Clinical diagnostics

News and Updates

New DNA Biosensor Could Unlock Powerful, Low-Cost Clinical Diagnostics

January 24, 2023

The biosensor, developed by researchers at NIST, Brown University and the French research institute CEA-Leti, identifies biomarkers by measuring how binding

Wi-Fi Could Help Identify When You’re Struggling to Breathe

December 20, 2022

NIST and its FDA collaborators advanced a technique to use Wi-Fi to sense when someone’s breathing pattern changes, indicating they’re in trouble.

A gloved hand is holding up a small plastic vial labeled "RGTM plasmid."

NIST Develops Genetic Material for Validating Mpox Tests

July 27, 2022

NIST is making the new material freely available to testing laboratories and diagnostic test manufacturers worldwide.

Projects and Programs

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

A new collaboration between NIST's Human Genomics Team, Mass Spectrometry Data Center, and Information Technology Laboratory to use and develop artificial

Genome in a Bottle

Ongoing

Consortium hosted by NIST dedicated to authoritative characterization of benchmark human genomes. Sign up for General GIAB and Analysis Team email lists. Public

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Ongoing

Metagenomic Next Generation Sequencing (mNGS) promises to revolutionize infectious disease diagnostics. However, the analytical performance of this technology

Standards for Metagenomics

Ongoing

Metagenomics, or identifying the organisms present in a sample through DNA-based analysis, is a revolutionary technology made possible through advances in

Publications

Certification of Standard Reference Material® 917d D Glucose (Dextrose)

March 1, 2023

Author(s)

Michael Nelson, Brian Lang, Blaza Toman, Jerome Mulloor

Standard Reference Material (SRM) 917d D Glucose (Dextrose) is certified as a chemical substance of known high purity. It is intended for use in calibrating

Health Assessment Measurements Quality Assurance Program: Exercise 7 Final Report

December 5, 2022

Author(s)

Chuck Barber, Carolyn Burdette, Hugh Hayes, Monique Johnson, Shaun Kotoski, Jacolin Murray, Melissa M. Phillips, Kate Rimmer, Andrea Yarberry, Laura J. Wood

The Health Assessment Measurements Quality Assurance Program (HAMQAP) was launched in collaboration with the National Institutes of Health (NIH) Office of

Benchmarking challenging small variants with linked and long reads

May 11, 2022

Author(s)

Justin Wagner, Nathanael David Olson, Lindsay Harris, Marc L. Salit, Fritz Sedlazeck, Chunlin Xiao, Justin Zook

Genome in a Bottle benchmarks are widely used to help validate clinical sequencing pipelines and develop variant calling and sequencing methods. Here we use

Conformance of a 3T Radiotherapy MRI Scanner to the QIBA Diffusion Profile

April 1, 2022

Author(s)

Madeline Carr, Katy Keenan, Robba Rai, Peter Metcalfe, Amy Walker, Lois Holloway

Software

NIST's Integrated Colony Enumerator (NICE)

January 4, 2021

Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size

Curated Archive for COVID-19 Research Challenge Dataset (cord19-cdcs-nist)

This GitHub repository contains a downloadable snapshot of National Institute of Standards and Technology's COVID-19 Data Repository, curated from the COVID-19