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Health

Clinical diagnostics

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Displaying 76 - 100 of 158

An updated protocol based on CLSI document C37 for preparation of off-the-clot serum from individual units for use alone or to prepare commutable pooled serum reference materials

October 30, 2019
Author(s)
Johanna Camara, Uliana Danilenko, Hubert W. Vesper, Gary L. Myers, Patric A. Clapshaw, W. Greg Miller
Manufacturers of in-vitro diagnostic medical devices, clinical laboratories, research laboratories and calibration laboratories require commutable reference materials that can be used in the calibration hierarchies of medical laboratory measurement

Enhancing the Accuracy of Measurement of Small Molecule Organic Biomarkers

October 30, 2019
Author(s)
Tang Lin Teo, Katrice Lippa, Lindsey Mackay, Sharon Yong, Qinde Liu, Johanna Camara, Vincent Delatour, Tong Kooi Lee, Beatrice Lalere, Gavin O'Connor, Andr? Henrion, Megumi Kato, Jane L. Fernandes, Masahiko Numata, Ha-Jeong Kwon, Ji-Seon Jeong, Bei Xu, Jintana Nammoommoy, Dewei Song, Wagner Wollinger
Over two decades, the Organic Analysis Working Group (OAWG) of the Consultative Committee for Amount of Substance (CCQM) has organised a number of comparisons for clinically relevant small molecule organic biomarkers. These comparisons are hinged upon the

Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids: Building a Spectral Library of Recurrent Spectra for Urine Analysis

August 18, 2019
Author(s)
Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri Mirokhin, Stephen E. Stein
A large fraction of ions observed in electrospray liquid chromatography–mass spectrometry (LC–ESI-MS) experiments of biological samples remain unidentified. One of the main reasons for this is that spectral libraries of pure compounds fail to account for

Biodegradable biliverdin nanoparticles for efficient photoacoustic imaging

June 27, 2019
Author(s)
Parinaz Fathi, Knox J. Hailay, Dinabandhu Sar, Indu Tripathi, Ostadhossein Fatemeh, Misra K. Santosh, Mandy Esch, Jefferson Chan, Dipanjan Pan
Here we report the synthesis of nanoparticles composed of Biliverdin cross-linked with a bifunctional amine functionalized linker. The nanoparticles display high absorbance at 365 nm and 680 nm, fluorescence when excited at 365 nm, and photoacoustic

High-coverage, long-read sequencing of Chinese trio reference samples

June 14, 2019
Author(s)
Justin M. Zook, Nathanael D. Olson, Marc L. Salit, Aaron Wenger, Chunlin Xiao, Robert Sebra
Genome In a Bottle (GIAB) is a consortium hosted by the National Institute of Standards and Technology whose primary objective is the development and characterization of human genomic reference materials. The consortium includes representatives from

An open resource for accurately benchmarking small variant and reference calls

April 1, 2019
Author(s)
Justin M. Zook, Jennifer H. McDaniel, Marc L. Salit, Nathanael D. Olson, Justin M. Wagner
Benchmark small variant calls are required for developing, optimizing and assessing the performance of sequencing and bioinformatics methods. Here, as part of the Genome in a Bottle (GIAB) Consortium, we apply a reproducible, cloud-based pipeline to

CrowdVariant: a crowdsourcing approach to curate copy number variants

January 6, 2019
Author(s)
Justin M. Zook, Marc L. Salit, Peyton Greenside, Ryan Poplin, Mark DePristo, Madeleine Cule
Copy number variants (CNVs) are an important type of genetic variation and play a causal role in many diseases. However, they are also notoriously difficult to identify accurately from next-generation sequencing (NGS) data. For larger CNVs, genotyping

Aflatoxin-guanine DNA Adducts and Oxidatively-induced DNA Damage in Aflatoxin-treated Mice in vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope-dilution

December 11, 2018
Author(s)
Erdem Coskun, Pawel Jaruga, Vladimir Vartanian, Onur Erdem, Patricia Egner, John D. Groopman, R. S. Lloyd, Miral M. Dizdar
Dietary exposure to aflatoxin (AFB1) is a significant reason for the incidence of hepatocellular carcinomas globally. AFB1-exposure leads to the formation of AFB1-N7-guanine (AFB1-N7-Gua) and two diastereomers of 8,9-dihydro-8-(2,6-diamino-4-oxo-3,4

The integration of emerging omics approaches to advance precision medicine: How can regulatory science help?

