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Bioscience

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Displaying 1051 - 1075 of 1250

Reference Materials for DNA Analysis

March 1, 2001
Author(s)
Barbara C. Levin, D J. Reeder
Mention has already been made, in Section 5.1. Of the use of DNA-based techniques for control of microbiological DNA. In parallel to the work of ATCC the USA National Institute of Standards and Technology (NIST) developed three Standard Reference Materials

The Development of Fluorescence Intensity Standards

March 1, 2001
Author(s)
Adolfas K. Gaigalas, L. Li, O. Henderson, R F. Vogt, J. Barr, G E. Marti, J. Weaver, A. Schwartz
The use of fluorescence as an analytical technique has been growing over the last 20 years. A major factor in inhibiting more rapid growth has been the inability to make comparable fluorescence intensity measurements across laboratories. NIST recognizes

Ab Initio Structure of the Active Site of Phosphotriesterase

February 1, 2001
Author(s)
Morris Krauss
This research exploits two recent developments to obtain a fundamental understanding of the metalloenzyme active site using the bi-metallic enzyme phosphotriesterase as an example of this class. First, is the theoretical prediction that the structure and

CASSCF Investigation of Electronic Excited States of 2-Aminopurine

January 11, 2001
Author(s)
E L. Rachofsky, J B. Ross, Morris Krauss, R Osman
2-aminopurine is a highly fluorescent analog of adenine that can be incorporated synthetically into DNA with little perturbation of the native double-helical structure. The sensitive dependence of the quantum yield of this fluorophore on nucleic acid

A new approach to assess mAb aggregation

January 1, 2001
Author(s)
Illarion Turko
A proof-of-concept for new methodology to detect and potentially quantify mAb aggregation is presented. Assay development included using an aggregated mAb as bait for screening of a phage display peptide library and identifying those peptides with random

Gene Expression Analysis on Medium-Density Oligonucleotide Arrays

January 1, 2001
Author(s)
R. Sinibaldi, C D. O'Connell, H Rodriguez, C. Seidel
As the human genome project continues toward its goal of sequencing the entire human genome by the end of 2003, this is providing unique opportunities for studying genetic variation in humans and its relationship with disease risk and aging. Consequently

Estimation of the Hydrophobic Effect in an Antigen-Antibody Protein-Protein Interface

December 19, 2000
Author(s)
E. J. Sundberg, M. Urrutia, B C. Braden, J. Isern, D. Tsuchiya, B. A. Fields, E Malchiodi, J. Tormo, Frederick P. Schwarz, R A. Mariuzza
Antigen-antibody complexes provide useful models for analyzing the thermodynamics of protein-protein association reactions. We have employed site-directed mutagenesis, X-ray crystallography, and isothermal titration calorimetry to investigate the role of
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