Sander, L.
(2017),
Solid Phase Extraction, Journal of Research (NIST JRES), National Institute of Standards and Technology, Gaithersburg, MD, [online], https://doi.org/10.6028/jres.122.019 (Accessed April 26, 2026)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Solid Phase Extraction
Published
Author(s)
Abstract
Solid Phase Extraction [video, running time 29 minutes 2 seconds] \\europa\839.02\training\Solid Phase Extraction (29.02 minutes).mp4 Lane C. Sander Chemical Sciences Division Material Measurement Laboratory National Institute of Standards and Technology Gaithersburg, MD 20899 Solid phase extraction is a form of liquid chromatography used in processing samples to selectively isolate constituents of interest from other compounds that may interfere with the analysis. Before a solid sample can be processed by SPE, it must first be extracted by soxhlet extraction, pressurized fluid extraction, or other method, to produce a solution that contains the analytes. SPE methods usually target the analytes through selective retention mechanisms that are different from the instrumental method. The resulting processed samples are simpler than the original extracts, and may result in improved analytical results. This presentation will provide an overview of the theory and practice of solid phase extraction, and will include a demonstration of the use of different types of SPE devices.Citation
Journal of Research (NIST JRES) -
Volume
122
NIST Pub Series
Pub Type
NIST Pubs
Download Paper
Keywords
solid phase extraction, SPE, cleanup, fractionation, analytical methods
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact [email protected].
Created March 8, 2017, Updated January 27, 2020