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Bioscience

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  • Published Date
Displaying 1026 - 1050 of 1242

Temperature Measurement and Control in Microfluidic Systems

October 1, 2001
Author(s)
David J. Ross, Michael Gaitan, Laurie E. Locascio
We describe a technique for the measurement of fluid temperatures in microfluidic systems based on temperature-dependent fluorescence. The technique is easy to implement with a standard fluorescence microscope and CCD camera. The efficiency of the method

The Crystal Structure of Chorismate Lyase Shows a New Fold and a Tightly Retained Product

August 15, 2001
Author(s)
David T. Gallagher, M P. Mayhew, Marcia J. Holden, A J. Howard, K J. Kim, V L. Vilker
The enzyme chorismate lyase (CL) catalyzes the removal of pyruvate from chorismate to produce 4-hydroxy benzoate (4HB) for the ubiquinone pathway. In Escherichia coli, CL is monomeric with 164 residues; we have determined the structure of the CL product

Raman and FTIR Spectroscopies of Fluorescein in Solutions

August 1, 2001
Author(s)
Lili Wang, A. E. Roitberg, Curtis W. Meuse, Adolfas K. Gaigalas
Raman and FTIR transform-infra red (FT-IR) spectroscopies of fluorescein in aqueous solutions have been investigated in the pH range from 9.1 to 5.4. At pH 9.1 fluorescein is in the dianion form. At pH 5.4, fluorescein is a mixture of monoanion (

An MD/QM Study of the Chorismate Mutase-Catalyzed Claisen Rearrangement Reaction

July 1, 2001
Author(s)
S. E. Worthington, A. E. Roitberg, Morris Krauss
The reaction path for the rearrangement of chorismate to prephenate, catalyzed by chorismate mutase, has been calculated with ab initio quantum chemistry. The calculation of a reaction path is initiated from two catalytically competent conformations of the

The Claisen Rearrangement of an Unusual Substrate in Chorismate Mutase

July 1, 2001
Author(s)
S. E. Worthington, Morris Krauss
The calculated reaction path for an unusual substrate of chorismate mutase (Bacillus.subtilis) is found to be completely comparable to that of the native chorismate. In the unusual substrate, the cyclohexadienyl ring in chorismate is replaced by
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