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Application of Falling-Needle Rheometry to Highly Concentrated DNA Solutions.



Jessica L. Burger, Hideki Yamamoto, Takamasa Suzuki, Arno D. Laesecke


High concentration DNA solutions are common both in vitro and in vivo, and understanding the rheological properties is a critical area of bioscience. Our previous measurements on high concentration DNA solutions (2-6 mg/ml) interestingly provided evidence for a viscosity maximum with temperature in both the Ubbelohde capillary viscometer and rotating concentric cylinder viscometer which could be represented by a two-liquids model for solutions of double-and single-stranded DNA. In the work presented here we have expanded on our previous research and utilized a falling-needle rheometer in order to gain more insight into the nature of the previously observed viscosity maxima. We have shown that this viscosity increase is highly dependent on shear stress.


Calf thymus DNA, falling-needle rheometer, yield stress, melting temperature, and viscosity.


Burger, J. , Yamamoto, H. , Suzuki, T. and Laesecke, A. (2014), Application of Falling-Needle Rheometry to Highly Concentrated DNA Solutions., Biorheology, [online], (Accessed May 24, 2024)


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Created March 18, 2014, Updated November 10, 2018