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Physics

Biological Physics

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Displaying 26 - 50 of 197

Nanopore sensing: a physical-chemical approach

September 1, 2021
Author(s)
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from

Origin and control of ionic hydration patterns in nanopores

June 18, 2021
Author(s)
Miraslau L. Barabash, William A. Gibby, Carlo Guardiani, Alexander Smolyanitsky, Dmitry G. Luchinsky, Peter V. McClintock
In order to permeate a nanopore, an ion must overcome a dehydration energy barrier caused by the redistribution of surrounding water molecules. The redistribution is inhomogeneous, anisotropic and strongly position-dependent, resulting in complex patterns

Field-induced dehydration and optimal ionic escape paths for C2N membranes

June 11, 2021
Author(s)
Miroslav Barabash, William Gibby, Dmitry Luchinsky, Binquan Luan, Alexander Smolyanitsky, Peter McClintock
Most analytic theories describing electrostatically driven ion transport through water-filled nanopores assume that the corresponding permeation barriers are bias-independent. While this assumption may hold for sufficiently wide pores under infinitely

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals

May 11, 2021
Author(s)
Aleksey Yevtodiyenko, Arkadiy Bazhin, Pavlo Khodakivskyi, Aurelien Godinat, Gyslain Budin, Marina Kunchulia, Giorgio Pietramaggiori, Sandra Scherer, Elena Goun, Sergey Polyakov, George P. Eppeldauer
Bioluminescent imaging (BLI) is one of the most powerful and widely used preclinical imaging modalities. However, the current technology relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited

Single-cell measurement of plasmid copy number and promoter activity

March 5, 2021
Author(s)
Bin Shao, Jayan Rammohan, Daniel Anderson, Nina Alperovich, David J. Ross, Christopher Voigt
We have developed a method to simultaneously count plasmid DNA, RNA transcripts, and protein expression in single living bacteria. From these data, the activity of a promoter in units of RNAP/s can be inferred. This work facilitates the reporting of

Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices

February 17, 2021
Author(s)
Ramya Vishnubhotla, Sarah Robinson, Jon R. Askim, Christopher B. Montgomery, Kristen L. Steffens, Herman O. Sintim, Stephen Semancik
Conformational changes of single-stranded DNA (ssDNA) play an important role in a DNA strand's ability to bind to target ligands. A variety of factors can influence conformation, including temperature, ionic strength, pH, buffer cation valency, strand

Spectropolarimetry of primitive phototrophs as global surface biosignatures

February 4, 2021
Author(s)
William Sparks, M. N. Parenteau, Robert E. Blankenship, Thomas Germer, C.H. L. Patty, Kimberly M. Bott, Charles M. Telesco, Victoria S. Meadows
Photosynthesis is an ancient metabolic process that began on the early Earth, offering plentiful energy to organisms that utilize it, to the extent that they can achieve global significance. The potential exists for similar processes to operate on

Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application

September 1, 2020
Author(s)
Jeeseong Hwang, Christopher S. Yung, Ruimin Chen, Yun He, Junhui Shi, Lihong Wang, Qifa Zhou
We report the development of an optically transparent high-frequency ultrasonic transducer using lithium niobate single-crystal and indium-tin-oxide electrodes with up to 90 % optical transmission in the visible to near infrared spectrum. The center
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