Schock, T.
, Moeller, P.
, Belisle, R.
, Via, C.
, Villareal, T.
, Beauchesne, K.
, Bertin, M.
and Zimba, P.
(2017),
Trichothiazole A, a dichlorinated polyketide featuring an embedded thiazole isolated from Trichodesmium thiebautii blooms, Tetrahedron Letters
(Accessed October 8, 2025)
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Trichothiazole A, a dichlorinated polyketide featuring an embedded thiazole isolated from Trichodesmium thiebautii blooms
Published
Author(s)
, Peter D. Moeller, Rick Belisle, Christopher W. Via, Tracy A. Villareal, Kevin Beauchesne, Matthew J. Bertin, Paul Zimba
Abstract
Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium thiebautii bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4- disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2A cells (EC50: 13.3 ± 1.1 μM).Citation
Tetrahedron Letters
Pub Type
Journals
Keywords
heterocycles, thiazole, Trichodesmium thiebautii
Citation
Issues
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Created September 18, 2017, Updated February 4, 2020