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Nanotechnology

Nanobiotechnology

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Displaying 1 - 25 of 144

Evaluation of sources of variability in a nitric oxide screening assay for engineered nanomaterials

November 18, 2025
Author(s)
Tariq Fahmi, Robert Gutierrez, Ana Barrios, Tae Joon Cho, John Elliott, Sanghamitra Majumdar, Bryant Nelson, Aaron Johnston-Peck, Alessandro Tona, Anil Patri, Elijah Petersen
Assays to detect potential biocompatibility issues can play a key role in supporting the development of new technologies such as medical products containing engineered nanomaterials (ENMs). In this paper, we describe an evaluation of sources of uncertainty

The structure and morphology of single-component oligomeric RNA delivery vectors derived from amphiphilic Charge-Altering Releasable Transporters

November 6, 2025
Author(s)
Paul Hurst, Yuan Jia, Summer Ramsay-Burrough, Rebecca McClellan, Joshua Arens, Samuel Khasnavis, Trevor del Castillo, Mahmoud AbdElwakil, Michael Lueckheide, Vivek Prabhu, Robert Waymouth
Recent advances in nucleic acid delivery have been inspired by efforts to mimic the function of natural viruses through the development of self-assemblies capable of transporting oligonucleotides across the cell and endosomal membranes. Lipid nanoparticles

The Need for Standardization of Extracellular Vesicle Characterization Methods

October 1, 2025
Author(s)
Bryant Nelson, Wyatt Vreeland
Extracellular vesicles (EVs) are secreted from all living organisms. The application of EVs in therapeutics, clinical diagnostics and drug delivery is expanding rapidly and the EV field is set to capitalize on this expansion through the development of next

Entropic modulation of divalent cation transport

September 22, 2025
Author(s)
Yechan Noh, Demian Riccardi, Alexander Smolyanitsky
Aqueous cations permeate subnanoscale pores by crossing free energy barriers dominated by competing enthalpic contributions from transiently decreased ion-solvent and increased ion-pore electrostatic interactions. This commonly accepted view is rooted in

Variable Gain DNA Nanostructure Charge Amplifiers for Biosensing

December 7, 2024
Author(s)
Jacob Majikes, Seulki Cho, Thomas Cleveland, James Liddle, Arvind Balijepalli
Electronic measurements of engineered nanostructures comprised solely of DNA (DNA nanostructures) enable new signal conditioning modalities in biosensing. Here, we demonstrate how these DNA nanostructures alter their conformation upon binding a nucleic

Toward an International Standardisation Roadmap for Nanomedicine

June 12, 2024
Author(s)
Bryant C. Nelson, Gerrit Borchard, Luigi Calzolai, Fanny Caputo, Georges Favres, Fisicaro Fisicaro, Emeric Frejafon, Nazende Gunday-Tureli, Denis Koltsov, Caterina Minelli, Francois-Xavier Ouf, Jeremie Parot, Adriele Prina Mello, Shan Zou
The French National Measurement Institute (LNE) has initiated a series of events to identify priorities for test methods and their harmonisation that directly address regulatory needs in Nanomedicine. The workshop entitled "The International

Heart-on-a-Chip Systems: Disease Modeling and Drug Screening Applications

February 14, 2024
Author(s)
Derrick Butler, Darwin Reyes-Hernandez
Cardiovascular disease (CVD) is the leading cause of death worldwide, casting a substantial economic footprint and burdening the global healthcare system. Historically, pre-clinical CVD modeling and therapeutic screening has been performed using animal

Stability-Enhanced Cisplatin Gold Nanoparticles as Therapeutic Anticancer Agents

December 22, 2023
Author(s)
Tae Joon Cho, Vytas Reipa, John Pettibone, Justin Gorham, Allesandro Tona, Aaron Johnston-Peck, Bryant C. Nelson, Vincent Hackley
Using dendron chemistry, we developed stability-enhanced carboxylate surfacemodified (negatively charged dendron) AuNPs (Au-NCD). Since the carboxylate surface of Au- NCD is optimal for complexation with cisplatin (Pt) moieties, we further synthesized Pt

Federal perspective on critical research issues in nanoEHS

August 31, 2023
Author(s)
Janet Carter, Sri Nadadur, Rhema Bjorkland, William Boyes, Chuck Geraci, Vincent A. Hackley, John Howard, Alan Kennedy, Igor Linkov, Joanna Matheson, Holly Mortensen, Custudio Muinga, Elijah Petersen, Nora Savage, Stacey Standridge, Trey Thomas, Benjamin Trump
This article discusses critical issues and opportunities going forward in nanotechnology environmental, health, and safety (nanoEHS) research from the perspective of Federal Government agency participants in the U.S. National Nanotechnology Initiative (NNI

mDTEB, a new fluorescent label for carbohydrate nano-material in vivo studies

May 27, 2023
Author(s)
Jeremiah Woodcock, Douglas M. Fox, Ilabahen A. Patel, Joy Dunkers, Stephan J. Stranick, Jeffrey W. Gilman
Typical studies of gastral toxicity are conducted using radio labeling. This tends to be quite expensive and difficult owing to the required protocols for working with these materials and the expense of the chemical reagents. A possible alternative is

Polyethyleneimine/polyethylene glycol-conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: Testing in frog embryo teratogenesis assay-Xenopus and mammalian tissue culture system

March 15, 2023
Author(s)
Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C. Nelson, David A. LaVan, Vincent A. Hackley, Tae Joon Cho
Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National

Orthogonal and complementary measurements of properties of drug products containing nanomaterials

January 6, 2023
Author(s)
Bryant C. Nelson, Elijah Petersen, Carl Simon Jr., Sven-Even Borgos, Luigi Calzolai, Jeremie Parot, Matthias Roesslein, Fanny Caputo, Xiaoming Xu
Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical quality attributes (CQAs). The task becomes particularly challenging for drug products and

Current Nanomaterials Toxicity Testing Needs and Use of New Approach Methodologies Among Selected U.S. Federal Agencies

April 11, 2022
Author(s)
Elijah Petersen, Patricia Ceger, Jayme Coyle, David Allen, Raymond Derk, Natalia Garcia-Reyero, John Gordon, Nicole Kleinstreuer, Joanna Matheson, Danielle McShan, Bryant Nelson, Anil Patri, Liying Rojanasakul, Abhilash Sasidharan, Louis Scarano, Xiaoqing Chan
Engineered nanomaterials (ENMs) come in a wide array of shapes, sizes, surface coatings, and compositions, and often possess novel or enhanced properties compared to larger sized particles of the same elemental composition. To ensure the safe

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021
Author(s)
Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch
Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising in vitro method to supplement or ultimately
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