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Biophysical and Biomedical Measurement Group

Advancing measurement science, fabrication, and technology to enable the quantification of biological phenomena across scales, from single molecules and cells to tissues.

The Biophysical and Biomedical Measurement Group engineers and fabricates custom chips, sensors, and nanostructures that enable measurements across scales from the biomolecular to cellular and tissue levels. These devices and systems provide the means to quantify dynamic biological phenomena of single molecules and molecular ensembles, cellular properties, cell-material and cell-cell interactions, tissue responses to drugs, and metabolic processes, as well as provide basic metrology for biomedical systems (pressure, flow, size, temperature, optical, electrical, and mechanical properties). Our projects and programs support innovation and commercialization of cell-based measurement tools (e.g., organ-on-chip and flow cytometry), cell-derived therapies (e.g., stem cell and CAR T cells), and biomonitoring/control systems (e.g., drug delivery). Moreover, they serve as a foundation for future growth in wearable and implantable devices (wireless communication, sensors, and flexible materials), as well as quantitative imaging and sensing, including linking chemical with physical information. We also develop fundamental measurement techniques and supporting theoretical frameworks for biological processes at the biomolecular level, such as conformational transitions during signaling, activation, and drug metabolism. Many of these techniques incorporate biological elements into nanoscale and microscale devices for high-sensitivity detection and characterization of analytes (biomolecules, drugs, metabolites, ions, and other molecular matter) and sequencing of nucleic acids and proteins. Overall, the Group aims to produce devices that allow biologists and biomedical researchers, in both basic and applied settings, access to advanced measurement methods and platforms that promote innovation in the future bioeconomy and improve quality of life.

News and Updates

Projects and Programs

Electronic Biophysical Measurements

Chipscale electronic devices such as field-effect transistors (FETs) are being developed for biochemical applications ranging from clinical diagnostics to

Sensing, Transport, and Simulation

The transport of particles through a region of space acquires an imprint of local information that enables sensing, such as detecting the presence of a

Publications

Nanopore sensing: a physical-chemical approach

Author(s)
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes

Matching and comparing objects in a serial cytometer

Author(s)
Nikita Podobedov, Matthew DiSalvo, Jason A. Hsu, Paul Patrone, Gregory A. Cooksey
Flow cytometers are indispensable for clinical studies, yet are hindered by inherent uncertainties. We have developed an optofluidic device capable of multiple

Software

MOSAIC

MOSAIC is a modular single-molecule analysis toolbox to decode multi-state single-molecule and nanopore time-series data. Read the documentation for additional

Awards

Contacts

Group Leader

Group Secretary