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Displaying 13126 - 13150 of 74178

Self-contained, Low Cost “Body-on-a-Chip” Systems for Drug Development

February 17, 2017
Author(s)
Ying Wang, Oleaga Carlota, Long Christopher, McAleer Christopher, Paula Miller, James J. Hickman, Michael L. Shuler, Mandy B. Esch
Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as “Body-on-a-Chip” devices, have a great potential to increase the

Ultrafast time-resolved x-ray absorption spectroscopy of ferrioxalate photolysis with a laser plasma x-ray source and microcalorimeter array

February 17, 2017
Author(s)
Galen C. O'Neil, Joel N. Ullom, Luis Miaja Avila, Young Il Joe, Joseph W. Fowler, Carl D. Reintsema, Daniel S. Swetz, Kevin L. Silverman, Daniel R. Schmidt, Bruce D. Ravel, Gene C. Hilton, William B. Doriese, Bradley K. Alpert, Ralph Jimenez
Using a table-top apparatus based upon a laser plasma x-ray source and an array of cryogenic microcalorimeter x-ray detectors, we have measured the transient x-ray absorption spectrum during the ferrioxalate photoreduction reaction. We observe the Fe K

Uniaxial Pressure Effect on the Magnetic Ordered Moment and Transition Temperatures in BaFe 2-x T x As 2 (T=Co,Ni)

February 17, 2017
Author(s)
David W. Tam, Yu Song, Haoran Man, Sky C. Cheung, Zhiping Yin, Xingye Lu, Weiyi Wang, Benjamin A. Frandsen, Lian Liu, Zizhou Gong, Takashi U. Ito, Yipeng Cai, Murray N. Wilson, Shengli Guo, Keisuke Koshiishi, Wei Tian, Bassam Hitti, Alexandre Ivanov, Yang Zhao, Jeffrey W. Lynn, Graeme M. Luke, Tom Berlijn, Thomas A. Maier, Yasutomo J. Uemura, Pengcheng Dai
We use neutron diffraction and muon spin relaxation to study the effect of uniaxial pressure on the paramagnetic-to-antiferromagnetic phase transition (T N) in BaFe 2As 2 and superconducting BaFe 1.915Ni 0.085As 2. In a local moment picture, the uniaxial

Email Authentication Mechanisms: DMARC, SPF and DKIM

February 16, 2017
Author(s)
J. S. Nightingale
In recent years the IETF has been making a range of efforts to secure the email infrastructure and its use. Infrastructure protection includes source authentication by RFC 7208 Sender Policy Framework (SPF), message integrity authentication by RFC 6376

Repair of Oxidatively Induced DNA Damage by DNA Glycosylases

February 16, 2017
Author(s)
M Miral Dizdar, Erdem Coskun, Pawel Jaruga
Endogenous and exogenous reactive species cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. As a result, a plethora of mutagenic and/or cytotoxic products are formed in cellular DNA. This type of DNA damage is repaired by

The factor of 10 in forensic DNA match probabilities

February 16, 2017
Author(s)
Simone N. Gittelson, Tamyra R. Moretti, Anthony J. Onorato, Bruce Budowle, Bruce S. Weir, John Buckleton
An update was performed of the classic experiments that led to the view that profile probability estimates are usually within a factor of 10 of each other. The data used in this study consist of 15 Identifiler loci collected from forensic publications of a

Unified scaling law for flux pinning in practical superconductors: Part 3. Extrapolations from minimum datasets and applications of the extrapolative scaling expression

February 16, 2017
Author(s)
John (Jack) W. Ekin, Najib Cheggour, Loren F. Goodrich, Jolene D. Splett
The accuracy of present fitting equations to interpolate and extrapolate full Ic(B,T,ε) datasets is evaluated and compared with the extrapolative scaling expression (ESE) derived in Part 2. Accuracy is analyzed in terms of RMS error and fractional

LTE impacts on GPS

February 15, 2017
Author(s)
William F. Young, Ari D. Feldman, Sheryl M. Genco, Azizollah Kord, Daniel G. Kuester, John M. Ladbury, Duncan A. McGillivray, Audrey K. Puls, Andre R. Rosete, Adam J. Wunderlich, Wen-Bin Yang
This report describes the test methodology from “LTE impacts on GPS: Test and Metrology Plan” developed by National Advanced Spectrum and Communications Test Network (NASCTN), and data that are the result of executing the test method. The fundamental goals

Variable Threshold Method for Determining the Boundaries of Imaged Subvisible Particles

February 15, 2017
Author(s)
Richard E. Cavicchi, Cayla Collett, Srivalli Telikepalli, Zhishang Hu, Michael J. Carrier, Dean C. Ripple
An accurate assessment of particle characteristics and concentrations in pharmaceutical products by flow imaging requires accurate particle sizing and morphological analysis. Analysis of images begins with the definition of particle boundaries from the

Noise characteristics of thermistors: measurement methods and results of selected devices

February 13, 2017
Author(s)
Ivan Ryger, Michelle S. Stephens, Malcolm G. White, Nathan A. Tomlin, Matthew T. Spidell, John H. Lehman, Dave Harber
As part of the development of a spectrally-uniform room-temperature absolute radiometer, we have studied the electrical noise of several bulk chip thermistors in order to estimate the noise floor and optical dynamic range. Understanding the fundamental

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

February 11, 2017
Author(s)
Natalia Mast, Kyle Anderson, Joseph Lin, Yong Li, Illarion Turko, Curtis Tatsuoka, Ingemar Bjorkhem, Irina A. Pikuleva
Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereo-specific hydroxylation of different sterols. In humans, complete CYP27A1 deficiency leads to cerebrotendinous xanthomatosis or

A new approach to quantification of mAb aggregates using peptide affinity probes

February 10, 2017
Author(s)
Crystal Cheung, Kyle Anderson, Pooja Patel, Keale Cade, Karen W. Phinney, Illarion Turko
Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to a variety of adverse events in treatment. Here, we describe a proof-of-concept for new methodology to detect and

Adaptive Multi-scale Prognostics and Health Management for Smart Manufacturing Systems

February 10, 2017
Author(s)
Benjamin Y. Choo, Brian Weiss, Jeremy Marvel, Stephen C. Adams, Peter A. Beling
Adaptive Multi-scale Prognostics and Health Management (AM-PHM) is a methodology designed to enable PHM in smart manufacturing systems. As a rule, PHM information is not yet fully utilized in higher-level decision-making in manufacturing systems. AM-PHM

Open Source Private Cloud Platforms for Big Data

February 10, 2017
Author(s)
Martial Michel, Edmond J. Golden III, Olivier Serres, Ahmad Anbar, Tarek El-Ghazawi
Due to its availability, Cloud computing is the de facto platform of choice for big data, where Big Data as a Service (BDaaS) is believed to be the next best thing. In this book chapter we will first introduce cloud computing, defining the advantages it
Displaying 13126 - 13150 of 74178