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Stability-Enhanced Cisplatin Gold Nanoparticles as Therapeutic Anticancer Agents
Published
Author(s)
Tae Joon Cho, Vytas Reipa, John Pettibone, Justin Gorham, Allesandro Tona, Aaron Johnston-Peck, Bryant C. Nelson, Vincent Hackley
Abstract
Using dendron chemistry, we developed stability-enhanced carboxylate surfacemodified (negatively charged dendron) AuNPs (Au-NCD). Since the carboxylate surface of Au- NCD is optimal for complexation with cisplatin (Pt) moieties, we further synthesized Pt-loaded Au-NCD (Au-NCD/Pt) to serve as potential therapeutic anticancer agents. The size distribution, zeta potential, and surface plasmon resonance of both Au-NCDs and Au-NCD/Pt were characterized via dynamic light scattering, scanning transmission electron microscopy, and ultraviolet−visible spectrophotometry. Surface chemistry, Pt uptake, and Pt release were evaluated using inductively coupled plasma-mass spectrometry and X-ray photoelectron spectroscopy. Colloidal stability in physiological media over a wide pH range (1−13) and shelf-life stability (up to 6 months) were also assessed. Finally, the cytotoxicity of both Au-NCD and Au-NCD/Pt to Chinese hamster ovary cells (CHO K1; as a normal cell line) and to human lung epithelial cells (A549; as a cancer cell line) was evaluated. The results of these physicochemical and functional cytotoxicity studies with Au-NCD/Pt demonstrated that the particles exhibited superlative colloidal stability, cisplatin uptake, and in vitro anticancer activity despite low amounts of Pt release from the conjugate.
Cho, T.
, Reipa, V.
, Pettibone, J.
, Gorham, J.
, Tona, A.
, Johnston-Peck, A.
, Nelson, B.
and Hackley, V.
(2023),
Stability-Enhanced Cisplatin Gold Nanoparticles as Therapeutic Anticancer Agents, ACS Applied Nano Materials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=956563
(Accessed October 9, 2025)