Projects/Programs

Displaying 1 - 25 of 32

$Autonomous materials metrology diffraction measurement performed at SLAC$

Autonomous Systems for Materials Research and Metrology: Accelerating Discovery and Democratizing Science

Ongoing

We are developing novel machine learning algorithms and incorporating them into closed-loop autonomous systems to accelerate knowledge capture in the lab and in

Biomanufacturing Initiative

Ongoing

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Biosecurity for Synthetic Nucleic Acid Sequences

Ongoing

Balancing the growth of the bioeconomy with the inherent risks associated with the potential misuse of artificial intelligence (AI) related to nucleic acid

Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing

NIST is developing a portal to enable researchers to mine high-quality proteomic data from phylogenetically diverse species to identify advantageous biological

Comparative Serum Proteomics Project

Ongoing

Initially the Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program will generate proteomic data from sera from 25 different species that

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Blog detailing the renovation, retrofitting, and assembly of new type of metrology laboratory

Engineering Living Measurement Systems to Sense PFAS

Ongoing

The Cellular Engineering Group is working to engineer components of living cells to sense environmental fluctuations induced by contaminants within their

Engineering of G Protein-Coupled Receptors

Ongoing

We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune

Genome in a Bottle

Ongoing

Consortium hosted by NIST dedicated to authoritative characterization of benchmark human genomes. Sign up for General GIAB and Analysis Team email lists

HDX-MS for Biopharmaceutical Analysis

Ongoing

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Interpretable modeling of genotype-phenotype landscapes with state-of-the-art predictive power

Ongoing

Diverse biological sciences, from engineering to epidemiology, benefit from an increased understanding of how genetic code (genotype) determines downstream

MML researchers develop reference materials and methods for quantitative phase microscopy with off-the-shelf products

Measurement Assurance for Quantitative Cell Imaging by Optical Microscopy

Ongoing

S Mutans SEM image, in the process of forming complex networks.

Measurements for Microbial Ecology

Ongoing

Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such

Measurements for minimal cells

Ongoing

Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a

Absolute quantitation of mRNA molecules in bacterial cells

Methods for Absolute Quantitation of Transcription

Ongoing

Measurements of the performance of engineered organisms are typically not reproducible or comparable across different laboratories. So, to enable meaningful

Methods to determine the evolutionary stability of engineered biological function

Ongoing

Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require

Metrology For Cell-Free Expression Systems

Ongoing

The Cellular Engineering Group works to provide metrology for rapid, successful translation of safe, effective bioproducts based on cell-free expression systems

Next Generation Metrics for Cell-Based Therapies and Regenerative Medicines

Ongoing

NIST Cell-Free Workshop

Ongoing

The Cell-Free Workshop sought to identify and prioritize actionable steps towards more reproducible and comparable cell-free systems for practical applications

NIST Flow Cytometry Standards Consortium 

Ongoing

Flow cytometry is used to analyze individual cells to understand the proteins, nucleic acids and other biomolecules they have or produce, and to analyze groups

NIST Genome Editing Consortium

Ongoing

The National Institute of Standards and Technology Genome Editing Consortium addresses the measurements and standards needed to increase confidence and lower

NIST Genome Editing Program

Ongoing

Genome Editing technologies have transformed the potential of biosciences and biotechnology, by providing precision engineering tools that enable modifications

NIST Living Measurement Systems Foundry

Ongoing

The goal of the NIST Living Measurement Systems Foundry is to enable the engineering of cells for reliable and safe use in dynamic and unpredictable

NIST Monoclonal Antibody Reference Material 8671

Ongoing

NOW AVAILABLE The NIST monoclonal antibody (NISTmAb) reference material, RM 8671, is intended for use in evaluating the performance of methods for determining

TOP: Image of fluorescent reference material on microscope. BOTTOM: Charting of microscope control parameters.

Performance Benchmarking and Intensity Calibration of a Widefield Fluorescence Microscope

Ongoing

We have made available a method to characterize a fluorescence microscope's performance by benchmarking the detection threshold, saturation and linear dynamic

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