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Development of a Cigarette Tobacco Filler Standard Reference Material



Lane C. Sander, Jeanita Pritchett, Laura J. Wood, Brian Lang, Stephen Wise, Matt J. Walters, T. Phillips, M. J. Holman, G. Lee, J. Lisko, B. Lane, L. Valentin, B. Kimbrell, S. Kuklenyik, S. Stanfill, C. Watson


A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified and reference mass fraction values for nicotine, N-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and volatiles. The constituents have been determined by multiple analytical methods with measurements at NIST and at the Centers for Disease Control and Prevention, and with confirmatory measurements by commercial laboratories. This effort highlights the development of the first Standard Reference Material for reduced nicotine and reduced tobacco-specific nitrosamines (TSNAs) with certified values for composition.
Analytical Chemistry


tobacco, standard reference material, SRM, nicotine, tobacco specific nitrosamine, TSNA, moisture


Sander, L. , Pritchett, J. , Wood, L. , Lang, B. , Wise, S. , Walters, M. , Phillips, T. , Holman, M. , Lee, G. , Lisko, J. , Lane, B. , Valentin, L. , Kimbrell, B. , Kuklenyik, S. , Stanfill, S. and Watson, C. (2017), Development of a Cigarette Tobacco Filler Standard Reference Material, Analytical Chemistry, [online], (Accessed May 22, 2024)


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Created September 20, 2017, Updated July 12, 2023