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Office of the Director

Projects/Programs

Displaying 1026 - 1050 of 1598
NIST Foundry for Living Measurement Systems

NIST Living Measurement Systems Foundry

Ongoing
To enable the production of high-throughput, high-quality data that meets the rapidly evolving needs of current and future stakeholders, NIST has established an automation facility for the growth, manipulation, sample preparation, and measurement of engineered microbes. The core of the facility

NIST Materials Resource Registry

Ongoing
The MRR is a comprehensive inventory of high-level data collections, repositories, databases, tools, software, and services useful to materials research and design but located anywhere in the world. Its specialization for Materials Science is in the domain-specific metadata and vocabulary it can

NIST Materials-focused Empirical Potentials Repositories and Efforts

Ongoing
SOFT MATTER WebFF: Force-field repository for organic and soft materials Frederick R. Phelan Jr., 1 and Huai Sun 2 1Materials Science and Engineering Division, NIST, Gaithersburg, MD 20899 2Aeon Technology Inc. and School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Microbial Strain

NIST Microbial Strain Collection

Ongoing
Microorganisms of interest include but are not limited to those relevant to: biomanufacturing of advanced therapy products; rapid microbial testing; microbial therapeutics (e.g., live biotherapeutic products, probiotics, and fecal microbiota transplantations (FMTs)); infectious disease
mass-in-vacuum precision mass comparator

The NIST Mise en Pratique since the Redefinition of the Kilogram

Ongoing
Realization Since the redefinition of the kilogram, the NIST Mass and Force Group has been closely involved with the NIST-4 Kibble balance project and its realization of the electronic kilogram via the Kibble Principle. Traceability post-realization is maintained through what is referred to as the
NISTmAb RM8671 vial and 3D printed model

NIST Monoclonal Antibody Reference Material 8671

Ongoing
The NISTmAb material is a recombinant humanized IgG1κ expressed in murine suspension culture. It is an »150 kDa homodimer of two identical light chains and two identical heavy chains linked through both inter- and intra-chain disulfide bonds. The protein has low abundance post-translational
Medical Imaging Phantom

NIST/NIBIB Medical Imaging Phantom Lending Library

Ongoing
Phantoms are calibration objects that can be used to assess the accuracy, stability, and comparability of medical imaging systems. The NIST/ISMRM MRI system phantom can be used to assess scanner geometric distortion, image uniformity, signal to noise ratio (SNR), resolution, slice profile and
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NIST Ocean Carbon Measurements

Ongoing
NIST is committed to sustaining the quality of ocean carbon measurements by developing capabilities to provide certified reference materials for the ocean carbonate system measurements and by conducting research to understand fundamental elements of the ocean carbon thermodynamic system. NIST Ocean
group photo taken at NCWM 2023 Annual Meeting; Craig VanBuren, Don Onwiler, and Mahesh Albuquerque of NCWM, Laurie Locascio and Katrice Lippa of NIST, Gene Robertson of NCWM, David Sefcik

NIST OWM – NCWM: An Enduring Partnership

Ongoing
The National Conference on Weights and Measures (NCWM) was first held as the “First Annual Meeting of Sealers of Weights and Measures of the United States” in 1905 and as part of the National Bureau of Standards (NBS), which was the predecessor non-regulatory agency to the National Institute of
Map of the Hawaiian islands showing outlines and major cities of the islands.

NIST U.S. Pacific Islands Program

Completed
To help address environmental research and resource management in the Pacific Islands region, the 111th U.S. Congress directed NIST to "expand its capabilities and resources into the Pacific region through a Pacific Islands component of NIST" and included funding to "expand its biodiversity storage
NIST PS1

NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid)

Completed
With explicit SI linkage, the overall impact of this apical reference material is profound—this primary standard, as well as forthcoming members of its class, provides technology transfer of chemical purity realization to the commercial sector for characterization of many thousands of organic

