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Bioscience

Projects/Programs

Displaying 151 - 175 of 218
Box for NISTCHO in center, vial of NISTCHO to the right

NISTCHO

Ongoing
NISTCHO, a new mammalian cell line of interest to the biopharmaceutical and biomanufacturing communities, is now available from the National Institute of Standards and Technology. This Chinese hamster ovary (CHO) cell line has been engineered by MilliporeSigma to express a non-originator version of
Fish on a ruler to measure length, about 47 cm from head to tail.

Omics Technological Advances in Aquaculture

Ongoing
According to the NOAA Fisheries of the U.S. report, in 2020 U.S. seafood consumption was estimated at ~6B pounds (~2.7 x 109 kg). Of that, 85% is imported and U.S. exports have seen a significant decline. Globally, the U.S. ranked only 18th in aquaculture production (2020). NIST aims to enhance the

Ontologies and Interoperability in Evolutionary Comparative Analysis

Completed
Intended impact Nearly all scientists who regularly use online resources on genes, proteins and genomes make use of comparative data to advance biomedical research. For instance, researchers often make useful inferences by comparing human genes (as well as proteins, reactions, interactions, pathways
schematic

Optical/electrical particle measurement system

Ongoing
Intended Impact The results of this work should provide instrument manufacturers with data, methods, and algorithms for enhancing the clarity and accuracy of information their instruments provide to their customers. Users of these instruments (pharma companies) and regulators, will have better
Optofluidic chip

Optofluidic Cytometry

Ongoing
Flow cytometers are commercial instruments that provide rapid multiparameter measurements of single cells, which makes them indispensable in basic research and clinical studies of diseases and drug therapies. Measurements of cellular attributes can include indicators of cell size and shape and well

Orthogonal Measurements

Ongoing
Definitions: Orthogonal measurements: Measurements that use different physical principles to measure the same property of the same sample with the goal of minimizing method-specific biases and interferences. Complementary measurements: Measurements that corroborate each other to support the same

Pathogen Detection and Identification: The Next Generation of Analyses

Ongoing
Human disease resulting from pathogens represents a tremendous burden on the health care system. Many hospitals have adopted new, rapid polymerase chain reaction (PCR)-based detection systems because the time to diagnose and begin effective treatment has a direct impact on patient survival and

Peptide Mass Spectral Libraries

Ongoing
Intended Impact Modern mass spectrometers used in the field of proteomics are capable of profiling thousands of peptides in a single experiment. Each of these peptides is fragmented to form a mass spectrum. Therefore, interpretation of these mass spectra is a critical step in the experimental

Performance Metrics for Proteomics

Ongoing
Intended Impact Proteomics experiments designed to identify protein markers specific to a particular disease or disease state rely on repeatable identification of proteins within a control set. Repeatability provides statistical assurance that clear differences between two sets (e.g. sick vs
Martin1

Photopolymerization for Biomaterials

Completed
This project responds to priorities of National Institute of Dental and Craniofacial Research (NIDCR/NIH) for oral health by establishing clinical guidance/standards for adequate photocuring of restorative dental composites. Also, this project is intended to advance the knowledge relevant to thermal
Point-of-Care Pharmaceutical Manufacturing

Point-of-Care Pharmaceutical Manufacturing & Precision Medicine

Ongoing
We are employing quality by design (QbD) and risk assessment (cause-and-effect) approaches to investigate production technologies ( e.g., drop on demand or inkjet printing platforms) and appropriate analytical control strategies for point-of-care manufacture of narrow therapeutic index drugs
Materials Extrusion Additive Manufacturing

Polymer Advanced Manufacturing and Rheology

Ongoing
We are measuring the fundamental processes and material parameters that are critical to understanding and furthering polymers-based AM. These efforts will aid the AM ecosystem through better online monitoring capabilities and developing strategies for materials optimization. In situ measurements of

Protein Preservation

Completed
This project is an integral part of a cooperative effort – led by NIST, and partially funded by NIH/ NIBIB – which includes the University of Wisconsin, the University of Colorado, and the University of Connecticut. We use the following approach to develop measurement solutions for biopharmaceutical

Protein rheology measurements

Ongoing
Intended Impact Why does the health-care industry care about rheology and scattering of protein solutions? Operations. Viscosity is a critical and fundamental constitutive input for drug delivery, device design and manufacturing. For example, high viscosity leads to poor syringeability due to high

Prototype Cell Assay Measurement Platform (P-CAMP)

Ongoing
A systematic approach to the development of robust biological assay includes identifying and ranking the sources of variability in an assay protocol. With a focus on mammalian cellular assays, the Prototype Cell Assay Measurement Platform ( P-CAMP) laboratory was designed and built to take advantage

Quantitative, Cell-based Immunofluorescence Assays

Completed
Analysis of signaling events within individual cells with microscopy imaging has several advantages over non-imaging techniques. The principal advantage of imaging cytometry over plate reader assays and even other single cell techniques such as flow cytometry is the potential for collection of

Quantitative Flow Cytometry Measurements

Ongoing
Flow cytometry is an essential tool for: basic biotechnological and immunological research, the clinical discovery of potential therapeutics, development and approval of drugs and devices, disease diagnosis, and therapeutic treatment and monitoring For example, flow cytometry is commonly used in pre
MRI standards

Quantitative MRI

Ongoing
Future directions may focus on multimodal imaging, techniques that use MRI as either a base or as a complimentary technique. Multimodal imaging combines information from two or more imaging modalities such as MRI, computed tomography (CT), positron emission tomography (PET), and ultrasound (US)
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