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Bioscience

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Displaying 801 - 825 of 1280

Characterization of gold nanoparticles modified with single-stranded DNA using analytical ultracentrifugation and dynamic light scattering

August 3, 2010
Author(s)
James Falabella, Tae Joon Cho, Dean C. Ripple, Vincent A. Hackley, Michael J. Tarlov
We report the characterization of gold nanoparticles modified with thiol-terminated single stranded DNA using analytical ultracentrifugation and dynamic light scattering. Sedimentation coefficients of nominally 10 and 20 nm diameter gold nanoparticles

Preparation and Characterization of Standard Reference Material 1849 Infant/Adult Nutritional Formula

July 1, 2010
Author(s)
Katherine E. Sharpless, Richard M. Lindstrom, Bryant C. Nelson, Karen W. Phinney, Catherine A. Rimmer, Lane C. Sander, Michele M. Schantz, Rabia Oflaz, Jeanice M. Brown Thomas, Gregory C. Turk, Stephen A. Wise, Laura J. Wood, James H. Yen
Standard Reference Material (SRM) 1849 Infant/Adult Nutritional Formula has been issued by the National Institute of Standards and Technology (NIST) as a replacement for SRM 1846 Infant Formula, which was issued in 1996. Extraction characteristics of SRM

Quantum Dot FRET Sensor for Enzymatic Activity in Microfluidic Device

June 22, 2010
Author(s)
Georgeta Crivat, Sandra M. Da Silva, Darwin Reyes-Hernandez, Samuel Forry, Laurie E. Locascio, Michael Gaitan, Nitsa Rosenzweig, Zeev Rosenzweig
This paper describes the development of new fluorescence resonance energy transfer (FRET)-based quantum dot probes for proteolytic activity. The CdSe/ZnS quantum dots are incorporated into a thin polymeric film, which is prepared by layer-by-layer

FRACTURE OF TOOTH ENAMEL FROM INCIPIENT MICROSTRUCTURAL DEFECTS

June 14, 2010
Author(s)
H Chai, James J. Lee, Brian R. Lawn
We present definitive evidence for crack growth from internal defects called 'tufts' in human enamel. Side walls of slices sawn from extracted human teeth are observed during loading to 'failure'. 'Longitudinal' and 'transverse' slices (parallel and normal

Solutions for Determining Equibiaxial Substrate Strain for Dynamic Cell Culture

May 2, 2010
Author(s)
Martin Y. Chiang, Tianle Cheng, Lisa Pakstis, Joy P. Dunkers
Empirical and analytical solutions are derived in this study to determine the equibiaxial strain on a flexible substrate upon which the cells can be cultured. The empirical formula is based on the mechanistic constraint and a regression analysis of results

Monitoring and Controlling Oxygen Levels in Microfluidic Devices

April 30, 2010
Author(s)
Samuel Forry, Peter C. Thomas, Srinivasa R. Raghavan
Mammalian cell culture has been traditionally performed in a static oxygen concentration of 20 mol %. However, oxygen level in vivo is significantly more hypoxic with an average oxygen concentration of 3 mol % to 5 mol %. In addition, many cells within the

Prediction of Collagen and Glycosaminoglycan Content by Acoustic Microscopy

April 21, 2010
Author(s)
Jenni R. Popp, Colm Flannery, Tammy L. Oreskovic, Jennifer Recknor, Kristi S. Anseth, Timothy P. Quinn
Functional tissue engineering of articular cartilage is rapidly advancing as a technique to develop regenerative and reparative treatments for cartilage degeneration and osteoarthritis. Tissue engineered constructs are often developed using a combination

RECIST vs. Volume Measurement in Medical CT Using Ellipsoids of Known Size

April 12, 2010
Author(s)
Zachary H. Levine, Bruce R. Borchardt, Nolan J. Brandenburg, Charles W. Clark, Balasubramanian Muralikrishnan, Craig M. Shakarji, Joseph J. Chen, Eliot L. Siegel
(a) Purpose: We wanted to test the extent to which two common methods of determining the sizes of tumors would perform when compared to a statistically significant number of well-characterized reference objects. The size of the objects was chosen to

