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Nanotechnology

Nanobiotechnology

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Displaying 26 - 50 of 146

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021
Author(s)
Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch
Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising in vitro method to supplement or ultimately

Critical considerations for the design of multi-organ microphysiological systems (MPS)

September 9, 2021
Author(s)
Mridu Malik, Yang Yang, Parinaz Fathi, Gretchen Mahler, Mandy Esch
The process of identifying new drugs and getting them approved for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases. The reliability of data

Nanopore sensing: a physical-chemical approach

September 1, 2021
Author(s)
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from

Near-Infrared Emitting Dual-Stimuli-Responsive Carbon Dots from Endogenous Bile Pigments

August 12, 2021
Author(s)
Parinaz Fathi, Parikshit Moitra, Madeleine M. McDonald, Mandy Esch, Dipanjan Pan
Careful selection of carbon dot precursors and surface modification techniques has allowed for the development of carbon dots with strong near-infrared fluorescence emission. However, the rational selection of tetrapyrrolic carbon dot precursors to obtain

Ionization and Structural Properties of mRNA Lipid Nanoparticles that Influence Expression in Intramuscular and Intravascular Administration

August 11, 2021
Author(s)
Manuel Carrasco, Suman Alishetty, Mohamad-Gabriel Alameh, Hooda Said, Lacey Wright, Mikell Paige, Ousamah Soliman, Drew Weissman, Thomas Cleveland, Alexander Grishaev, Michael Buschmann
Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a method that can predict the LNP pKa from

Dynamic light scattering distributions by any means

May 21, 2021
Author(s)
Natalia Farkas, John A. Kramar
Dynamic light scattering (DLS) is an essential technique for nanoparticle size analysis and has been employed extensively for decades, but despite its long history and popularity, the choice of weighting and mean of the size distribution often appears to

Combining secondary ion mass spectrometry image depth profiling and single particle inductively coupled plasma mass spectrometry to investigate the uptake and biodistribution of gold nanoparticles in Caenorhabditis elegans

May 20, 2021
Author(s)
Monique Johnson, Joe Bennett, Antonio Montoro Bustos, Shannon Hanna, Andrei Kolmakov, Nicholas Sharp, Elijah Petersen, Christopher Sims, Bryant Nelson, Patricia Lapasset
Analytical techniques capable of determining the spatial distribution and quantity (mass and/or particle number) of engineered nanomaterials in organisms are essential for characterizing nano-bio interactions and for nanomaterial risk assessments. Here, we

Failure mechanisms in DNA self-assembly: Barriers to single fold yield

February 23, 2021
Author(s)
Jacob Majikes, Paul Patrone, Anthony J. Kearsley, Michael P. Zwolak, James Liddle
Understanding the folding process of DNA origami is a critical steppingstone to the broader implementation of nucleic acid nanofabrication technology but is notably non-trivial. Origami are formed by several hundred cooperative hybridization events – folds

Conformational Changes of Immobilized Polythymine due to External Stressors Studied with Temperature-Controlled Electrochemical Microdevices

February 17, 2021
Author(s)
Ramya Vishnubhotla, Sarah Robinson, Jon R. Askim, Christopher B. Montgomery, Kristen L. Steffens, Herman O. Sintim, Stephen Semancik
Conformational changes of single-stranded DNA (ssDNA) play an important role in a DNA strand's ability to bind to target ligands. A variety of factors can influence conformation, including temperature, ionic strength, pH, buffer cation valency, strand

DNA Origami Design: A How-To Tutorial

January 8, 2021
Author(s)
Jacob Majikes, James Alexander Liddle
While the design and assembly of DNA origami are straightforward, its relative novelty as a nanofabrication technique means that the tools and methods for designing new structures have not been codified as well as they have for more mature technologies

Revealing thermodynamics of DNA origami folding via affine transformations

June 4, 2020
Author(s)
Jacob M. Majikes, Paul N. Patrone, Daniel R. Schiffels, Michael P. Zwolak, Anthony J. Kearsley, Samuel P. Forry, James A. Liddle
Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and construction of molecularly precise objects for a myriad of applications. However, limitations in imaging, and other characterization approaches, make a quantitative

Precise pitch-scaling of ultra-scaled carbon nanotube arrays within 3D DNA nano-trenches

May 22, 2020
Author(s)
Jason K. Streit, Jeffrey Fagan, Ming Zheng, Wei Sun, Peng Yin, Jie Shen, Zhao Zhao, Hareem Maune
Precise assembly of carbon nanotubes (CNTs) into densely-aligned uniformly parallel arrays has been the missing link towards the emerging ultra-scaled post-Si technology nodes specified in the International Technology Roadmap for Semiconductors (ITRS)

Infrared and Raman chemical imaging and spectroscopy at the nanoscale

May 19, 2020
Author(s)
Dmitry Kurouski, Alexandre Dazzi, Renato Zenobi, Andrea Centrone
The advent of nanotechnology, and the need to understand the chemical composition at the nanoscale, has stimulated the convergence of IR and Raman spectroscopy with scanning probe methods, resulting in new nanospectroscopy paradigms. Here we review two of

Sizing up the Next Generation of Nanomedicines

December 11, 2019
Author(s)
Jeffrey D. Clogston, Vincent A. Hackley, Adriele Prina-Mello, Sanyogitta Puri, Silvia Sonzini, Patrick Lim Soo
During the past two decades the field of nanomedicines has experienced significant progress. To date, over sixty nanoparticle (NP) formulations have been approved in the US and EU while many others are in clinical or preclinical development, indicating a

Topology, Landscapes, and Biomolecular Energy Transport

October 11, 2019
Author(s)
Justin E. Elenewski, Kirill Velizhanin, Michael P. Zwolak
While ubiquitous, energy redistribution remains a poorly understood facet of the nonequilibrium thermodynamics of biomolecules. At the molecular level, finite-size effects, pronounced nonlinearities, and ballistic processes conspire to produce behavior

Quantum Capacitance-Limited MoS2 Biosensors Enable Remote Label-Free Enzyme Measurements

August 7, 2019
Author(s)
Son T. Le, Nicholas B. Guros, Robert C. Bruce, Antonio Cardone, Niranjana D. Amin, Siyuan Zhang, Jeffery B. Klauda, Harish C. Pant, Curt A. Richter, Arvind Balijepalli
We have demonstrated atomically thin, quantum capacitance-limited, field-effect transistors (FETs) that enable the detection of pH changes with 75-fold higher sensitivity (4.4 V/pH) over the Nernst value of 59 mV/pH at room temperature when used as a
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