A pumpless microfluidic device with passive valves (A) enables growth of functionally & structurally competent endothelial cells under unidirectional flow (B), and endothelial cell activation under bidirectional flow (C).
The Biomedical Microtechnologies Goup engineers and fabricates custom chips and sensors that measure cellular properties, cell-material and cell-cell interactions, tissue responses to drugs, metabolic processes, and basic metrology of biological systems (pressure, flow, size, temperature, optical, electrical, mechanical properties). Our projects and programs support innovation and commercialization of cell-based measurement tools (e.g. organ-on-chip, flow cytometry), cell-derived therapies (e.g. stem cell, CAR T cells), and biomonitoring/control systems (e.g. drug delivery). They also provide a foundation toward future growth into the areas of wearable and implantable devices (wireless communication, sensors, flexible materials) as well as quantitative imaging and sensing (linking chemical with physical information). Overall, the Biomedical Microtechnologies group aims to produce devices that allow biomedical researchers, in both basic and applied settings, access to improved measurement methods and platforms that will enable the future bioeconomy.