Biological physics

News and Updates

Sneezes, Rain Clouds and Ink Jets: NIST Improves the Ability of Optical Microscopes to Measure the Volume of Microdroplets

December 20, 2021

Sneezes, rain clouds, and ink jet printers: They all produce or contain liquid droplets so tiny it would take several billion of them to fill a liter bottle

Neutrons Help Measure Cell Membrane Viscosity — and Reveal Its Basis

August 12, 2021

We now have a clearer picture of the lightning-fast molecular dance occurring within the membrane that encloses each cell in our body, revealed in part by

Identifying Individual Molecules: NIST Study Suggests How to Build a Better ‘Nanopore’ Biosensor

April 27, 2021

Researchers have spent more than three decades developing and studying miniature biosensors that can identify single molecules. In five to 10 years, when such

Projects and Programs

Medical (Archive): Workshop for Radiobiology Dosimetry Standardization

Completed

A program for the development of dosimetry standards for radiobiology was launched through a highly successful workshop. The NIAID/NCI/NIST-sponsored workshop

Label-free imaging of cells and their extracellular matrix by SPR imaging

Ongoing

Metrology For Cell-Free Expression Systems

Ongoing

The Cellular Engineering Group works to provide measurement assurance for more reproducible and comparable cell-free expression systems.

MML researchers develop reference materials and methods for quantitative phase microscopy with off-the-shelf products

Measurement Assurance for Quantitative Cell Imaging by Optical Microscopy

Ongoing

Publications

Measuring Excess Heat Capabilities of Deoxyribonucleic Acid (DNA) Folding at the Single-Molecule LEvel

January 3, 2022

Author(s)

David Nicholson, Bin Jia, David Nesbitt

HDX-MS and MD simulations provide evidence for stabilization of the IgG1— FcγRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021

Author(s)

Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens

Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and

Modulation of a protein-folding landscape revealed by AFM-based force spectroscopy notwithstanding instrumental limitations

December 7, 2021

Author(s)

Devin T. Edwards, Marc-Andre LeBlanc, Thomas Perkins

Nanopore sensing: a physical-chemical approach

September 1, 2021

Author(s)

Joseph W. Robertson, Madhav Ghimire, Joseph Reiner

Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes

Software

NIST's Integrated Colony Enumerator (NICE)

January 4, 2021

Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size

Tools and Instruments

Beamline 10: Quantitative Hyperspectral Infrared Microscopy

The new beamline 10, currently under construction, is intended for applications that make use of the super-thermal brightness from SURF in the near- to mid