Development of a Cigarette Tobacco Filler Standard Reference Material

Published

September 20, 2017

Author(s)

Lane Sander, Jeanita Pritchett, Laura J. Wood, Brian Lang, Stephen Wise, Matt J. Walters, T. Phillips, M. J. Holman, G. Lee, J. Lisko, B. Lane, L. Valentin, B. Kimbrell, S. Kuklenyik, S. Stanfill, C. Watson

Abstract

A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified and reference mass fraction values for nicotine, N-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and volatiles. The constituents have been determined by multiple analytical methods with measurements at NIST and at the Centers for Disease Control and Prevention, and with confirmatory measurements by commercial laboratories. This effort highlights the development of the first Standard Reference Material for reduced nicotine and reduced tobacco-specific nitrosamines (TSNAs) with certified values for composition.

Citation

Analytical Chemistry

Volume

89

Pub Type

Journals

Download Paper

https://doi.org/10.1021/acs.analchem.7b02550

Local Download

Keywords

tobacco, standard reference material, SRM, nicotine, tobacco specific nitrosamine, TSNA, moisture

Citation

Sander, L. , Pritchett, J. , Wood, L. , Lang, B. , Wise, S. , Walters, M. , Phillips, T. , Holman, M. , Lee, G. , Lisko, J. , Lane, B. , Valentin, L. , Kimbrell, B. , Kuklenyik, S. , Stanfill, S. and Watson, C. (2017), Development of a Cigarette Tobacco Filler Standard Reference Material, Analytical Chemistry, [online], https://doi.org/10.1021/acs.analchem.7b02550, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=922986 (Accessed October 22, 2025)