Teeth: Among Nature's Most Durable Biocomposites

April 6, 2010
Author(s)
Brian R. Lawn, James J. Lee, H Chai
This paper addresses the durability of natural teeth from a materials perspective. Teeth are depicted as 'smart' biocomposites, highly resistant to cumulative deformation and fracture. Favorable morphological features of teeth at both macroscopic and

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo

March 16, 2010
Author(s)
Minin Liu, Viswanath Bandaru, Jeffrey Bond, Pawel Jaruga, Xiaobei Zhao, Plamen P. Christov, Cynthia Burrows, Carmelo J. Rizzo, Miral M. Dizdar, Susan Wallace
To protect cells from oxidative DNA damage and mutagenesis, organisms possess multiple glycosylases to recognize the damaged bases and to initiate the Base Excision Repair (BER) pathway. Recently, three DNA glycosylases were identified in mammals that are

Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications

February 18, 2010
Author(s)
Mark M. Bailey, Christine M. Mahoney, Elodie Dempah, Jeffrey M. Davis, Matthew Becker, Supang Khondee, Eric J. Munson, Cory J. Berkland
Nanomaterials have emerged as valuable tools in biomedical imaging techniques, such as magnetic resonance imaging (MRI), fluorescence, positron emission tomography (PET), and others. Some have been designed to serve as multimodal imaging agents, combining

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate specificities from their Escherichia coli counterparts

February 4, 2010
Author(s)
Yin Guo, Viswanath Bandaru, Pawel Jaruga, Xiaobei Zhao, Cynthia Burrows, Shigenori Iwai, Miral M. Dizdar, Jeffrey Bond, Susan Wallace
The DNA glycosylases function in the first step of the base excision repair process that is responsible for removing endogenous oxidative purine and pyrimidine damages from DNA. The DNA glycosylases that remove oxidized DNA bases fall into two general

Three steps towards metrological traceability for ballistics signature measurements

February 1, 2010
Author(s)
Jun-Feng Song, Theodore V. Vorburger, Robert M. Thompson, Thomas Brian Renegar, Xiaoyu Alan Zheng, Li Ma, James H. Yen, Martin Ols
The National Institute of Standards and Technology (NIST) in collaboration with the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF) has developed the Standard Reference Material (SRM) 2460 bullets and 2461 casings. NIST and ATF are proposing to

Volumetric CT in Lung Cancer: An Example for the Qualification of Imaging as a Biomarker

January 9, 2010
Author(s)
Charles D. Fenimore, Andrew Buckler, P. David Mozeley, Lawrence H. Schwartz, Nicholas Petrick, Michael McNitt-Gray, Kevin O?Donnell, Wendy Hayes, Hyun Kim, Laurence Clarke, Daniel Sullivan
The Quantitative Imaging Biomarker Alliance (QIBA) has been organized to establish a methodology whereby multiple stakeholders collaborate to test hypotheses about the technical feasibility and the medical value of imaging biomarkers. It has charged the

In-plane Homogeneity and Lipid Dynamics in tethered Bilayer Lipid Membranes (tBLMs)

January 1, 2010
Author(s)
Siddharth Shenoy, Radu Moldovan, James Fitzpatrick, David J. Vanderah, Markus Deserno, Mathias Losche
Tethered bilayer lipid membranes (tBLMs) were prepared by the self-assembly of thiolated lipidic anchors on gold films sputtered on Si wafers, followed by phospholipid precipitation via rapid solvent exchange. They were characterized in their in-plane

Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions

December 1, 2009
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D)

Chemical Science and Technology Laboratory (CSTL) 2009 Annual Report

November 17, 2009
Author(s)
Willie E. May, Richard R. Cavanagh, Dianne L. Poster, Michael D. Amos
CSTL is entrusted with building, sustaining, and maximizing the chemical measurement system that is criticial to chemical technological innovation, economic competitiveness and new job growth for the benefit of the Nation.
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