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Enhancing the Accuracy of Measurement of Small Molecule Organic Biomarkers



Tang Lin Teo, Katrice Lippa, Lindsey Mackay, Sharon Yong, Qinde Liu, Johanna Camara, Vincent Delatour, Tong Kooi Lee, Beatrice Lalere, Gavin O'Connor, Andr? Henrion, Megumi Kato, Jane L. Fernandes, Masahiko Numata, Ha-Jeong Kwon, Ji-Seon Jeong, Bei Xu, Jintana Nammoommoy, Dewei Song, Wagner Wollinger


Over two decades, the Organic Analysis Working Group (OAWG) of the Consultative Committee for Amount of Substance (CCQM) has organised a number of comparisons for clinically relevant small molecule organic biomarkers. These comparisons are hinged upon the key component of metrological traceability that make up sound measurement science. Metrology institutes within the OAWG, having demonstrate the equivalence of their capabilities in the field, provide certified reference materials as well as other dedicated value-assignment services to the clinical chemistry industry. The aim of the OAWG community is to be part of the coordinated international movement towards accuracy and comparability of clinical measurements that will in turn minimize the wastage of repeat testing and unnecessary therapy to create a sustainable healthcare industry. Keywords:


biomarker, clinical measurements, clinical tests, metrological traceability, certified reference materials (CRMs), pilot and key comparisons, commutability, External Quality Assessment (EQA)


Teo, T. , Lippa, K. , Mackay, L. , Yong, S. , Liu, Q. , Camara, J. , Delatour, V. , Lee, T. , Lalere, B. , O'Connor, G. , Henrion, A. , Kato, M. , Fernandes, J. , Numata, M. , Kwon, H. , Jeong, J. , Xu, B. , Nammoommoy, J. , Song, D. and Wollinger, W. (2019), Enhancing the Accuracy of Measurement of Small Molecule Organic Biomarkers, Metrologia, [online], (Accessed April 23, 2024)
Created October 29, 2019, Updated October 12, 2021