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Bioscience

Projects/Programs

Displaying 126 - 150 of 217

Mouse Allelic Ladder

Ongoing
What is an allelic ladder? An allelic ladder is a mixture of highly characterized alleles (known size and sequence) that are generated using the same primers as the test samples and are used during capillary electrophoresis for accurate allele call determination. Why is an allelic ladder important
MPXV RGTM wrapped linear insert

Mpox (MPXV) Synthetic DNA PCR Standards

Ongoing
A new material from NIST can aid in the evaluation and development of selected qPCR assays for the mpox virus. We are offering a unit free of charge in exchange for your feedback, which will help us improve and further develop the material. Questions? Contact MPXV-RGTM [at] nist.gov (MPXV-RGTM[at]nist[dot]gov) . NIST supports the
pumpless body cube with four tissues

Multi-Organ Microphysiological Systems

Ongoing
We are developing tissue chips and multi-tissue microphysiological devices that support the culture of multiple tissues with physiologically relevant connections and streams of cell-culture medium. The goal in this project is to construct a device that realistically mimics human metabolism as a

Nanotube Metrology

Completed
Single-wall carbon nanotubes (SWCNTs) are a tubular form of carbon consisting of a single shell of sp2 bonded carbon with a nanometer scale diameter that have many predicted properties superior to other available materials. However, every production technique for SWCNTs produces many different

Next Generation Metrics for Cell-Based Therapies and Regenerative Medicines

Ongoing
The science of human health and disease often includes studies of cells, the smallest unit of biological complexity. Microscopic imaging is an important tool in these studies and can provide morphological and molecular information. Molecular microscopic data is most often collected in a static mode
NIST Biorepository Freezers

The NIST Biorepository

Ongoing
The NBSB was established in 1979 at NIST in Gaithersburg, MD with a pilot project archiving human liver samples associated with collections through the Environmental Protection Agency (EPA). New collaborations and banking projects were established including the National Oceanic and Atmospheric

NIST/EDRN Cancer Biomarker Collaboration

Completed
Our lab is one of the EDRN Biomarker Reference Laboratories working with the EDRN discovery labs to improve the quality of the measurements done on new cancer biomarkers for early detection of cancer and for cancer risk. TECHNICAL APPROACH Evaluate current assays used for detection of cancer
Flow Cytometry Consortium

NIST Flow Cytometry Standards Consortium 

Ongoing
Advances in cell and gene-based therapeutics as well as other regenerative medicine products have increased the need for high quality, robust, and validated measurements for cell characterization. Flow cytometry, including imaging cytometry, has emerged as an important platform due to its ability to

NIST Genome Editing Consortium: Working Group 1 - Specificity Measurements

Ongoing
Genome editing technologies are able to produce DNA sequence changes of a variety of sizes and at a variety of frequencies in a population of edited cells. Having increased confidence in reliably detecting the sequences generated by a genome editing process was a need area identified. Project 1

NIST Genome Editing Consortium: Working Group 2 - Data & Metadata

Ongoing
Develop a metadata schema for genome editing experiments Develop a way of curating and entry that is low burden for user Release control data with linked metadata PROGRESS Phase1 metadata entries and templates completed In process of compiling and testing use cases, user interfaces, and
Genome editing technologies

NIST Genome Editing Consortium

Ongoing
Targeted genome editing , a method used to alter the DNA of living cells at desired locations, is poised to revolutionize science and medicine. To fight diseases, novel genome edited therapeutics, including those for use in regenerative medicine and infectious diseases, are being developed. Many

NIST Genome Editing Lexicon

Ongoing
The definitions are worded with the intention that additional context may be added with supplementary language when they are used. It is also recognized that genome editing is a rapidly evolving biotechnology and additional terms and definitions will be needed as genome editing technologies mature

NIST Genome Editing Program

Ongoing
For genome editing systems to reach their full potential in research and commercial products, new measurement tools, capabilities, and standards must be developed to efficiently implement and assess the performance of these editing technologies, as well as to evaluate the utility of resulting
HER2 SRM Unit and Individual Components

NIST HER2 Genomic DNA Standard Reference Material, SRM® 2373

Ongoing
The amplification of the gene for HER2 occurs in approximately 20 to 25% of breast cancers. The accurate measurement of this biomarker is important for the proper treatment with anti-HER2 therapeutics. Clinical laboratories are beginning to utilize accurate and sensitive diagnostic tests based on

NIST LabCAS: Data Driven Science Architecture and Resource

Ongoing
Biological data lie at the heart of innovation and artificial intelligence (AI) advances in the emerging biotechnology sector and serve as key strategic resources for achieving major breakthroughs in biomanufacturing, as summarized by the National Security Commission on Emerging Biotechnology's
NIST Foundry for Living Measurement Systems

NIST Living Measurement Systems Foundry

Ongoing
To enable the production of high-throughput, high-quality data that meets the rapidly evolving needs of current and future stakeholders, NIST has established an automation facility for the growth, manipulation, sample preparation, and measurement of engineered microbes. The core of the facility
Microbial Strain

NIST Microbial Strain Collection

Ongoing
Microorganisms of interest include but are not limited to those relevant to: biomanufacturing of advanced therapy products; rapid microbial testing; microbial therapeutics (e.g., live biotherapeutic products, probiotics, and fecal microbiota transplantations (FMTs)); infectious disease
NISTmAb RM8671 vial and 3D printed model

NIST Monoclonal Antibody Reference Material 8671

Ongoing
The NISTmAb material is a recombinant humanized IgG1κ expressed in murine suspension culture. It is an »150 kDa homodimer of two identical light chains and two identical heavy chains linked through both inter- and intra-chain disulfide bonds. The protein has low abundance post-translational
Medical Imaging Phantom

NIST/NIBIB Medical Imaging Phantom Lending Library

Ongoing
Phantoms are calibration objects that can be used to assess the accuracy, stability, and comparability of medical imaging systems. The NIST/ISMRM MRI system phantom can be used to assess scanner geometric distortion, image uniformity, signal to noise ratio (SNR), resolution, slice profile and

NIST Rapid Microbial Testing Methods Consortium

Ongoing
The safety and quality of advanced therapies, including cell therapy, gene therapy, and tissue engineered products, must be maintained prior to patient administration. The culture-based compendial methods currently used to assess product purity (specifically to ensure absence of microbial
Reference Measurement System for Urine Albumin

NIST Urine Albumin Standardization Program

Ongoing
Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of
Test tube illustrating NIST cell-free workshop topics

NIST Workshops on Cell-Free Expression Systems

Completed
NIST has co-hosted two cell-free workshops. NIST CELL-FREE (Comparable Engineered Living Lysates For Research Education and Entrepreneurship) Workshop (2019) The NIST CELL-FREE workshop took place in La Jolla, CA in February 2019, in collaboration with the J. Craig Venter Institute (JCVI). The
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