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Comparative Analysis of 1D PROFILE and 2D 1H,13C Methyl NMR Approaches for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

April 8, 2020

Author(s)

Wade Elliott, Houman Ghasriani, Mats Wikstrom, John Giddens, Yves Aubin, Frank Delaglio, John Marino, Luke Arbogast

Mass Spectral Library of Acylcarnitines Derived from Human Urine

April 8, 2020

Author(s)

Xinjian Yan, Sanford Markey, Ramesh Marupaka, Qian Dong, Brian T. Cooper, Yuri Mirokhin, William E. Wallace, Stephen Stein

We describe the creation of a mass spectral library of acylcarnitines and conjugated acylcarnitines from the LC–MS/MS analysis of six NIST urine reference materials. To recognize acylcarnitines, we conducted in-depth analyses of fragmentation patterns of

Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences

April 6, 2020

Author(s)

John E. Schiel, Coffman Jon, Bruno Marques, Griesbach Jan, Ambrose Williams, Gisela Ferreira, Rushd Khalaf, David Roush, Charles Haynes

Biopharmaceutical product and process development does not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition was

Certification of Standard Reference Material(R) 2859 and Standard Reference Material(R) 2861 Restricted Elements in Polyvinyl Chloride

April 1, 2020

Author(s)

John R. Sieber, John L. Molloy, Nathanael A. Heckert

The National Institute of Standards and Technology has issued its first Standard Reference Materials for elemental analysis of polyvinyl chloride. The custom designed PVC blends contain elements regulated in consumer products by the United States, the

NIST 2019 Interlaboratory Study to Determine Starch Content in Corn Grain Biomass Intermediates

March 26, 2020

Author(s)

Jacolin A. Murray

The National Institute of Standards and Technology is currently developing reference materials (RMs) to support the corn-to-ethanol industry. Two candidate RMs consisting of dried corn biomass intermediates before and after conversion (fermentation) were

Mass Spectrometry Advances and Perspectives for the Characterization of Emerging Adoptive Cell Therapies

March 19, 2020

Author(s)

Camille O. Lombard-Banek, John E. Schiel

Adoptive cell therapy is an emerging anti-cancer modality, whereby the patients own immune cells are engineered to express T-cell receptor (TCR) or chimeric antigen receptor (CAR). CAR-T cell therapies have advanced the furthest, with recent approvals of

How to Use and How Not to Use Certified Reference Materials in Industrial Chemical Metrology Laboratories

March 17, 2020

Author(s)

John R. Sieber

Working with industry labs quickly introduces one to activities of standard development organizations, who publish test methods, and accrediting bodies, who audit labs for compliance with ISO/IEC 17025, and industry specific quality system requirements

Characterization of triacontyl (C-30) liquid chromatographic columns

March 15, 2020

Author(s)

Lane C. Sander, Catherine A. Rimmer, Walter B. Wilson

Differences in the performance characteristics of seventeen commercial C30 liquid chromatographic columns were studied for the separation of carotenoid isomers. A mixture consisting of nine xanthophyll and hydrocarbon carotenoids were separated under

NIST Reference Materials: Their Purpose and Their Future

March 15, 2020

Author(s)

Steven J. Choquette, David L. Duewer, Katherine E. Sharpless

The National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards, was established by the U.S. Congress in 1901 and charged with establishing a measurement foundation to facilitate U.S. and international commerce. This

Disparate Metabolomics Data Reassembler: A Novel Algorithm for Agglomerating Incongruent LC-MS Metabolomics Datasets

March 2, 2020

Author(s)

Tytus D. Mak, Maryam Goudarzi, Evagelia C. Laiakis, Stephen E. Stein

In the past decade, the field of LC-MS based metabolomics has transformed from an obscure specialty into a major -omics platform for studying metabolic processes and biomolecular characterization. However, as a whole the field is still very fractured, as

Practical Guide for Inelastic Mean Free Paths, Effective Attenuation Lengths, Mean Escape Depths, and Information Depths in X-ray Photoelectron SpectroscopyInformation Depths in X-ray Photoelectron Spectroscopy

February 20, 2020

Author(s)

Cedric J. Powell

Information is provided on four terms that are used for different purposes in X-ray photoelectron spectroscopy (XPS): the inelastic mean free path (IMFP), the effective attenuation length (EAL), the mean escape depth (MED), and the information depth (ID)

Certification of Standard Reference Material(R) 2925: Recombinant Human Serum Albumin Solution (Primary Reference Calibrator for Urine Albumin) (Frozen)

February 19, 2020

Author(s)

Ashley B. Green, David M. Bunk, Nien F. Zhang, Wendell Alejo

This Standard Reference Material (SRM) is intended primarily for use in the preparation of calibration solutions for a candidate reference measurement procedure for human serum albumin (HSA) in human urine. This candidate reference measurement procedure is

New Insights into Female Humpback Whale (Megaptera novaeangliae) Reproductive Endocrinology Revealed by Steroid Hormone Profile Analysis

February 19, 2020

Author(s)

Greta Dalle Luche, Ashley Boggs, John Kucklick, Jasmin Gross, Darryl Hawker, Susan Bengston Nash

The blubber steroid hormone profiles of 52 female humpback whales migrating along the east coast of Australia were investigated for possible seasonal endocrinological changes associated with reproduction. Individuals were randomly sampled in southeast