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Measuring Organelle Shape in 3D in Stem Cells Cultured on Nanofiber Scaffolds

Published

Author(s)

Carl G. Simon Jr., Peter Bajcsy, Wojtek J. Tutak, Jyotsnendu J. Giri

Abstract

Previous work has demonstrated that culture of osteoprogenitor cells on nanofiber scaffolds can potentiate osteogenic differentiation [1-4]. Culture of cells in nanofiber scaffolds causes changes to cell morphology, suggesting that morphological changes cause cell functional changes. Herein, it was hypothesized that nanofiber effects on cell morphology would influence their behavior by altering organelle structure and function. Primary human bone marrow stromal cells (hBMSCs) were cultured on nanofiber scaffolds and the 3D shape of their organelles was measured using confocal microscopy.
Proceedings Title
Society for Biomaterials 2014 Annual Meeting & Exposition
Volume
1
Issue
1
Conference Dates
April 16-19, 2014
Conference Location
Denver, CO

Keywords

stem cell, cell shape, nanofibers, biomaterials, tissue engineering

Citation

Simon, C. , Bajcsy, P. , Tutak, W. and Giri, J. (2014), Measuring Organelle Shape in 3D in Stem Cells Cultured on Nanofiber Scaffolds, Society for Biomaterials 2014 Annual Meeting & Exposition, Denver, CO (Accessed April 17, 2024)
Created April 19, 2014, Updated February 19, 2017