Nanopore sensing: a physical-chemical approach

Published

September 1, 2021

Author(s)

Joseph W. Robertson, Madhav Ghimire, Joseph Reiner

Abstract

Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from the Coulter counter and squid axon studies through the modern applications of these sensors including exquisite detection of small volume changes and molecular reactions at the single molecule (or reactant) scale. The review focuses on the chemistry of biological pores, and how that influences the physical chemistry of molecular detection.

Citation

Biochimica Et Biophysica ACTA-Biomembranes

Volume

1863

Issue

9

Pub Type

Journals

Download Paper

https://doi.org/10.1016/j.bbamem.2021.183644

Local Download

Keywords

nanopore sensor, ion channel, porin, DNA sequencing, peptide detection

Citation

Robertson, J. , Ghimire, M. and Reiner, J. (2021), Nanopore sensing: a physical-chemical approach, Biochimica Et Biophysica ACTA-Biomembranes, [online], https://doi.org/10.1016/j.bbamem.2021.183644, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=931550 (Accessed October 13, 2025)