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Chemistry

Analytical chemistry

Projects/Programs

Keyword

Organizational Unit

High-accuracy Laboratory Spectroscopic Measurements of Atmospheric Gases for Monitoring Greenhouse Gases

Ongoing

Climate science increasingly relies on satellite- and ground-based spectrometers for the top-down inventories of atmospheric greenhouse gases, most notably

High-Precision Isotopic Reference Materials

Ongoing

Recent innovative advances in the design and manufacture of isotope ratio mass spectrometers (IRMS) have revolutionized the study of natural and man-induced

Identification, Suitability Testing, and Property Determination from Untargeted Measurements

Ongoing

Many polymeric fluids, including biotherapeutics and fuels, can have unusual physical behavior in solutions, and many applications require detailed knowledge of

Figure with five interlocking puzzle pieces representing different aspects of the measurement process.

Improving High-Performance Inductively-Coupled Plasma Optical Emission Spectrometry (HP-ICP-OES) Through Exact Matching

Ongoing

Using high-performance inductively coupled plasma optical emission spectrometry (HP‑ICP-OES), relative expanded uncertainties on the order of 0.2 % can be

Photograph of a weathered metal surface labeled Danger Toxic Fumes

Instrument Standards for Detection of Hazardous Chemical Vapors

Ongoing

The overarching goal of this project is to develop and disseminate measurement tools to improve the accuracy and reliability of chemical measurements related to

International Comparisons for Chemical Measurements

Ongoing

Because of NIST's role as the National Metrology Institute (NMI) in the U.S., the Chemical Sciences Division's measurement capabilities must be benchmarked

Ion Mobility Spectrometry

Ongoing

Ion mobility spectrometry (IMS) is widely used for national security and law enforcement, placed at key transportation checkpoints such as airports and border

Photograph of a seabird with a spotted turquoise egg.

Isotopes as Environmental Tracers in Biological Specimens

Ongoing

High precision stable isotope ratio measurements are being used in biological specimens to provide new insights into environmental and climate processes and

Macromolecular Architectures

Ongoing

There is always a degree of uncertainty surrounding measurements of polymeric materials, especially complex mixtures with varying distributions in chemistry

Magnetic Sector Secondary Ion Mass Spectrometry

Ongoing

Magnetic sector secondary ion mass spectrometry (SIMS) generates isotopic and elemental information from solid surfaces with depth profiling capabilities to

Measurement Quality in Hydrogen Storage R&D

Ongoing

No existing hydrogen storage material satisfies the Department of Energy (DoE) goal of achieving a commercial hydrogen storage system for competitive hydrogen

Measurement and Sampling Standards

Ongoing

The use of standards is considered a critical component in the assurance of analytical quality, allowing reliable measures of detection limits, accuracy, and

Measurement Techniques for Membranes and Membrane Proteins

Ongoing

Synthetic cell membrane constructs allow the simplification and complete control of a more complicated cellular system, as well as the incorporation of selected

Measurements and Standards for Botanical Dietary Supplements

Ongoing

As part of a multi-year interagency agreement among the National Institute of Standards and Technology (NIST), the National Institutes of Health's Office of

Measurements and Standards for Contaminants in Biological (Human) Materials

Ongoing

For the past 25 years NIST has developed a number of biological fluid and tissue Standard Reference Materials (SRMs) primarily for clinically important analytes

Wordcloud figure with about 25 words including NIST, metabolomics, quality assurance, and measurements.

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Ongoing

The NIST Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program has been created to demonstrate and improve the comparability of

Method Assessment for Non-Targeted Analyses (MANTA) Program

Ongoing

The MANTA Program is an ongoing collaboration with laboratories to increase the comparability and reproducibility of their results using non-targeted analysis

Direct Analysis in Real Time Mass Spectrometry infogram

Methods, Software Tools, and Resources for Forensics Laboratories with DART-MS or other AI-MS Techniques

Ongoing

With increasing backlogs and more complex samples, forensic chemistry laboratories need new technologies that rapidly provide accurate results. Many

pH Metrology

Ongoing

The pH metrology program supports traceability for pH measurements. This traceability rests on primary pH measurements in an ideal electrochemical cell (Harned

Metrology and Standards for Canine Olfactory Detection of Explosives

As part of a multi-year interagency agreement between the Office of Standards of the Department of Homeland Security and NIST, NIST is developing measurement

A micromechanical bulk acoustic resonator that uses phononic crystal tethers to achieve a quality factor approaching the fundamental dissipation limit (fxQ can be as large as 1.2 x 1013 Hz)

Micro- and Nanoelectromechanical Systems

Completed

Microelectromechanical systems (MEMS) are integrated devices with critical applications in sensing, timing, signal processing, and biomedical diagnostics, and

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed

The Micronutrients Measurement Quality Assurance Program (MMQAP) was initiated in 1984 by the National Cancer Institute Division of Cancer Prevention and

Multidimensional Chromatography

Ongoing

Both comprehensive two-dimensional gas chromatography (GCxGC) and comprehensive two-dimensional liquid chromatography (LCxLC) have emerged as powerful tools

Multiplexed "Detectorless" Electrophoresis

Ongoing

The ability to acquire large amounts of high quality data very rapidly is increasingly important for progress in the biological sciences. Capillary

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Ongoing

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

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