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Projects/Programs

Keyword

Organizational Unit

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms

Ongoing

Intended impact Ionizing radiation-resistant microorganisms have recently garnered a great deal of attention from scientists seeking to understand the mechanisms underlying the survival abilities of these organisms. Much of the focus has been on mechanisms of cellular repair of radiation-induced DNA

Protein Preservation

Ongoing

This project is an integral part of a cooperative effort – led by NIST, and partially funded by NIH/ NIBIB – which includes the University of Wisconsin, the University of Colorado, and the University of Connecticut. We use the following approach to develop measurement solutions for biopharmaceutical

Protein rheology measurements

Ongoing

Intended Impact Why does the health-care industry care about rheology and scattering of protein solutions? Operations. Viscosity is a critical and fundamental constitutive input for drug delivery, device design and manufacturing. For example, high viscosity leads to poor syringeability due to

Protocol for Preparing Fibrillar Collagen Matrices on Untreated Polystyrene Labware (Petri)*: A Potential Reference Extracellular Matrix With Robust and Reproducible Cell Responses

Ongoing

Preparation of matrices on a polystyrene surface 1.) Remove DPBS (1x), DPBS (10x), 0.1 M sodium hydroxide, collagen stock from 4 °C storage. 2.) Setup workspace in sterile hood with an appropriate workflow (example shown in Figure 1). 3.) Prepare Collagen Solution. Note: either mix this quickly, or

Protocols, datasets, and software for engineering biology

Ongoing

Published protocols, datasets, and software for engineering biology from the Cellular Engineering Group. Protocols Romantseva J, Ross D, Alperovich A, Strychalski E, Automated DNA template preparation and quantitation methods, https://www.protocols.io, March 23, 2022, https://dx.doi.org/10.17504

Prototype Cell Assay Measurement Platform (P-CAMP)

Ongoing

A systematic approach to the development of robust biological assay includes identifying and ranking the sources of variability in an assay protocol. With a focus on mammalian cellular assays, the Prototype Cell Assay Measurement Platform ( P-CAMP) laboratory was designed and built to take advantage

Picture of prototype ultrasonic wearable device for proximity detection

Proximity Detection for Electronic Contact Tracing

Completed

We are developing performance metrics for not just ranging, but also for detecting close contacts, which in the context of COVID-19 is the situation where two people are less than six feet apart with no obstacles between them. Obviously, the duration of a close contact is important, as it affects

Public Health Risks to First Responders

Ongoing

OBJECTIVE: To identify a firefighter’s relative risk of exposure to per- and polyfluoroalkyl substances (PFAS) released from their protective gear. TECHNICAL IDEA: The new technical idea is to determine the type, root source, and release mechanism of PFAS from FFG, which could be used to restrict

Public Safety 700-MHz Broadband Deployable Systems

Ongoing

The Middle Class Tax Relief and Job Creation Act of 2012 (H.R. 3630) appropriated $7 billion for the establishment of a nationwide interoperable public safety broadband network (PSBN) under FirstNet, an independent authority in the National Telecommunications and Information Administration (NTIA)

Public Safety 700-MHz Broadband Modeling and Simulation

Ongoing

Public Safety Audio Quality

Ongoing

The audio codec (also called speech codec, voice coder, or vocoder) is a key hardware/software component in every digital radio or handset. At a transmitting location, the codec processes incoming audio into a concise digital representation for efficient transmission over the air. At the receiving

Public Safety Broadband Cybersecurity

Ongoing

Along with the implementation of a nationwide public safety broadband network based on Long Term Evolution (LTE) technology, the network’s cybersecurity capabilities and features will be unique compared to traditional commercial mobile carriers due to public safety’s operational environment and

Public Safety Broadband Requirements and Standards Project Description

Ongoing

PSCR has actively participated in the requirements gathering and standards development process for public safety communications since its inception in 2007. "The PSCR (Public Safety Communications Research) staff ... has traveled the world over, going to 3GPP meetings and going from a point where we

Public Safety Communications Program

Ongoing

America’s first responders deal with emergencies every day. And whether it is a routine traffic stop, a multi-alarm fire, or a large-scale event, such as Hurricanes Harvey and Sandy, or the attacks on 9/11, the ability of first responders to communicate with each other--on-scene as well as through

Public Safety Communications Research

Ongoing

Too often in critical situations communications the data exchanges between law enforcement and public safety agencies are hampered by equipment incompatibilities. In large part these incompatibilities are due to a lack of standards to provide a common, nationwide approach to telecommunications and

Public Safety Image Quality

Ongoing

Here is our plan in a nutshell: Ask how first responders how their department uses photos and video Collect images that demonstrate the many ways first responders use photography Identify patterns—image and video quality problems that impact many first responders Stimulate innovation on novel camera

Public Safety Mobile Application Security

Ongoing

The nationwide public safety broadband network will provide first responders with modern access to data. This new access to multimedia (audio/video), situational awareness data, and operations functionality will enhance first responder’s effectiveness and efficiency. While mobile applications can

Publishing Services

Ongoing

The NIST Research Library occupies the unique position of serving NIST both as publisher of the NIST Technical Series, and in an archival capacity, responsible for collecting and preserving copies of NIST's grey literature. Over the last 15 years, the Library's publishing services have evolved from

Pushing the Limits of Measurement Accuracy in Atom Probe Mass Spectrometry

Ongoing

Isotopic Analysis for Isotopic Geochemistry, Nuclear Safety, and Materials Science : Atom probe tomography has a significant advantage over other forms of mass spectrometry, which typically have a combined efficiency < 5%, in terms of ionization and detection efficiency. Commercial atom probe

Qualification for Additive Manufacturing Materials, Processes, and Parts

Completed

Objective: Develop test methods and protocols, provide reference data, and establish requirements to reduce the cost and time to qualify AM materials, processes, and parts. Technical Idea: Qualification of AM materials, processes, and parts is critical to enabling the AM industry to crack into the

Qualification for AM Feedstocks, Machines and Processes

Completed

Objective - To develop, utilize, and analyze test methods and protocols for characterizing the feedstocks, machines, and processes in metal-based additive manufacturing to enable optimum usage and to reduce the cost and time needed for qualification. What is the Technical Idea? Qualification of AM

Quality Assessment of Cryogenic Electron Microscopy Images

Ongoing

Manufacturing a vaccine based on packaging mRNA in lipid nanoparticles requires a full characterization of concentrations and distributions of mRNA and LNPs, as well as all manufacturing conditions. Such experiments generate hundreds of terabytes (TBs) of images and pose challenges on trusted

Quantification of Cells with Specific Phenotypic Characteristics

Ongoing

Internationally recognized and validated reference standards are currently not available in the field of cellular phenotyping by flow cytometry. The World Health Organization (WHO) has issued an open letter to the manufacturers of CD4 + T-cell enumeration technologies for the HIV/AIDS epidemic

Quantification and Characterization of Plastic Additives

Ongoing

Plastic products are not “pure polymers'' as they consist of up to 70 % additive chemicals by weight. Plastic additives are mixed into the polymer matrix during production to enhance functional properties, performance, or appearance of the plastic product. The use of additives in plastics is

Quantification of Material, Loading, and Modeling Uncertainties of Reinforced Concrete Column Components and Frame Systems under Seismic and Gravity Loads for Use in PBSE

Completed

Objective - To quantify the influences of uncertainties in material properties, loads, and modeling techniques on the performance of reinforced concrete column components and frame systems under lateral seismic and axial loads from gravity. The results of this study will be integrated with the

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Advanced communications
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Bioscience
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Forensic Science
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Health
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Information technology
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