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Electrochemical Detection of Acetaminophen with Silicon Nanowires



Raja Ram Pandey, Hussain S. Alshahrani, Sergiy Krylyuk, Elissa Williams, Albert Davydov, Charles C. Chusuei


Acetaminophen (APAP) is an antipyretic, analgesic agent. Overdose during medical treatment poses a risk for liver failure. Hence, it is important to develop methods to monitor APAP in the body to avoid APAP toxicity. Here, we report an efficient and selective electrochemical APAP sensor based on glassy carbon electrodes (GCE) modified with silicon nanowires (SiNWs). Electrocatalytic activity of the SiNW/GCE sensors was monitored under various pH conditions and concentrations of APAP using cyclic voltammetry (CV) and chronoamperometry (CA). CV of the SiNWs at 0.5 mM to 13 mM APAP concentrations was used to determine the oxidation and reduction potential of APAP. The selective detection of APAP was then demonstrated using CA at +0.568 V, APAP's determined oxidation potential using CV, in the 0.01 mM to 3 mM concentration range. The SiNW sensor has the ability to detect APAP well within the detection limits for APAP toxicity, showing promise as a practical biosensor.


cyclic voltammetry, chronoamperometry, silicon nanowires, acetaminophen, electrochemical sensor


Pandey, R. , Alshahrani, H. , Krylyuk, S. , Williams, E. , Davydov, A. and Chusuei, C. (2018), Electrochemical Detection of Acetaminophen with Silicon Nanowires, Electroanalysis (Accessed April 14, 2024)
Created February 7, 2018, Updated October 12, 2021