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Certification of Total Arsenic in Blood and Urine Standard Reference Materials by Radiochemical Neutron Activation Analysis and Inductively Coupled Plasma Mass Spectrometry

Published

Author(s)

Rick L. Paul, William C. Davis, Karen E. Murphy, Colleen E. Bryan Sallee, Lee L. Yu, William F. Guthrie, Dennis D. Leber, Thomas W. Vetter

Abstract

A newly developed procedure for determination of arsenic by radiochemical neutron activation analysis was used to measure arsenic in SRM 955c Toxic Elements in Caprine Blood and SRM 2668 Toxic Elements in Frozen Human Urine for the purpose of providing mass concentration values for certification. Samples were freeze-dried prior to analysis followed by neutron irradiation for 3 h at 1x1014cm-2s-1. After sample dissolution in perchloric and nitric acids, arsenic was separated from the matrix by extraction into zinc diethyldithiocarbamate in chloroform, and 76As quantified by gamma-ray spectroscopy. RNAA results were combined with ICP-MS values from NIST and collaborating laboratories to provide certified values.
Citation
Journal of Radioanalytical and Nuclear Chemistry
Volume
299
Issue
3

Keywords

neutron activation analysis, radiochemistry, inductively coupled plasma mass spectrometry, standard reference materials

Citation

Paul, R. , Davis, W. , Murphy, K. , Bryan, C. , Yu, L. , Guthrie, W. , Leber, D. and Vetter, T. (2014), Certification of Total Arsenic in Blood and Urine Standard Reference Materials by Radiochemical Neutron Activation Analysis and Inductively Coupled Plasma Mass Spectrometry, Journal of Radioanalytical and Nuclear Chemistry, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=909821 (Accessed June 18, 2021)
Created March 1, 2014, Updated January 27, 2020