December 6, 2018
Author(s)
Mark S. Lowenthal, Christina M. Jones, Joan Adamo, Robert Bienvenu, Owen Fields, Soma Ghosh, Michael Liebman, Robert Schuck, Scott Steele
Building on the recent advances in next-generation sequencing, the integration of genomics, proteomics, metabolomics, and other approaches hold tremendous promise for precision medicine. The approval and adoption of these rapidly advancing technologies and

Certification of Standard Reference Material 2365 BK Virus DNA Quantitative Standard

August 29, 2018
Author(s)
Megan H. Cleveland, Natalia Farkas, Kevin M. Kiesler, Blaza Toman, Peter M. Vallone
Standard Reference Material (SRM) 2365 is intended for use in the value assignment of BK virus deoxyribonucleic acid (DNA) to BK DNA controls and standards. A unit of SRM 2365 consists of a well characterized, linearized plasmid, containing BK virus DNA

Conference Report: Representing Ethnic Diversity for Precision Medicine

August 23, 2018
Author(s)
Justin M. Zook, Luke Hickey, Benedict Paten, Robert Sebra, Valerie Schneider
There is a pressing need to better represent ethnic diversity with genomic resources — and to do so in a way that maximizes utility for people working with the Genome Reference Consortium’s human reference genome. That was the theme of a panel discussion

NIST Micronutrients Measurement Quality Assurance Program: Spring and Fall 1987 Comparability Studies-Results for Round Robins IX and XI Fat-Soluble Vitamins and Carotenoids in Human Serum

May 21, 2018
Author(s)
Jeanice M. Brown Thomas, David L. Duewer, Margaret C. Kline, Willie May, Emil Schonberger
From 1984 to 2017, the National Institute of Standards and Technology coordinated the Micronutrients Measurement Quality Assurance Program (MMQAP) for laboratories that measure fat- soluble vitamins and carotenoids in human serum and plasma. This report

State-of-the-art and trends for the SI traceable value assignment of the purity of peptides using the model compound angiotensin I

March 27, 2018
Author(s)
Ralf D. Josephs, Norbert Stoppacher, Adeline Daireaux, Tiphaine Choteau, Katrice Lippa, Karen W. Phinney, Steven Westwood, Robert Wielgosz
Accurate diagnosis, monitoring and treatment are cornerstones of a healthcare system and require reliable measurements. The traceability of measurement results to stated references, and the development of Reference Measurement Systems (RMS), provide

Electrochemical Detection of Acetaminophen with Silicon Nanowires

February 8, 2018
Author(s)
Raja Ram Pandey, Hussain S. Alshahrani, Sergiy Krylyuk, Elissa Williams, Albert Davydov, Charles C. Chusuei
Acetaminophen (APAP) is an antipyretic, analgesic agent. Overdose during medical treatment poses a risk for liver failure. Hence, it is important to develop methods to monitor APAP in the body to avoid APAP toxicity. Here, we report an efficient and

Recommendations for assessing commutability part 1: general experimental design

January 18, 2018
Author(s)
Johanna Camara, W. Greg Miller, Schimmel Heinz, Neil Greenberg, Chris Burns, Vincent Delatour, Mauro Panteghini, Hubert W. Vesper, Robert Rej, Ferruccio Ceriotti, Gerhard Schumann, Jeffrey R. Budd, Weykamp Cas, Goran Nilsson, Finlay MacKenzie, Thomas Keller
Commutability is a property of a reference material that relates to the closeness of agreement between results for a reference material and results for clinical samples when measured by two or more measurement procedures. Commutability of reference

Recommendations for assessing commutability part 2: based on the difference in bias between a reference material and clinical samples

January 18, 2018
Author(s)
Johanna Camara, Goran Nilsson, Jeffrey R. Budd, Neil Greenberg, Vincent Delatour, Gerhard Schumann, Robert Rej, Mauro Panteghini, Ferruccio Ceriotti, Schimmel Heinz, Weykamp Cas, Thomas Keller, Chris Burns, Finlay MacKenzie, W. Greg Miller
A process is described to assess the commutability of a reference material intended for use as a calibrator, trueness control or external quality assessment sample based on the difference in bias between a reference material and clinical samples measured
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