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Biophysical and Biomedical Measurement Group

Advancing measurement science, fabrication, and technology to enable the quantification of biological phenomena across scales, from single molecules and cells to tissues.

The Biophysical and Biomedical Measurement Group engineers and fabricates custom chips and sensors that measure cellular properties, cell-material and cell-cell interactions, tissue responses to drugs, metabolic processes, and basic metrology of biological systems (pressure, flow, size, temperature, optical, electrical, mechanical properties).  Our projects and programs support innovation and commercialization of cell-based measurement tools (e.g. organ-on-chip, flow cytometry), cell-derived therapies (e.g. stem cell, CAR T cells), and biomonitoring/control systems (e.g. drug delivery).  They also provide a foundation toward future growth into the areas of wearable and implantable devices (wireless communication, sensors, flexible materials) as well as quantitative imaging and sensing (linking chemical with physical information).  Overall, the Biomedical Microtechnologies group aims to produce devices that allow biomedical researchers, in both basic and applied settings, access to improved measurement methods and platforms that will enable the future bioeconomy.

News and Updates

Projects and Programs

Multi-Organ Microphysiological Systems

Ninety percent of clinical trials fail because - despite prior testing with animals - new drugs are often not effective or they turn out to be too toxic. We are

Dynamic Nanoflow Metrology

Current work, within the NIST on a Chip Program, includes developing microfluidic systems that improve the accuracy of flow measurements, which are fundamental

Nanostructures for Energy Conversion

Electrochemical systems containing nanostructured materials are increasingly being incorporated into devices for efficiently harvesting, storing, and converting

Publications

Matching and comparing objects in a serial cytometer

Author(s)
Nikita Podobedov, Matthew DiSalvo, Jason A. Hsu, Paul N. Patrone, Gregory A. Cooksey
Flow cytometers are indispensable for clinical studies, yet are hindered by inherent uncertainties. We have developed an optofluidic device capable of multiple

Software

MOSAIC

MOSAIC is a modular single-molecule analysis toolbox to decode multi-state single-molecule and nanopore time-series data. Read the documentation for additional

Awards

Contacts

Group Leader

Group Secretary