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Material Measurement Laboratory

Projects/Programs

Displaying 276 - 300 of 576
Food Triangle

Measurements and Standards to Support Nutrition Labeling

Ongoing
Well-characterized certified reference materials are needed by laboratories in the food testing and nutrition communities to facilitate compliance with labeling laws and improve the accuracy of information provided on product labels so that consumers can make good choices. As a result of the...

Measurements and Theory for Predicting Stem Cell Stability

Completed
Cell-based therapies require efficient manufacturing processes, as well as assurance of the safety and the stability of cellular products. However, our ability to predict the response of cells to environmental conditions is far from perfect. To move beyond empirical approaches, we are using...

Measuring Intermolecular Interactions with Electro-Acoustic Spectroscopy

Ongoing
We have a number of opportunities to collaborate with us. See below for details. What does this project aim to do for the chemical industry? Many industrial processes depend on the intermolecular environment- the solvents and ions that surround a molecule. These interactions impact separations...
Schematic of approach to clean water membranes

Membranes for Clean Water

Completed
Impact Access to affordable, clean water is vital to the nation's economic growth and security. Polymer-based membrane separation technologies based on reverse osmosis, forward osmosis and nanofiltration will play an increasingly critical role in the production of clean, safe water. In order to...
MANTA Logo

Method Assessment for Non-Targeted Analyses (MANTA) Program

Ongoing
Typical targeted analysis aims to detect and/or quantify a set of known chemical compounds using specific instrumental techniques (such as liquid chromatography with triple quadrupole mass spectrometry). In contrast, non-targeted analysis is an analytical technique that detects, identifies, and/or...
Absolute quantitation of mRNA molecules in bacterial cells

Methods for Absolute Quantitation of Transcription

Ongoing
The ability to engineer novel, useful functions into microbial cells for manufacturing or therapeutic applications has accelerated rapidly over the last few decades. However, the measurements required to underpin predictive engineering of these systems are typically not comparable across different...

Methods to Quantify Microbial Viability

Ongoing
Validating DNA-based methods to quantify viable bacteria ( S. Da Silva , G. Pinheiro) Microbial detection technologies based on nucleic acid measurements, such as polymerase chain reaction (PCR), are powerful detection tools that can provide relatively rapid results as compared to traditional...
A line drawing of a woman's head styled like a classical carved bust

METIS

Ongoing
A Metrology Exchange to Innovate in Semiconductors

Metrics for Reactive Wetting in Complex Systems

Completed
From fundamental physical considerations, we have derived a set of partial differential equations describing wetting and spreading. These equations are derived using a variational thermodynamic principle applied to a two-component alloy system with three (vapor, liquid and solid) phases. The method...

Metrologies for Non-linear Materials in Impact Mitigation

Ongoing
Overview This project develops fundamental structure-property measurements on model materials and novel material chemistries from quasi-static to dynamic rates. The goal is to foster a materials by design approach for novel energy dissipation and force re-direction mechanisms. Processing-Structure...
Fab Domain from NISTmAb

Metrologies for Protein Structure, Dynamics and Function

Ongoing
Based on its established expertise, infrastructure, and resources for structure/function studies of biological macromolecules, the program aims to impact advances in physics, chemistry, and engineering relevant to biological problems. NIST researchers also develop new technologies for application to...
Illustration showing examples of acidic, neutral and alkaline pH values ranging from 0 to 14 that include battery, stomach acid, lemon, soda, tomato, coffee, milk, water, blood, egg white, stomach tablets, ammonia solution, soap, bleach and drain cleaner.

pH Metrology

Ongoing
The suite of NIST pH SRMs forms the basis for pH measurements in the United States, and pH is the most-often-measured chemical quantity. Hence this NIST work directly or indirectly impacts a large number of users in industry, government, and academia. One of the most critical set of users is in...
Gears illustrating NIST's cell-free systems initiatives

Metrology For Cell-Free Expression Systems

Ongoing
Cell-free expression systems are poised to advance the US bioeconomy and play a key role in ensuring US manufacturing resilience. NIST has several, on-going projects in its growing portfolio to promote reproducibility, new measurement methods, and best practices and standards in cell-free expression...
Photo of the magnetic moment and susceptibility SRMs - platinum cylinder, YIG sphere, Ni sphere, and Ni disk.

Metrology of Magnetic Materials

Ongoing
Currently, the bulk of this project is focused on three main pieces: Thermal MagIC: An SI-Traceable Method for 3D Thermal Magnetic Imaging and Control Magnetic Refrigeration Magnetic Standard Reference Materials (SRMs) Thermal MagIC (MAGnetic Imaging and Control) is focused on developing new...

Metrology for Nanoimprint Lithography

Completed
Nanoimprint Lithography (NIL) was originally perceived as a versatile, low-cost, and high-resolution patterning alternative for optical lithography in CMOS fabrication. However, it is becoming apparent that NIL has great potential for nanotechnology in general. It is capable of patterning sub-10 nm...
CDSAXS instrument

Metrology for Nanolithography

Ongoing
Small Angle Scattering techniques are employed to measure, with sub-nm precision, pattern shape, dimensions, and orientation for structures created in periodic arrays. Critical-Dimension Small Angle X-ray Scattering (CD-SAXS) utilizes the variable-angle transmission scattering from a small beam size...
Nanomaterial-containing Drug Classes graphic

Metrology for Nanomaterials in Medicine

Ongoing
Drug products that incorporate nanomaterials are defined by FDA as non-biological complex drugs (NBCDs). NBCDs are a class of medical products that cannot be defined nor fully identified as traditional small-molecule drugs. NBCDs consist of different components that form a complex hybrid structure...
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