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Bioscience

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Displaying 1076 - 1100 of 1280

An MD/QM Study of the Chorismate Mutase-Catalyzed Claisen Rearrangement Reaction

July 1, 2001
Author(s)
S. E. Worthington, A. E. Roitberg, Morris Krauss
The reaction path for the rearrangement of chorismate to prephenate, catalyzed by chorismate mutase, has been calculated with ab initio quantum chemistry. The calculation of a reaction path is initiated from two catalytically competent conformations of the

The Claisen Rearrangement of an Unusual Substrate in Chorismate Mutase

July 1, 2001
Author(s)
S. E. Worthington, Morris Krauss
The calculated reaction path for an unusual substrate of chorismate mutase (Bacillus.subtilis) is found to be completely comparable to that of the native chorismate. In the unusual substrate, the cyclohexadienyl ring in chorismate is replaced by

Reference Materials for DNA Analysis

March 1, 2001
Author(s)
Barbara C. Levin, D J. Reeder
Mention has already been made, in Section 5.1. Of the use of DNA-based techniques for control of microbiological DNA. In parallel to the work of ATCC the USA National Institute of Standards and Technology (NIST) developed three Standard Reference Materials

The Development of Fluorescence Intensity Standards

March 1, 2001
Author(s)
Adolfas K. Gaigalas, L. Li, O. Henderson, R F. Vogt, J. Barr, G E. Marti, J. Weaver, A. Schwartz
The use of fluorescence as an analytical technique has been growing over the last 20 years. A major factor in inhibiting more rapid growth has been the inability to make comparable fluorescence intensity measurements across laboratories. NIST recognizes

Ab Initio Structure of the Active Site of Phosphotriesterase

February 1, 2001
Author(s)
Morris Krauss
This research exploits two recent developments to obtain a fundamental understanding of the metalloenzyme active site using the bi-metallic enzyme phosphotriesterase as an example of this class. First, is the theoretical prediction that the structure and

CASSCF Investigation of Electronic Excited States of 2-Aminopurine

January 11, 2001
Author(s)
E L. Rachofsky, J B. Ross, Morris Krauss, R Osman
2-aminopurine is a highly fluorescent analog of adenine that can be incorporated synthetically into DNA with little perturbation of the native double-helical structure. The sensitive dependence of the quantum yield of this fluorophore on nucleic acid

A new approach to assess mAb aggregation

January 1, 2001
Author(s)
Illarion Turko
A proof-of-concept for new methodology to detect and potentially quantify mAb aggregation is presented. Assay development included using an aggregated mAb as bait for screening of a phage display peptide library and identifying those peptides with random
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