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Displaying 401 - 425 of 1612

Oxidatively Induced DNA Damage and Its Repair

December 30, 2016
Author(s)
M Miral Dizdar
Endogenous and exogenous reactive species react with DNA in living organisms by numerous mechanisms and cause oxidatively induced DNA damage with multiple lesions. If not repaired, DNA lesions can cause genetic instability, leading to mutagenesis and cell

Summary of NIST/SIM Chemical Metrology Working Group Training Opportunity: Isotope Dilution-Mass Spectrometry Clinical Measurement Course

December 22, 2016
Author(s)
Jeanita Pritchett, Katrice A. Lippa, Mary Bedner, Carolyn Q. Burdette, Johanna Camara, Brian E. Lang, Michael A. Nelson, Lane C. Sander, Lorna T. Sniegoski
The one week NIST-SIM chemical metrology training opportunity was designed to provide SIM NMI/DI laboratory personnel with in-depth classroom and hands-on laboratory experience for the implementation of isotope dilution/mass spectrometry (ID/MS) methods in

Enhanced Sensitivity of Neil1-/- Mice to Chronic UVB Exposure

December 1, 2016
Author(s)
M Miral Dizdar, Marcus J. Calkins, Vladimir Vartanian, Guldal Kirkali, Amanda K. McCullough, R. S. Lloyd, Pawel Jaruga
DNA base damage induced by oxidative stress and reactive oxygen species (ROS) are thought to be central mediators of ultraviolet light (UV)-induced carcinogenesis and skin aging. However, increased steady-state levels of ROS-induced DNA base damage have

Alterations in eicosanoid composition during embryonic development in the chorioallantoic membrane of the American alligator (Alligator mississippiensis) and domestic chicken (Gallus gallus)

November 1, 2016
Author(s)
John Bowden, Theresa M. Cantu, Jacob Scott, Jimena B. Perez-Viscasillas, Kevin M. Huncik, Matthew P. Guillette, Louis J. Guillette Jr.
Eicosanoids are signaling lipids that regulate several physiological processes in the mammalian placenta, including the initiation of parturition. Though all amniotes construct similar extraembryonic membranes during development, the composition and

Development and Characterization of Reference Materials for Genetic Testing

November 1, 2016
Author(s)
Justin M. Zook, Marc L. Salit, Lisa V. Kalman, Mickey Williams, Vivekananda Datta, Jin-Yeong Han
Characterized reference materials (RM) are needed for test development and validation, quality control procedures and proficiency testing to assure the quality of clinical laboratory tests. In this article, we review the development and characterization of

Integrative and comparative reproductive biology: From alligators to xenobiotics

November 1, 2016
Author(s)
Ashley S. Boggs-Russell, John Bowden, Abby G. Wenzel, Satomi Kohno, Heather J. Hamlin, Lori Cruze, Krista A. McCoy, Alison M. Roark, Thea M. Edwards, Theresa M. Cantu, Jessica A. Cloy-McCoy, Nicole A. McNabb, Cameron E. Williams
Dr. Louis J. Guillette Jr. thought of himself as a reproductive biologist. However, his interest in reproductive biology transcended organ systems, life history stages, species, and environmental contexts. His integrative and collaborative nature led to

Caring: An Undiscovered Super "Ility" of Smart Healthcare

October 28, 2016
Author(s)
Nancy Laplante, Phillip Laplante, Jeff Voas
As new and exciting applications emerge using smart technologies, the Internet of Things, data analytics, and others for healthcare, a critical problem is emerging: the potential loss of "caring." The interplay of technology and caring has been discussed

Enhanced Sensitivity of Neil1-/- Mice to Chronic UVB Exposure

October 28, 2016
Author(s)
Pawel Jaruga, M Miral Dizdar, Marcus J. Calkins, Vladimir Vartanian, Amanda McCullough, R. S. Lloyd, Guldal Kirkali
Oxidative stress and oxidatively induced DNA base damage are central mediators of UV-induced carcinogenesis and skin aging. However, increased steady-state levels of oxidatively induced DNA base damage have not been reported after chronic UV exposure

FINE-TUNING ELECTRICAL FLOW RATE SENSING IN DEFORMABLE CHANNELS

October 9, 2016
Author(s)
Pengfei Niu, Brian J. Nablo, Kiran Bhadriraju, Darwin Reyes-Hernandez
Here we present conclusive proof that when using electrical impedance to measure volumetric flow rate in polydimethylsiloxane (PDMS) microchannels a considerable fraction of the change in impedance, due to change in flow rate, is caused by the variation in

Elevated urinary levels of 8-hydroxy-2’-deoxyguanosine, (5’R)- and (5’S)-8,5’-cyclo-2’- deoxyadenosines, and 8-iso-prostaglandin F2? as potential biomarkers of oxidative stress in patients with prediabetes

September 26, 2016
Author(s)
M Miral Dizdar, Melis Kant, Merve Akis, Mehmet Calan, Tugba Arkan, Firat Bayraktar, Huray Islekel
Prediabetes is the preclinical stage of type 2 diabetes mellitus with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress and that reactive oxygen species contribute to the production of insulin resistance, β-cell

A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance - The T 1 Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program

September 22, 2016
Author(s)
Gabriella Captur, Peter Gatehouse, Katy Keenan, Friso Heslinga, Ruediger Bruehl, Marcel Prothmann, Martin J. Graves, Richard J. Eames, Camilla Torlasco, Giulia Benedetti, Jacqueline Donovan, Bernd Ittermann, Redha Boubertakh, Andrew Bathgate, Celine Royet, Wenjie Pang, Reza Nezafat, Michael Salerno, Peter Kellman, James C. Moon
Background: T1 mapping and extracellular volume (ECV) have the potential to guide patient care and serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners and pulse sequences. To
Displaying 401 - 425 of 1612
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