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Projects/Programs

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Metagenomics is a powerful technology combining high-throughput (a.k.a. “next-generation”) sequencing with advanced bioinformatics to identify and quantify mixtures of organisms in a sample. Metagenomics workflows consist of 4 main steps: Sample collection: location, amount, storage, etc. Extraction

Images depicting an advanced analysis of HR-EBSD data

Strain Measurement for Semiconductor Devices and Packages

Ongoing

Strain is a critical parameter that influences both electrical and mechanical failures of devices, however, measuring strain in complex 3D geometries and vanishingly small feature sizes remains a challenge for manufacturers. Data provided by strain measurements can be used to validate computational

Strain Measurement for Semiconductor Devices

Ongoing

Mechanical strain is hugely important to semiconductor devices and packages while also being difficult to measure accurately. Strain is engineered into CMOS channels to improve carrier mobility for higher performance at lower power but is also intrinsically present from manufacturing processes where

Study of Microheterogeneity in Solid Reference Materials

Ongoing

Presently there are a variety of analytical techniques that are served by few or no reference materials due to the small sample sizes they require. NIST currently certifies solid reference materials at or above the 100 mg mass level in most cases with no mention of the effect of using smaller sample

Surrogate protein particle standards

Ongoing

Intended Impact This work will enable industry to obtain accurate, reproducible counts of protein particles, and to differentiate protein particles from other particle types, resulting in greater drug efficacy and safety. Objectives Create a polydisperse suspension of polymer particles that mimic

Synchrotron Resonant Scattering and Diffraction

Ongoing

The Resonant Scattering and Diffraction effort seeks to develop measurements that provide spatial correlations in chemical, electronic, and physical structure in advanced materials. Scattering technology is developed as part of the NIST BNL partnership at the National Synchrotron Light Source II in

Synchrotron X-ray Absorbance Spectroscopy

Ongoing

The Absorbance Spectroscopy effort seeks to develop measurements that provide details of the local chemical, electronic, and physical structure in advanced materials. Spectrometer technology is developed as part of the NIST BNL partnership at the National Synchrotron Light Source II in Upton, NY

Synchrotron X-ray Spectroscopic Imaging

Ongoing

Building off technologies and expertise developed in the Synchrotron X-ray Absorption Spectroscopy project, the Spectroscopic Imaging effort seeks to develop measurements that provide spatial mapping of the local chemical, electronic, and physical structure in advanced materials. Technology is

Synthetic Biology

Ongoing

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the

US TAG for ISO/TC 334: Reference Materials

Ongoing

Get involved: Interested US Stakeholders may participate in the US TAG at no cost. Membership provides access to all ISO/TC 334 and US TAG documents, including standards under development. Please click here to join or renew your membership. Contribute to standards development : Please click here to

Thermoreflectance Thermal Property Measurements for Heterogeneously Integrated Materials and Power Electronics

Ongoing

Thermal conductivity, heat capacity, and interface conductance are fundamental properties that govern semiconductor microelectronic devices, from materials discovery, to design and modeling, thermal management and device performance, and ultimately device reliability and operational lifespan. These

Thin Film Electronics (Archived)

Completed

Today's electronics have reached a point where sheer computation power has yielded to combined form and function as the key driver of large consumer markets. The demand for portable and pervasive electronics with greater functionality promises significant changes over the next decades in how society

Three-Dimensional Nanometer Metrology

Ongoing

Important physical and chemical properties of nanometer scale devices and structures depend on their shape and size. The benefits of nano are already increasing many applications, and are expected to grow significantly. For these applications, measurement accuracy is a fundamental measurement

Time Measurement and Analysis Service (TMAS)

Ongoing

The TMAS meets the requirements of any facility or organization that needs to maintain a high accuracy time standard. TMAS customers include calibration and metrology laboratories, telecommunication providers, instrumentation manufacturers, military installations, defense contractors, government

Time-resolved Emission Microscopy for Circuit Evaluation and Failure Analysis

Ongoing

When a new integrated circuit is fabricated, it is necessary to measure the chip with microscopy techniques such as photon emission microscopy, which look at infrared photons emitted by electrons accelerated in transistor channels. TREM, also referred to as picosecond imaging circuit analysis, is a

Tissue Engineering Measurands

Ongoing

Making a Measurand Chart: A measurand chart can be created for any measurement by writing down all the measurands that occur during the measurement. The panels should not be procedural steps, such as “wash the sample with buffer” or “centrifuge the microfuge tubes”. Consider if the measurement has a

Traceability in Molecular Spectrophotometry

Ongoing

This program, sometimes referred to as the Optical Filters program, has supported the development, certification, and (as specified) recertification of Standard Reference Materials ® (SRMs ®) for the verification of the transmittance (absorbance) and wavelength scales of spectrophotometers in the

Photography of gas cylinder storage facility with cylinders stored horizontally in movable cabinets.

Traceable Calibration Gases: SRMs, NTRMs, and Protocol Gases

Ongoing

The Gas Sensing Metrology Group prepares the highest level gas standards, known as Primary Standard Gas Mixtures based on precise gravimetric methods and accurate purity analysis. These Primary Standards are verified at NIST, stability confirmed through reanalysis over many years, and compared

Transient Flow Facility

Completed

Impact Provide metrological tools and standards supporting the fair trade of hydrogen gas as a vehicle fuel of the future. Objectives Design, construct, and utilize a facility that mimics retail hydrogen fueling station conditions to quantify uncertainties of flow measurement standards and

SRM 3452 certified Seebeck coefficient data

Transport Property Measurements for Semiconductors and Energy Materials

Ongoing

The properties of materials and interfaces that govern reliability, performance, and thermal transport in advanced microelectronic packages are not fully characterized or understood, especially at device length scales wherein properties may differ significantly from bulk or literature values

Ultrafast Spectroscopy to Advance Microelectronics

Ongoing

Continued advancement in microelectronics, including analog and digital electronics, power electronics, optics and photonics, and micromechanics for memory, processing, sensing, and communications as defined by the OSTP “National Strategy on Microelectronics Research,” requires knowledge of material

Understanding Flow Meters

Ongoing

Critical flow venturis (CFVs) are widely used for gas flows of 1 L/min or more, if a significant pressure drop is acceptable. Theoretical discharge coefficient ( Cd): A calculated value of the discharge coefficient allows 0.3% uncertainty from a CFV from a low uncertainty throat diameter measurement

Uniform Unit Pricing: Tools for Consumers to Fight Shrinkflation

Ongoing

What is Unit Pricing? The pricing of goods based on the cost per unit of measure is commonly known as unit pricing. A unit price label often displays the product name and size, the price, the price per unit (e.g., how much you pay per gram, liter, or ounce), and other information. Unit pricing is

Universal Microscopy Standards

Ongoing

Microscopy standards that are available today have inadequate performance characteristics. As device linewidths decrease toward physical limits, the international roadmap of devices and systems (IRDS) has set uncertainty targets by the year 2025. This target is hard to hit, challenging the industry

Jan Konijnenburg Testing Device Thumbnail

USNWG Field Reference Meters: Coriolis Mass Flow Meters

Ongoing

Customers and businesses alike rely on metering systems to monitor and deliver their liquid-based commercial products (including a range of gas and fuels) consistently over time and across a range of locations. Weights and measures officials use several well-acknowledged field test standards to

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