Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Projects/Programs

Displaying 101 - 125 of 214

Measuring Antimicrobial Resistance

Ongoing
Antibiotic resistance has been identified in the Nation’s Action Plan to improve the health and wellbeing of the American people. NIST scientists are leveraging a wide range of measurement capabilities to study microbial community dynamics with regard to antimicrobial resistance. Using a range of

Measuring Cell Viability in Scaffolds

Ongoing
Project Goals Primary Goal: Advance measurements of cell viability in manufactured tissues Establish working group of industry stakeholders to guide work Develop model scaffold-cell-assay system for measuring cell viability in scaffolds Validate measurement system by orthogonal test methods Assess

Method Assessment for Non-Targeted Analyses (MANTA) Program

Ongoing
Typical targeted analysis aims to detect and/or quantify a set of known chemical compounds using specific instrumental techniques (such as liquid chromatography with triple quadrupole mass spectrometry). In contrast, non-targeted analysis is an analytical technique that detects, identifies, and/or

Methods for Absolute Quantitation of Transcription

Ongoing
The ability to engineer novel, useful functions into microbial cells for manufacturing or therapeutic applications has accelerated rapidly over the last few decades. However, the measurements required to underpin predictive engineering of these systems are typically not comparable across different

Methods to Quantify Microbial Viability

Ongoing
Validating DNA-based methods to quantify viable bacteria ( S. Da Silva , G. Pinheiro) Microbial detection technologies based on nucleic acid measurements, such as polymerase chain reaction (PCR), are powerful detection tools that can provide relatively rapid results as compared to traditional

Metrologies for Protein Structure, Dynamics and Function

Ongoing
Based on its established expertise, infrastructure, and resources for structure/function studies of biological macromolecules, the program aims to impact advances in physics, chemistry, and engineering relevant to biological problems. NIST researchers also develop new technologies for application to

Metrology For Cell-Free Expression Systems

Ongoing
Cell-free expression systems are poised to advance the US bioeconomy and play a key role in ensuring US manufacturing resilience. NIST has several, on-going projects in its growing portfolio to promote reproducibility, new measurement methods, and best practices and standards in cell-free expression

Metrology for Nanomaterials in Medicine

Ongoing
Drug products that incorporate nanomaterials are defined by FDA as non-biological complex drugs (NBCDs). NBCDs are a class of medical products that cannot be defined nor fully identified as traditional small-molecule drugs. NBCDs consist of different components that form a complex hybrid structure

Metrology and Standards for Canine Olfactory Detection of Explosives

Completed
Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large

Micro- and Nanoelectromechanical Systems

Completed
MEMS/NEMS are enabling technologies that bring new functionalities with the potential to radically transform markets ranging from consumer products to national defense. The meteoric rise of the smartphone is an excellent example, in which MEMS accelerometers, gyroscopes, microphones, displays, and

Microbial Genomic Measurements

Completed
The RM 8375 is a stable and homogeneous material whose intended use is whole genome sequencing quality control and proficiency testing. The genomic DNA is intended to be analyzed in the same way as any other sample a laboratory would analyze extracted DNA, such as through the use of genome assembly

Microbial Metabolomics

Ongoing
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex

Microcryocooler for Terahertz Detectors

Ongoing
DARPA has been interested in the development of cooled detector systems (infrared and terahertz) that require less than 1 W of input power (battery operated) and have a total volume less than about 4 cm 3. Such systems could be used for detection of enemy missile launches (infrared), chemical

Microfluidic Synthesis of Nanoparticles

Ongoing
Liposomes have found many applications, including targeted drug delivery, immunoassay amplification, and medical imaging. For targeted drug delivery and medical imaging applications, the microfluidic-synthesis method could allow the synthesis of liposomes at the point of care, so that problems with

Molecular Innovation in Agriculture

Ongoing
Plant science and breeding aim to develop new plant phenotypes with desired qualities, increased production, disease resistance, and traits that reduce water usage. At the federal level, plant research is conducted by the USDA's Animal and Plant Health Inspection Service (APHIS) and Agricultural

Monoclonal Antibody Mass Spectral Libraries

Ongoing
Intended Impact Modern mass spectrometers used in the field of proteomics and glycomics are capable of profiling hundreds, and even thousands of molecules in a single experiment. Each of these compounds is isolated and fragmented to form a mass spectrum. Therefore, interpretation of these mass

Mouse Allelic Ladder

Ongoing
What is an allelic ladder? An allelic ladder is a mixture of highly characterized alleles (known size and sequence) that are generated using the same primers as the test samples and are used during capillary electrophoresis for accurate allele call determination. Why is an allelic ladder important

Mpox (MPXV) Synthetic DNA PCR Standards

Ongoing
A new material from NIST can aid in the evaluation and development of selected qPCR assays for the mpox virus. We are offering a unit free of charge in exchange for your feedback, which will help us improve and further develop the material. Questions? Contact MPXV-RGTM [at] nist.gov (MPXV-RGTM[at]nist[dot]gov) . NIST supports the

Multi-Organ Microphysiological Systems

Ongoing
We are developing tissue chips and multi-tissue microphysiological devices that support the culture of multiple tissues with physiologically relevant connections and streams of cell-culture medium. The goal in this project is to construct a device that realistically mimics human metabolism as a