NIST Rapid Microbial Testing Methods Consortium

Ongoing
The safety and quality of advanced therapies, including cell therapy, gene therapy, and tissue engineered products, must be maintained prior to patient administration. The culture-based compendial methods currently used to assess product purity (specifically to ensure absence of microbial

NIST/SEMATECH Engineering Statistics Handbook

Ongoing
Description: The project began with a request from SEMATECH, a consortium of major U.S. semiconductor manufacturers, to update the National Bureau of Standards (NBS) Handbook 91, Experimental Statistics. Handbook 91, written by Mary Natrella of the NBS Statistical Engineering Lab, was a best-selling
Photograph of the NIST Standard Reference Photometer showing the component modules consisting of optical bench with sample and reference tubes, ozone generator module with controls and tubing, and control module with numeric LED displays.

The NIST Standard Reference Photometer for Ozone Measurement Traceability

Ongoing
The concentration of ozone in the atmosphere continues to be an important global issue both scientifically and politically. Stratospheric ozone protects the Earth from harmful UV radiation, while tropospheric ozoneis a major health concern and contributes to global climate change as a greenhouse gas
Evolution of Flat-histogram Monte Carlo Simulation

NIST Standard Reference Simulation Website

Ongoing
Molecular simulations, in particular Monte Carlo Molecular Simulation and Molecular Dynamics Simulation, are methods for computing the properties of some kind of system, for which the intermolecular interactions are specified via mathematical relationships derived from statistical mechanics. Since

NIST Stars

Ongoing
Several current astrophysical research programs require SI traceable flux measurements (also called spectral irradiance) at accuracies higher than currently available. For example, exoplanet research requires improved host star absolute brightness knowledge to better determine habitability
Image of a fentanyl mass spectrum shown in a lab notebook

NIST and the SWGDRUG Mass Spectral Reference Library of Seized Drugs

Ongoing
Synthetic drugs such as fentanyl and its analogues are driving an unprecedented epidemic of overdose deaths in the United States. Clandestine labs create these new substances in part to evade law enforcement. This places a major burden on federal, state, and local law enforcement agencies to
Cannabis

NIST Tools for Cannabis Laboratory Quality Assurance

Ongoing
Since the 1970s, cannabis (marijuana and hemp) and its constituent, Δ 9-tetrahydrocannabinol or THC, have been classified as Schedule I controlled substances. Seized evidence is tested by forensic laboratories, which verify the identity of the plant through macro- and microscopic evaluation and the
Photograph of hundreds of gas cylinders in a gas storage facility.

NIST Traceable Reference Material Program for Gas Standards

Ongoing
The Gas Mixture SRM, NTRM, and EPA Protocol Programs provide a mechanism to produce needed calibration gas standards with a well-defined traceability. These mixtures are specified in the Code of Federal Regulations (CFR) to calibrate instruments to be used to monitor regulated emissions. The NTRM
Reference Measurement System for Urine Albumin

NIST Urine Albumin Standardization Program

Ongoing
Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of
Test tube illustrating NIST cell-free workshop topics

NIST Workshops on Cell-Free Expression Systems

Completed
NIST has co-hosted two cell-free workshops. NIST CELL-FREE (Comparable Engineered Living Lysates For Research Education and Entrepreneurship) Workshop (2019) The NIST CELL-FREE workshop took place in La Jolla, CA in February 2019, in collaboration with the J. Craig Venter Institute (JCVI). The
Box for NISTCHO in center, vial of NISTCHO to the right

NISTCHO

Ongoing
NISTCHO, a new mammalian cell line of interest to the biopharmaceutical and biomanufacturing communities, is now available from the National Institute of Standards and Technology. This Chinese hamster ovary (CHO) cell line has been engineered by MilliporeSigma to express a non-originator version of
Johnson Noise Thermometer system

Noise Thermometry

Completed
The project has also created a quantum-based electronic temperature standard that uses the ACJVS in conjunction with measurement of the Johnson noise -- random electrical noise caused by thermal agitation in a conductor -- in resistors at arbitrary temperatures. This Johnson noise thermometry system
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