Comparative proteomics strives to gain insight into key underlying molecular changes that result in unique phenotypes across related taxa. Proteomic analysis complements comparative genomics by providing evidence of protein abundance, orthogonal to gene copy number and amount of transcript. In order to realize the potential of comparative proteomics in accelerating human biomedical discoveries, data across a swath of mammals must be acquired in a standardized fashion, though this has unique challenges at every step. NIST and its partners are uniquely situated to accomplish this by having access to unique and diverse samples, developing and defining standard protocols, acquiring data on state of the art instrumentation and providing a platform to disseminate the resulting data. This resource will be foundational to advances related to the bioeconomy and one health initiatives, and will provide an invaluable resource to biomedical researchers, governmental agencies, and software developers, accelerating development and discoveries.
Comparative proteomics is akin to how comparative medicine uses different animals as models of human disease, but in this case the goal of comparative proteomics (and biomimetic studies) is to study diverse species to better understand traits that may help mitigate injury that results in chronic human disease (e.g., acute kidney injury, stroke, myocardial infarction). Evolution of millions of species over billions of years has allowed a diversity of molecular solutions to exist to allow for adaptation and speciation. For instance, diving mammals are able to deal with ischemia/reperfusion stress and hibernating mammals avoid cardiac stress and avoid uremia. Due to the high degree of protein homology between mammalian species, humans often possess similar molecular machinery, and therefore insights are likely translatable to humans. The CoMPARe Program will generate data sets in a standardized fashion and develop a web portal for stakeholders to access and explore results in order to facilitate biomimetic discoveries and accelerate biomedical advances.
How to contribute
If you would like to learn more or assist with the project, please email firstname.lastname@example.org.
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