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Self-contained, Low Cost “Body-on-a-Chip” Systems for Drug Development

Published

Author(s)

Ying Wang, Oleaga Carlota, Long Christopher, McAleer Christopher, Paula Miller, James J. Hickman, Michael L. Shuler, Mandy B. Esch

Abstract

Integrated multi-organ microphysiological systems are an evolving tool for preclinical evaluation of the potential toxicity and efficacy of drug candidates. Such systems, also known as “Body-on-a-Chip” devices, have a great potential to increase the successful conversion of drug candidates into approved drugs. Systems, to be attractive for commercial adoption, need to be low cost, easy to operate, and give reproducible results. Further, the ability to measure functional responses, such as electrical activity and force generation by organ surrogates, enhances the ability to monitor response to drugs. The ability to operate a system for significant periods (up to 28 days) will provide potential to estimate chronic as well as acute responses. Here we review progress towards a low cost microphysiological system with functional measurements of physiological response.
Citation
Experimental Biology and Medicine

Citation

Wang, Y. , Carlota, O. , Christopher, L. , Christopher, M. , Miller, P. , Hickman, J. , Shuler, M. and Esch, M. (2017), Self-contained, Low Cost “Body-on-a-Chip” Systems for Drug Development, Experimental Biology and Medicine, [online], https://doi.org/10.1177/1535370217694101 (Accessed July 23, 2024)

Issues

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Created February 17, 2017, Updated November 10, 2018