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Gregory A Cooksey (Fed)

Microfluidic cytometer
Microfluidic cytometer with integrated optical fibers (blue) that delivery light to and collect light from multiple interrogation regions inside the chip.

Dr. Cooksey’s laboratory at NIST focuses on creating microfluidic tools to improve measurements and enable discoveries in biomedical and clinical research.   His group has recently focused on developing new approaches to measure optical properties of cells and materials in flow, such as fluorescently tagged biomarkers. The group recently demonstrated highly accurate measurement of volumetric flow rates (e.g. 10 nL/min with 5 % uncertainty) by linking fluorescent properties of materials to the dosage of light they receive while flowing through an optical interrogation region.  These devices are also being advanced to make highly reproducible measurements of single cells in flow (cytometry).  His work is part of the NIST on a Chip program and a NIST Innovation in Measurement Science (IMS) award to revolutionize measurement capabilities of single cells in custom microfluidic cytometers.

Greg Cooksey joined NIST in 2007 as a National Research Council postdoctoral fellow and is a biomedical engineer and Project Leader in the Microsystems and Nanotechnology Division.  Prior to NIST he was a graduate student and postdoctoral researcher at the University of Washington, where he developed surfaces and devices to study migrating cells and neurons.

Member Of

SELECTED PROGRAMS/PROJECTS

Research Opportunities Available

lab on a chip cover

Potential Research Topics include:

  • Optofluidic cytometry design and characterization
  • Flow metrology; picoliter per minute measurements and dynamics
  • Microdroplet packaging and measurement
  • Cell-based microfluidic assays/diagnostics
  • Physical modeling, e.g. of dynamic systems in flow
  • Design of novel microfluidic functionalities

We encourage interested post-doctoral and graduate research candidates to contact us to discuss project opportunities and fellowships.  

Click here to go to our project listing with the National Research Council (NRC) 

Click here to find out how to apply for an NRC Postdoctoral Fellowship

Summer research opportunities for undergraduates (SURF Program) and high school students (SHIP Program) may also be available.  

Please contact me for more details or to discuss other ways to work together.

Publications

Matching and comparing objects in a serial cytometer

Author(s)
Nikita Podobedov, Matthew DiSalvo, Jason A. Hsu, Paul N. Patrone, Gregory A. Cooksey
Flow cytometers are indispensable for clinical studies, yet are hindered by inherent uncertainties. We have developed an optofluidic device capable of multiple

The Art in Science of MicroTAS 2019†

Author(s)
Gregory A. Cooksey
The 2019 MicroTAS conference (the 23rd International Conference of Miniaturized Systems for Chemistry and Life Sciences) held in Basel, Switzerland, brought

Patents

Exploded schematic shows line drawings of five layers inside the optofluidic flow meter.

Optofluidic Flow Meter

NIST Inventors
Zeeshan Ahmed and Gregory A Cooksey
The NIST optical flow meter uses a photonic sensor to detect pressure changes inside a microfluidic channel, which is then used to calculate volumetric flow rates. It provides on-chip assessment of flow and heat transfer resulting in improvement in fluid metrology and advances in biological sensing.
Created September 24, 2019, Updated June 15, 2021