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Bioscience

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Displaying 826 - 850 of 1221

The Role of Water in the Thermodynamics of Drug Binding to Cyclodextrin

July 1, 2007
Author(s)
Niya Tordorova, Frederick P. Schwarz
The thermodynamic parameters, DBGo, DBHo, and DBSo, of the drugs flurbiprofen (FLP), nabumetone (NAB), and naproxen (NPX) binding to b-cyclodextrin (bCD) and to g-cyclodextrin (gCD) in 0.10 M sodium phosphate buffer were determined from isothermal

Recent Developments of the HLPR Chair

June 15, 2007
Author(s)
Roger V. Bostelman, James S. Albus, Tommy Chang
The Home Lift, Position and Rehabilitation (HLPR) Chair, developed at the National Institute of Standards and Technology (NIST) within the Intelligent Systems Division (ISD) from 2005 to 2006, is currently being evaluated for static stability using

Cholesterol/Phospholipid Interactions in Hybrid Bilayer Membranes

May 25, 2007
Author(s)
Dustin Levy, Kimberly Briggman
The interactions between cholesterol and saturated phospholipids in hybrid bilayer membranes (HBMs) were investigated using the interface-sensitive technique of vibrational sum frequency spectroscopy (VSFS). The unique sensitivity of VSFS to order/disorder

A new model of pulse oximetry: Two-dimensional pulsation

March 14, 2007
Author(s)
Shao Yang, Paul B. Batchelder, Dena M. Raley
We developed a two-dimensional pulsation model of pulse oximetry. Instead of a one-dimensional single layer as in the conventional theory, the arteries pulsate in two dimensions taking into account the effect of probing light that does not pass through the

The Stiffness of Collagen Fibrils Influences Vascular Smooth Muscle Cell Phenotype

March 1, 2007
Author(s)
Dennis P. McDaniel, Gordon A. Shaw, John T. Elliott, Kiran Bhadriraju, Curtis W. Meuse, Koo-Hyun Chung, Anne L. Plant
Cells receive signals from the extracellular matrix through receptor-dependent interactions, but they are also influenced by the mechanical properties of the matrix. While bulk properties of substrates have been shown to effect cell behavior, we show here

Counter-Flow Gradient Electrofocusing

February 1, 2007
Author(s)
Jonathan G. Shackman, David J. Ross
Counter-flow gradient electrofocusing methods are methods whereby a combination of electrophoresis and a bulk solution counter-flow is used to accumulate or focus analytes at stationary points along a separation column. This review first describes the

Characterization and Control of Lipid Layer Fluidity in Hybrid Bilayer Membranes

January 31, 2007
Author(s)
Neil A. Anderson, Lee J. Richter, John C. Stephenson, Kimberly A. Briggman
The main gel-to-liquid-crystal (LC) phase transition temperature, Tm, of the distal lipid layer in hybrid bilayer membranes (HBMs) under water was investigated using vibrational sum frequency spectroscopy (VSFS). VSFS has unique sensitivity to order

Analysis of potential cancer biomarkers in mitochondrial DNA

December 1, 2006
Author(s)
J P. Jakupciak, G. D. Dakubo, Samantha D. Maragh, R. L. Parr
Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer, rare metabolic diseases, aging, the tracing of human

NMR Analysis of Rhodopsin-Transducin Interactions

December 1, 2006
Author(s)
Kevin Ridge, John Marino, T Ngo, Eva Ramon, D M. Brabazon, N G. Abdulaev
Heterotrimeric G-protein activation by an agonist-stimulated G-protein coupled receptor (R*) requires the propagation of structural signals from the receptor interacting surfaces to the guanine nucleotide-binding pocket. Employing high-resolution NMR

Determination of Lipid Phase Transition Temperatures in Hybrid Bilayer Membranes

September 9, 2006
Author(s)
Neil A. Anderson, Lee J. Richter, John C. Stephenson, Kimberly A. Briggman
The main gel to liquid crystal (LC) phase transition temperature, Tm, of the lipid monolayers in hybrid bilayer membranes (HBMs) was investigated using vibrational sum frequency spectroscopy (VSFS). The unique sensitivity of VSFS to probe order/disorder
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