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Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

Published

Author(s)

Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young

Abstract

There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone marrow stromal cell (hBMSC) differentiation and proliferation change in response to change in stiffness of the underlying substrate. Herein, the effect of matrix modulus on differentiation of hBMSC within three-dimensional (3D) polyethylene glycol tetramethacrylate (PEGTM) hydrogel scaffolds is examined.
Proceedings Title
RESBIO Cells on Polymeric Biomaterials
Conference Dates
October 26-29, 2010
Conference Location
Piscataway, NC

Keywords

tissue engineering, hydrogel scaffold, stem cell, cell differentiation, modulus

Citation

Simon, C. , Parekh, S. , Cicerone, M. , Lin-Gibson, S. , Chatterjee, K. and Young, M. (2010), Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation, RESBIO Cells on Polymeric Biomaterials, Piscataway, NC, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=906309 (Accessed May 25, 2022)
Created November 1, 2010, Updated February 19, 2017