. Pintar, John G. Hagedorn, Charles D. Fenimore, Claus P. Heussel
The authors investigate the extent to which the RESPONSE Evaluation Criateria in Solid Tumors (RECIST) can predict tumor volumes and changes in volume using clinical data. The data presented are a reanalysis of data acquired in other studies, including the

Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance

April 26, 2012
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Anna L. Seager, Ume K. Shah, Jane M. Mikhail, Shareen H. Doak, George E. Johnson, Paul L. Carmichael, Sharon J. Scott, Andrew D. Scott, Gareth J. Jenkins
Oxidative stress contributes to many disease aetiologies including ageing, neurodegeneration, and cancer, partly through DNA damage induction (genotoxicity). Understanding the interactions of free radicals with DNA is fundamental to discern the mutation

Three-dimensional Shape Metrology for Tissue Engineering

April 21, 2012
Author(s)
Joy P. Dunkers, Antonio M. Possolo, Thomas V. Lafarge, Beatriz Pateiro-Lopez, Jeffrey Coles, Carl G. Simon Jr.
The physical and chemical properties of a tissue scaffold influences cell response and therefore the success of the resulting tissue construct. Scaffold structure from nanometers to millimeters can direct cell behavior, from viability to proliferation to

Positively-charged Dimethacrylates to Reduce Bacterial Attachment

March 30, 2012
Author(s)
Nancy J. Lin, Joseph M. Antonucci, Diana N. Zeiger, Sheng Lin-Gibson, Kathy Tang
The widespread incidence of recurrent tooth decay (caries) highlights the need for improved dental restorative materials. Caries are most frequently caused by acid-producing bacterial biofilms. One approach for developing biomaterials with reduced

Tumor Necrosis Factor Interaction with Gold Nanoparticles

March 14, 2012
Author(s)
De-Hao D. Tsai, Sherrie R. Elzey, Frank W. DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael R. Zachariah, Athena M. Keene, Jeffrey D. Clogston, Vincent A. Hackley
We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spectroscopic

The Biological Macromolecule Crystallization Database

March 6, 2012
Author(s)
David Travis Gallagher, Michael Tung
The Biological Macromolecule Crystallization Database (BMCD) is described. The database currently contains 14372 entries with crystallization information for proteins, protein–protein complexes, nucleic acids, nucleic acid–nucleic acid complexes, protein

Challenges in Microbial Sampling in the Indoor Environment

March 1, 2012
Author(s)
Jayne B. Morrow, Autumn S. Downey, Jordan Peccia
This report summarizes the results of the Challenges in Microbial Sampling in the Indoor Environment Workshop held on February 14-15, 2011 at the National Institute of Standards and Technology in Gaithersburg, Maryland.

Freeform Fabricated Scaffolds with Roughened Struts that Enhance both Stem Cell Proliferation and Differentiation by Controlling Cell Shape

March 1, 2012
Author(s)
Girish Kumar, Carl G. Simon Jr., Michael S. Waters, Tanya M. Farooque, Marian F. Young
We demonstrate that imparting freeform fabricated (FFF) scaffolds with surface roughness on their struts enhances osteogenic differentiation of primary human bone marrow stromal cells (hBMSCs) by controlling cell shape. Previous work showed that hBMSCs

Preparation and Value Assignment of Standard Reference Material 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum

January 2, 2012
Author(s)
Jeanice M. Brown Thomas, David L. Duewer, Lane C. Sander, Katherine E. Sharpless, Lorna T. Sniegoski, Michael J. Welch, James H. Yen, Mugenya O. Isaac
Standard Reference Material 968e Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum provides certified values for total retinol, γ- and α-tocopherol; total lutein, total zeaxanthin, total β-cryptoxanthin, total β-carotene, and cholesterol in

New Concepts for Building Vocabulary for Cell Image Ontologies

December 21, 2011
Author(s)
Anne L. Plant, John T. Elliott, Talapady N. Bhat
Background: We present an approach to cell image databasing that is compatible with searching across a global federation of independent image databases. The variety of biological experiments and data that practitioners would like to access and share is

How well do you know your MATES???

December 1, 2011
Author(s)
Joy P. Dunkers
There is a group that quietly goes about the business of advancing the areas of tissue engineering and regenerative medicine. I say quietly because their work, while impactful, is not well known outside of government circles. How well do you know your

EVALUATION OF A MICROWAVE-ASSISTED METAL-LABELING STRATEGY FOR QUANTIFICATION OF PEPTIDES VIA RPLC-ICP-MS AND THE METHOD OF STANDARD ADDITIONS

November 26, 2011
Author(s)
Steven J. Christopher, Eric L. Kilpatrick, Lee L. Yu, William C. Davis, blakely adair
NIST has performed preliminary research on applying a calibration methodology based on the method of standard additions to the quantification of lanthanide-labeled peptides via reverse-phase liquid chromatography coupled to inductively coupled plasma mass

Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution

November 7, 2011
Author(s)
Illarion V. Turko, Natalia Gorlatova, Kinlin L. Chao, Lipika Ray, Rawan Araj, Andrey Galkin, John Moult, Osnat Herzberg
Macrophage Stimulating Protein (MSP) is the ligand of RON receptor tyrosine kinase. MSP binding to RON activates a signaling pathway that plays a dual role in inflammation, initially stimulating macrophage chemotaxis and phagocytosis, but also changing
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