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M. L. De Leoz, David L. Duewer, Scientists Multiple, Stephen E. Stein
Glycosylation is a topic of intense current interest in the development of biologic drugs since it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of NISTmAb, a monoclonal antibody
Katrice Lippa, David L. Duewer, Michael Nelson, Stephen Davies, Lindsey Mackay
Metrological traceability for organic measurements is a documented unbroken chain of calibrations with stated uncertainties that link the chemical result for a sample and a measurement procedure to a primary calibrator in appropriate SI units (e.g., mass
Mary Kombolias, Jan Obrzut, Michael T. Postek, Dianne L. Poster, Yaw S. Obeng
The current analytical techniques for characterizing printing and graphic arts substrates are largely ex situ and destructive. This limits the amount of data that can be obtained from an individual sample and renders it difficult to produce statistically
In the context of chemical metrology, calibration is the process of relating a known quantity of an analyte to the corresponding measured instrumental response through a mathematical relationship. Calibration permits the assignment of analyte levels in
Thomas Forbes, Jeffrey Lawrence, Jennifer R. Verkouteren, R. Michael Verkouteren
The opioid crisis and emergence of fentanyl, fentanyl analogues, and other synthetic opioids has highlighted the need for sensitive and robust detection for interdiction at screening points, notably vehicles at border crossings and packages at postal
The current opioid epidemic remains an ongoing challenge, exacerbated by the extreme potency of synthetic opioids (e.g., fentanyl and fentanyl analogues), leading to an increase in adulterated heroin-related deaths. The increasing prevalence of fentanyl
Zeeshan Ahmed, Nathan J. Castro, Matthew R. Hartings
Although the determination of pH is a standard laboratory measurement, new techniques capable of measuring pH are being developed to facilitate modern technological advances. Bio-industrial processing, tissue engineering, and intracellular environments
Screening technologies are necessary to counteract illegal trafficking of drugs and people through ports of entry in the United States and internationally. Here we present results from initial field testing of a recently-developed portable vapor sensing
Adam Kurtz, Jessica L. Reiner, Kristi West, Brenda Jensen
Perfluorinated alkyl acids (PFAAs) are persistent in marine biota and are toxic to many species, including marine mammals. We measured the concentrations of 15 PFAAs in liver and kidney samples of 16 species of stranded cetaceans from Hawai‘i and other
Arthur S. Edison, Adrien Le Guennec, Frank Delaglio, Eriks Kupce
We present an overview of 13C-based NMR metabolomics. At first glance, the low sensitivity of 13C relative to 1H NMR might seem like too great an obstacle to use this approach. However, there are several advantages to 13C NMR, whether samples can be
Chemometric analysis of comprehensive two-dimensional chromatography coupled to time-of-flight mass spectrometry data has been reported with various workflows. The report presented herein aims to investigate the effects of different pre-processing and
Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri A. Mirokhin, Stephen E. Stein
A large fraction of ions observed in electrospray liquid chromatography-mass spectrometry (LC-MS) experiments of biological samples remain unidentified. One the main reasons for this is that spectral libraries of pure compounds fail to account for the
Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri Mirokhin, Stephen E. Stein
A large fraction of ions observed in electrospray liquid chromatography–mass spectrometry (LC–ESI-MS) experiments of biological samples remain unidentified. One of the main reasons for this is that spectral libraries of pure compounds fail to account for