Projects/Programs

Displaying 1 - 25 of 42

Augmented Intelligence for Manufacturing Systems (AIMS)

Ongoing

Objective To overcome existing measurement challenges via augmented intelligence, the fusion of integrated metrology, physics-based models, and artificial intelligence, to enable monitoring, diagnostics, and prognostics of manufacturing systems and their processes. Technical Idea One research

Basic Metrology (Archive): New Standardization of Ra-228

Completed

Radium-228 has a half-life of (5.75 years) and decays by emitting a beta particle. It is a radioactive decay product in the thorium-232 decay series, a very difficult and complex decay chain: 232Th→ 228Ra → 228Ac → 228Th → 224Ra → 220Rn → 216Po → 212Pb → 212Bi → 208Tl → 208Pb(stable); with a sub

photon attenuation cross section measurements

Basic Metrology: Standard Reference Data on Radiation Interactions

Ongoing

This work continues in the Division's Photon and Charged-Particle Data Center. The compilations of the Data Center rely heavily on evaluating measurements and on their synthesis with available theory to extend the data and provide for comprehensive coverage over broad ranges of energy and materials

Biomanufacturing Initiative

Ongoing

The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

Calibration Service: Air-Kerma Calibrations in Radiation Protection Level Cs-137 and Co-60 Gamma Ray Beams

Ongoing

The national standard for air kerma is disseminated throughout the U.S. by way of a network of secondary calibration facilities that in turn calibrate radiation detection instruments such as ionization chambers, survey meters, electronic personal dosimeters (EPDs), thermoluminescent dosimeters (TLDs

Carbon Capture, Use, and Storage

Ongoing

Carbon Capture, Use, and Storage (CCUS) requires a suite of technologies to capture carbon dioxide from industrial point sources, the atmosphere, and the ocean; convert carbon dioxide into products such as fuels, chemical feedstocks, and building materials; and sequester carbon dioxide deep

Computational Chemistry

Ongoing

Given the combinatorial possibilities for combining fundamental elements to create novel molecules, bench science experimentation is impractical as a wholesale means to discovery. By contrast, computational resources abound and thereby offer a possible alternative. However, this immense resource is

Crystallographic Databases

Ongoing

Impact and Customers Materials with new or improved properties are continually being developed to meet demands for increased functionality of components and devices at decreased costs. Examples of multi-million dollar industries driven by materials advances are solid-state lighting (GaN-based

Figure contains text “Omics Data Quality” and human outline with arrows pointing from the human to the following specimen types: liver, serum, stool, plasma, urine. On either side of the human are analytical spectra and everything is surrounded by a decorative molecule structure circular border.

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

There is a significant need for tools to increase harmonization, comparability, and reproducibility between laboratories and/or studies, and to provide quality control of sample preparation and data analysis protocols utilized in untargeted omics analysis. Reference materials are being developed to

Picture of PBD set up for wavelength measurement

Diffraction Metrology and Standards

Ongoing

Diffraction techniques can provide data on a number of sample characteristics. Therefore, the method of certification and the artifact itself are chosen to address a specific measurement issue pertinent to a diffraction experiment. NIST diffraction SRMs may be divided into five groups: Line Position

Digital PCR

Ongoing

With appropriately validated assays, digital polymerase chain reaction (dPCR) determines the number of DNA targets (copies) per reaction partition, without the need for a standard curve. Reaction partitions can be in the form of fixed chambers in a microfluidic device, referred to as chamber digital

Effect of Partial Charge Calculation Method on Adsorption Thermodynamics in Metal-organic Frameworks

Ongoing

Electrostatic interactions are an important contribution to the interatomic or intermolecular potential energy in any system, whether homogeneous (bulk phase) or heterogeneous (fluid and confining material or multiple fluid phases). This is particularly true for heterogeneous systems in which the

Electrical performance measurements and calibrations for photovoltaic cells and arrays

Ongoing

Objective To develop or improve the electrical and optical measurement science of photovoltaic cells to: (1) continue offering a calibration service to allow industry and academia to accurately assess device performance under a range of operating conditions, (2) offer a new measurement service for

Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database

Ongoing

Intended Impact The speed and accuracy of chemical analyses are vital issues in many areas. Monitoring for explosives, drugs (both legal and illegal), chemical weapons, pollutants, petrochemical processing, food contamination, and health/disease status biomarkers is a challenge with a high reward in

e-Statistics

Ongoing

Coming soon.

External RNA Controls Consortium

Completed

While early gene expression measurements with DNA microarrays were groundbreaking in their ability to reveal biological activity, the results were irreconcilable and irreproducible. Industry leaders approached the National Institute of Standards and Technology (NIST) in 2003 for help with addressing

FAQs - Genome in a Bottle

Ongoing

Gas properties for flow metering

Ongoing

NIST has two on-line databases that include accurate gas viscosity values: SEMIPROP - NIST Standard Reference Database 134 - for selected semiconductor process gases NIST Chemistry WebBook - for heat transfer fluids, components of air, components of natural gas [Note: as of February 2014, the NIST

Genome in a Bottle

Ongoing

Consortium goals: The Genome in a Bottle Consortium is a public-private-academic consortium hosted by NIST to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of whole human genome sequencing to clinical practice and innovations

Inorganic Phase Equilibrium Data

Ongoing

Every deliberate effort to develop a new material or to improve processing begins with chemical composition and the conditions (temperature, pressure) under which pure compounds and their mixtures are stable ( an equilibrium phase diagram ). In the absence of such information, materials scientists

Material Qualification

Ongoing

Objective To develop, utilize, and analyze methods of characterizing the precursor materials in additive manufacturing in both virgin and recycled states with the goal of advancing measurement science to benefit the AM community. The components of principal interest will include the rheological

Wordcloud figure with about 25 words including NIST, metabolomics, quality assurance, and measurements.

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Ongoing

Metabolomics, a rapidly growing field of systems biology, is expanding beyond human health and precision medicine to encompass areas such as food science, biomanufacturing, and forensic investigation. Analytical techniques include both targeted identification and quantification of metabolites and

Direct Analysis in Real Time Mass Spectrometry infogram

Methods, Software Tools, and Resources for Forensics Laboratories with DART-MS or other AI-MS Techniques

Ongoing

The development of methods, software tools, and resources for forensic laboratories using DART-MS or other AI-MS techniques is a collaborative effort between the Surface and Trace Chemical Analysis Group (STCAG), the Mass Spectrometry Data Center (MSDC), and practicing forensic laboratories across

Metrology for Multi-Physics AM Model Validation

Completed

Objective To provide reference data for the validation of multi-physics models of metal additive manufacturing processes to enable improvement of AM process models and more rapid and predictable process development for AM production by manufacturers. What is the Technical Idea? The Metrology for

The NIST Chemistry Webbook

Ongoing

Intended Impact It is part of NIST's mission to distribute Standard Reference Data to scientists, engineers, educators, and the general public. The NIST Chemistry WebBook is intended to help fulfill NIST's mission by distributing such data over the Internet. Objective Develop a web site

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