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Bioscience

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Displaying 1026 - 1050 of 1261

Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA

February 1, 2002
Author(s)
Pawel Jaruga, R Jabil, Amanda K. McCullough, H Rodriguez, M Miral Dizdar, R S. Lloyd
A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identity

Chorismate Lyase: Kinetics and Engineering for Stability

January 31, 2002
Author(s)
Marcia J. Holden, M P. Mayhew, David T. Gallagher, V L. Vilker
By removing the enolpyruvyl group from chorismate, chorismate lyase (CL) produces p-hydroxybenzoate (p-HB) for the ubiquinone biosynthetic pathway. We have analyzed CL by several spectroscopic and chemical techniques and measured its kinetic (k cat = 1.7x

Determination of Active Site Residues in Escherichia Coli Endonuclease VIII

January 25, 2002
Author(s)
S. M. Burgess, Pawel Jaruga, M L. Dodson, Miral M. Dizdar, R S. Lloyd
Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple

Standardization of PCR Amplification for Fragile X Trinucleotide Repeat Measurements

January 1, 2002
Author(s)
C D. O'Connell, Donald H. Atha, J P. Jakupciak, Kristy L. Richie
To provide the clinical diagnostics community with accurate protocols and measurements for the detection of genetic disorders, we have established a quantitative a quantitative measurement program for trinucleotide repeats associated with human disease. In

Dominant Thermodynamic Role of the Third Independent Receptor Binding Site in the Receptor-Associated Protein RAP

December 18, 2001
Author(s)
O M. Andersen, Frederick P. Schwarz, Edward Eisenstein, C Jacobsen, S K. Moestrup, M Etzerodt, H C. Thogersen
The 39 Kda receptor-associated protein (RAP) is a three-domain escort protein in the secretory pathway for several members of the low-density lipoprotein receptor (LDLR) family of endocytic receptors, including the LDLR-related protein (LRP). The minimal

The Cockayne Syndrome Group B Gene Product is Involved in General Genome Base Excision Repair of 8-hydroxyguanine in DNA

December 7, 2001
Author(s)
J Tuo, M Muftuoglu, C Chen, Pawel Jaruga, R R. Selzer, R M. Brosh, H Rodriguez, Miral M. Dizdar, V. Bohr
Cockayne Syndrome (CS) is a human genetic disorder with two complementation groups, CS-A and CS-B. The CSB gene product is involved in transcription-coupled repair of DNA damage but may participate in other pathways of DNA metabolism. The present study

Development of Y STR Megaplex Assays

December 1, 2001
Author(s)
R Schoske, John Butler, Peter Vallone, Margaret C. Kline, M. Prinz, A J. Redd, M F. Hammer
Y Chromosome short tandem repeat markers have a number of applications in human identity testing including typing the perpetrator of sexual assault cases without differential extraction and tracing paternal lineages for missing person investigations. In

Turkish Population Data With the CODIS Multiplex Short Tandem Repeat Loci

December 1, 2001
Author(s)
B S. Akbasak, B. Budowle, D J. Reeder, J Redman, Margaret C. Kline
Allele frequencies for thirteen tetrameric short tandem repeat (STR) loci, CSF1PO, D18S51, D3S1358, D21S11, D5S818, FGA, D7S820, HUMTH01, D8S1179, TPOX, D13S317, VWA, and D16S539 were determined on 198 Turkish blood samples.

Intron and Exons

October 17, 2001
Author(s)
Arlin B. Stoltzfus
An intron (or intervening sequence) is a segment of RNA excised from a gene transcript, with concomitant ligation of flanking segments called exons. Introns of some type are found in every kingdom of cellular life, and also in viruses, bacteriophages and

Temperature Measurement and Control in Microfluidic Systems

October 1, 2001
Author(s)
David J. Ross, Michael Gaitan, Laurie E. Locascio
We describe a technique for the measurement of fluid temperatures in microfluidic systems based on temperature-dependent fluorescence. The technique is easy to implement with a standard fluorescence microscope and CCD camera. The efficiency of the method
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