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Metrology

Projects/Programs

Keyword

Organizational Unit

Electronic Material Characterization

Ongoing

Manufacturing optimized devices that incorporate newly-emerging materials requires predictable performance throughout device lifetimes. Unexpected degradation in device performance, sometimes leading to failure, is often traceable to poor material reliability. Reliability is rooted in the stability

Electron-Solid Interactions

Ongoing

A measuring instrument produces a signal that depends upon the value of the measurand. The value and its uncertainty are inferred from the signal by using a model of their relationship. Erroneous models lead to erroneous inference. The accuracy of SEM (scanning electron microscopy) is limited by

e-Statistics

Ongoing

Coming soon.

EUV Scatterometry

Ongoing

To measure and inspect the smallest printed features on an IC chip, researchers and manufacturers use a combination of electron scanning modalities (i.e., transmission electron and scanning electron microscopies) and an optical method, scatterometry. Industrially, the most common modality for

Evaluating Measurement Quality of Microfluidic Cell-based Assays

Completed

Impact and Customers Our work establishes metrics for measurement quality and reproducibility for cell-based assays within microfluidic devices. Many novel microfluidic devices are being created that permit new measurements or enable new biological functions to be tested; however, characterizations

Evaluation of 2D and WBG Material Quality Toward Device Reliability

Ongoing

Two-dimensional (2D) and wide band gap (WBG) materials are some of the latest materials classes having the potential to be transformative because of their high carrier mobilities, tunable bandgap, and atomic-scale film thicknesses. Unexpected degradation and failure in device performance is often

Expression of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers

Ongoing

Measurement of intact proteins by mass spectrometry can be problematic. In order to make proteins more amenable to mass spectrometric detection, the proteins are commonly digested with a proteolytic enzyme prior to analysis. Quantitation can then be performed by adding known amounts of isotopically

Extreme Atom Probe Tomography

Ongoing

Sub-nanometer-resolved 3-D chemical mapping of any atom in any solid continues to be an imperative goal of materials research. If reduced to practice, it would have profound scientific, engineering, and economic impacts on U.S. industries collectively worth hundreds of billions of dollars. Such

A high-finesse Fabry-Perot interferometer

Fabry-Perot Displacement Interferometry

Ongoing

Fabry-Perot interferometry has the highest resolution of any displacement sensor, below one picometer, and yet may be used to measure displacements of many centimeters. Equally important, it enables a natural and direct link to the SI unit of length, defined in terms of the speed of light. We are

Far infrared remote sensing

Ongoing

The Total Solar Irradiance and the outgoing Earth radiance are long term measurements that have been monitored from space for over 40 years. Microfabricated, absolutely calibrated bolometers with vertically-aligned carbon nanotubes that are developed by this project provide a more accurate and more

Schematic of four-arm digital impedance bridge

Farad and Impedance Metrology

Ongoing

The primary facility for connecting the U.S. legal system of electrical units to the international system of units is the NIST calculable capacitor, with which the measurement of capacitance is effectively achieved through a measurement of length. Both the calculable capacitor and the chain of high

Photograph of SRM 2378 Fatty Acids in Human Serum showing three vials labeled Serum 1, Serum 2, and Serum 3.

Fatty Acids in Human Serum and Plasma Quality Assurance Program (FAQAP)

Completed

Interlaboratory comparison studies of the FAQAP focused on the measurement of 24 fatty acids in selected serum and plasma matrices. Frozen or freeze-dried serum or plasma samples were sent to laboratories for analysis together with control materials. Results were returned to NIST for data evaluation

Field Programmable Gate Array (FPGA) Designs for Metrology

Ongoing

Until recently, the precision measurement of phase noise, spectral purity, and related quantities had been a challenging process, with only a handful of qualified experts in the world. However, Field Programmable Gate Array (FPGA) based measurement systems, similar to software defined radio (SDR)

Flow Cytometry Lab

Ongoing

Current Capabilities ERF value assignment measurement service for traceable ERF value assignment to microparticles, Aseptic sorting of cell lines, and primary cells Quantitative measurements of cell surface and intracellular biomarkers by estimating antibody bound per cell Accurate enumeration of

Fluid Phase Nuclear Magnetic Resonance (NMR) Spectroscopy

Ongoing

In-situ vapor-liquid equilibrium (VLE). We are applying vapor-phase NMR to measure VLE in-situ . We are currently applying this methodology to industrially important systems such as refrigerants and natural gas. The most widely used refrigerants have high global warming potential. Drop-in

Fluid Suspensions and Emulsions

Ongoing

We aim to: Develop measurement capabilities to relate solution structure and viscosity through novel combinations of unique small volume, high shear rate rheometers with scattering and particle-imaging techniques. A major application of these capabilities is understanding self-association in fluids

Food Nutrition and Safety Measurements Quality Assurance Program (FNSQAP)

Ongoing

As part of a revamp of QAPs in 2021, NIST established the FNSQAP to support the NIST Food Safety Program and Measurements and Standards to Support Nutrition Labeling. Participants measure nutrient components (e.g., minerals, vitamins, fatty acids, dietary fiber) and contaminants (e.g., toxic

The inside of a DNA extraction robot hold tube in a rack

Forensic Genetics

Ongoing

Since the late 1980s, NIST has had scientists involved in DNA testing (aka "DNA Fingerprinting"). Early concerns over measurement accuracy and poor quality control of forensic DNA tests caused the Department of Justice to call upon NIST scientists to help with standards development and technology

Fossil Fuel Standard Reference Materials

Ongoing

The regulatory requirements with respect to air quality and fossil fuel specifications are continually changing, and consequently the associated measurement needs of the fossil fuel energy industries also change. For example, in recent years there has been a dramatic reduction in the allowable

Frequency Measurement and Analysis Service (FMAS)

Ongoing

Subscribers to the NIST service receive a complete frequency measurement system which includes everything needed to make precision frequency measurements that are traceable to NIST. An easy-to-read instruction manual makes installation a snap. Once the system is installed, it's easy to get started

Fundamental Guided Wave Metrology

Ongoing

The science of microwave measurements is expanding in many different directions. There is a constant push to use higher frequencies. Signals are becoming much more complex and include modulation effects, multiport/differential signals, complex waveforms, and other unusual signal schemes. On-wafer

Fundamental Physics: Electric Field Imaging with Neutrons

Completed

An effective magnetic field B eff arises from the relativistic transformation of an electric field E into the frame of reference moving at the neutron velocity v; B eff is proportional to v x E /c 2, hence is small due to the factor of the square of the speed of light in the denominator. This

Fundamentals of Deformation

Ongoing

• We have provided general users from industry, academia and national laboratories with a completely new class of X-ray imaging techniques for materials studies (ultra-small-angle X-ray scattering imaging), that we developed from basic concept to DOE-supported operations at the Advanced Photon

Gas Flow and Properties: Standards and Models for Flow Metering Semiconductor Gases at Flows from 10 μL/min to 1 L/min

Ongoing

Today the control of process gases in semiconductor fabrication is highly empirical. The process is based on “recipes” for each step. The development of these recipes is a time-consuming process of trial and error, and each day in development can translate to many millions of dollars of lost

Gas properties for flow metering

Ongoing

NIST has two on-line databases that include accurate gas viscosity values: SEMIPROP - NIST Standard Reference Database 134 - for selected semiconductor process gases NIST Chemistry WebBook - for heat transfer fluids, components of air, components of natural gas [Note: as of February 2014, the NIST

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