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Search Publications by: Pawel Jaruga (Fed)

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Displaying 101 - 116 of 116

Biomarkers of TP53 Mutation and Y-Chromosome Loss Used to Detect Cellular/Genetic Damage in Tissue Engineered Skin

September 1, 2002
Author(s)
H Rodriguez, M A. Marino, P McAndrew, Donald H. Atha, Pawel Jaruga, M Birincioglu, Peter E. Barker, C D. O'Connell
Tissue engineering is an emerging area of biotechnology that will provide replacement tissues for patients, as well as complex, functional biological systems for research and testing in the pharmaceutical industry. Fundamentals to many tissue-engineered

Free Radical-Induced Damage to DNA: Mechanisms and Measurement

June 1, 2002
Author(s)
M. Dizdaroglu, Pawel Jaruga, M Birincioglu, H Rodriguez
Free radicals are produced in cells by cellular metabolism and by exogenous agents. These species react with biomolecules in cells including DNA. The resulting damage to DNA which is also called oxidative damage to DNA, is implicated in mutagenesis

Identification and Characterization of a Human DNA Glycosylase for Repair of Modified Bases in Oxidatively Damaged DNA

March 19, 2002
Author(s)
T. K. Hazra, T. Izumi, I Boldough, B Imhoff, Y W. Kow, Pawel Jaruga, Miral M. Dizdar, Somenath Mitra
8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species, are often mutagenic and toxic, and have been implicated in the etiology of many diseases including cancer

Chlorella Virus Pyrimidine Dimer Glycosylase Excises Ultraviolet Radiation- and Hydroxyl Radical-Induced Products 4,6-Diamino-5-Formamidopyrimidine and 2,6-Diamino-4-Hydroxy-5-Formamidopyrimidine from DNA

February 1, 2002
Author(s)
Pawel Jaruga, R Jabil, Amanda K. McCullough, H Rodriguez, M Miral Dizdar, R S. Lloyd
A DNA glycosylase specific for UV radiation-induced pyrimidine dimers has been identified from chlorella virus Paramecium bursaria chlorella virus-1. This enzyme (Chlorella virus Pyrimidine dimer glycosylase [cv-pdgl) exhibits a 41% amino acid identity

Determination of Active Site Residues in Escherichia Coli Endonuclease VIII

January 25, 2002
Author(s)
S. M. Burgess, Pawel Jaruga, M L. Dodson, Miral M. Dizdar, R S. Lloyd
Endonuclease VIII from Escherichia coli is a DNA glycosylase/lyase that removes oxidatively damaged bases. EndoVIII is a functional homologue of endonuclease III, but a sequence homologue of formamidopyrimidine DNA glycosylase (Fpg). Using multiple

The Cockayne Syndrome Group B Gene Product is Involved in General Genome Base Excision Repair of 8-hydroxyguanine in DNA

December 7, 2001
Author(s)
J Tuo, M Muftuoglu, C Chen, Pawel Jaruga, R R. Selzer, R M. Brosh, H Rodriguez, Miral M. Dizdar, V. Bohr
Cockayne Syndrome (CS) is a human genetic disorder with two complementation groups, CS-A and CS-B. The CSB gene product is involved in transcription-coupled repair of DNA damage but may participate in other pathways of DNA metabolism. The present study

Mechanisms and Measurement of Oxidative Damage to DNA

March 1, 2001
Author(s)
M. Dizdaroglu, Pawel Jaruga, H Rodriguez
Free radicals are produced in cells by normal metabolism and by exogenous sources. These species cause oxidative damage to DNA and generate multiple products including modified bases and sugars, strands breaks and DNA-protein crosslinks by a variety of
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