Wang, Y.
, Carlota, O.
, Christopher, L.
, Christopher, M.
, Miller, P.
, Hickman, J.
, Shuler, M.
and Esch, M.
(2017),
Self-contained, Low Cost “Body-on-a-Chip” Systems for Drug Development, Experimental Biology and Medicine, [online], https://doi.org/10.1177/1535370217694101
(Accessed April 25, 2024)
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Self-contained, Low Cost Body-on-a-Chip Systems for Drug Development
Published
Author(s)
Ying Wang, Oleaga Carlota, Long Christopher, McAleer Christopher, Paula Miller, James J. Hickman, Michael L. Shuler,
Abstract
Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as Body-on-a-Chip devices, have a great potential to increase the successful conversion of drug candidates into approved drugs. Systems, to be attractive for commercial adoption, need to be low cost, easy to operate, and give reproducible results. Further, the ability to measure functional responses, such as electrical activity and force generation by organ surrogates, enhances the ability to monitor response to drugs. The ability to operate a system for significant periods (up to 28 days) will provide potential to estimate chronic as well as acute responses. Here we review progress towards a low cost microphysiological system with functional measurements of physiological response.Citation
Experimental Biology and Medicine
Pub Type
Journals
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Citation
Created February 17, 2017, Updated November 10, 2018