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Chemistry

Analytical chemistry

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Displaying 501 - 525 of 2084

Determination of the molar mass of argon from a high precision acoustic comparison

May 18, 2017
Author(s)
XiaoJuan Feng, Jintao Zhang, Michael R. Moldover, Inseok Yang, Mark Plimmer, H. Lin
This article describes the accurate determination of the molar mass of a sample of argon gas used for a determination of the Boltzmann constant. The method due to one of the authors [Moldover et al., J. Res. Natl. Bur. Stand. 93, 85-144 (1988)] uses the

Conformational Changes in Active and Inactive States of Human PP2C? characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry

May 8, 2017
Author(s)
Sharlyn Mazur, Elyssia S. Gallagher, Subrata Debnath, Stewart R. Durell, Kyle Anderson, Lisa M. Jenkins, Ettore Appella, Jeffrey W. Hudgens
PPM serine/threonine protein phosphatases function in signaling pathways and require millimolar concentrations of Mn2+ or Mg2+ ions for activity. Whereas the crystal structure of human PP2Cα displayed two tightly bound Mn2+ ions in the active site, recent

DART-MS analysis of inorganic explosives using high temperature thermal desorption

May 4, 2017
Author(s)
Thomas P. Forbes, Edward R. Sisco, Matthew E. Staymates, John G. Gillen
An ambient mass spectrometry (AMS) platform coupling Joule heating thermal desorption (JHTD) and direct analysis in real time (DART) was developed, generating discretely pulsed rapid heating ramps and elevated temperatures for the detection of inorganic

CH3NH3PbI3 perovskites: Ferroelasticity revealed

April 14, 2017
Author(s)
Evgheni Strelcov, Qingfeng Dong, Tao Li, Jungseok Chae, Yuchuan Shao, Yehao Deng, Alexei Gruveman, Jinsong Huang, Andrea Centrone
Ferrolectricity has been proposed as a plausible meachanism to explain the high photovoltaic conversion efficiency in organic-inorganic perovskites; however, convincing experimental evidence in support to this hypothesis is still missing. Identifying and

The Hybrid Search: A Mass Spectral Library Search Method for Discovery of Modifications in Proteomics

April 3, 2017
Author(s)
Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Stephen E. Stein, Jenny Heidbrink Thompson, Christopher Larkin
We present a mass spectral library based method to identify tandem mass spectra of peptides that contain unanticipated modifications and amino acid variants. We describe this as a ‘hybrid’ method since it combines matching both ion m/z and mass losses. The

Mass Spectral Library Quality Assurance by Inter-Library Comparison

April 2, 2017
Author(s)
William E. Wallace, Weihua Ji, Dmitrii V. Tchekhovskoi, Karen W. Phinney, Stephen E. Stein
A method to discover and correct errors in mass spectral libraries is described. Comparing across a set of highly curated reference libraries compounds that have the same chemical structure quickly identifies entries that are outliers. In cases where three

Quantifying Stability of Trace Explosives under Different Environmental Conditions

April 1, 2017
Author(s)
Edward R. Sisco, Marcela N. Najarro, Daniel V. Samarov, Jeffrey A. Lawrence
This work investigates the stability of trace deposits of six explosives (ETN, PETN, RDX, HMX, TNT, and Tetryl) to determine environmental stabilities and lifetimes. Explosives were inkjet printed directly onto PTFE coated fiberglass substrates and exposed

Liquid Chromatography Column Theory and Technology

March 8, 2017
Author(s)
Lane C. Sander
Column selection is probably the single most important aspect of method development that will directly affect measurement accuracy and precision of liquid chromatographic (LC) measurements. An understanding of physical and chemical properties of LC columns

Liquid Chromatography: Introduction to Method Development

March 8, 2017
Author(s)
Lane C. Sander
The development of fit-for-purpose analytical methods is an essential component of chemical metrology. This presentation will provide guidance on approaches for establishing robust analytical methods, particularly with applications to liquid chromatography

Solid Phase Extraction

March 8, 2017
Author(s)
Lane C. Sander
Solid Phase Extraction [video, running time 29 minutes 2 seconds] \\europa\839.02\training\Solid Phase Extraction (29.02 minutes).mp4 Lane C. Sander Chemical Sciences Division Material Measurement Laboratory National Institute of Standards and Technology

Expanding lipidome coverage using LC-MS/MS data-dependent acquisition with automated exclusion list generation

March 6, 2017
Author(s)
John Bowden, Jeremy P. Koelmel, Nicholas M. Kroeger, Emily L. Gill, Candice Z. Ulmer, Rainey E. Patterson, Richard A. Yost, Timothy J. Garrett
Untargeted omics analyses aim to comprehensively characterize biomolecules within a biological system. Changes in the presence or quantity of these biomolecules can indicate important biological perturbations, such as those caused by disease. With current

Characterization of a PXIe based low-field digital NMR spectrometer

February 25, 2017
Author(s)
Joshua R. Biller, Karl F. Stupic, Anthony B. Kos, Timothy Weilert, George Rinard, Yoshi Nakashima, John M. Moreland
A low-field nuclear magnetic resonance (NMR) instrument is an important tool for investigating a wide variety of samples under different conditions. In this paper, we describe a system constructed primarily with commercially available hardware and control

Measurements of translation initiation from all 64 codons in E. coli

February 21, 2017
Author(s)
Ariel H. Hecht, Jeff E. Glasgow, Paul Jaschke, Lukmaan Bawazer, Matthew S. Munson, Jennifer R. Cochran, Drew Endy, Marc L. Salit
Our understanding of translation represents a cornerstone of molecular biology and underpins our capacity to engineer living matter. For decades, the codon AUG and a few near-cognates (GUG, UUG) have been exclusively considered as “start codons” for
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