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Standards

Projects/Programs

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Living Yeast Cell Reference Material (RM 8230)

Ongoing

Quantification of total and viable microbial cells is critical for applications ranging from assessment of DNA extraction efficiency in support of microbial metagenomics to characterization of antimicrobial efficacy. In addition, safe biological materials are needed to substitute for true biothreat

Cryogenic electron microscopy (cryo-EM) image of an LNP/RNA formulation

LNP-RNA Research Grade Test Material

Ongoing

The currently planned LNP/RNA material (designated RGTM 10240) will include a fragment of the SARS-CoV-2 genome that is approximately 4 kb in length. This fragment was previously included (in unencapsulated form) as “Fragment 1” of NIST RGTM 10169. The RNA fragment is not designed for cell-based

AM Machine and Process Control Methods for Additive Manufacturing

Completed

Objective Develop algorithms, methods and standard protocols for Additive Manufacturing (AM) process control, and implement it with software and hardware tools for open control of AM systems to enable more flexible process optimization by manufacturers. What is the Technical Idea? Additively

Material Qualification

Ongoing

Objective To develop, utilize, and analyze methods of characterizing the precursor materials in additive manufacturing in both virgin and recycled states with the goal of advancing measurement science to benefit the AM community. The components of principal interest will include the rheological

Materials and Systems for Protection Against Penetrating and Blunt Force Phenomena

Ongoing

Injury risks can be reduced by ensuring that protective equipment is well suited for the operational environment. Often, achievement of this goal relies on research to understand the operational environment, the underlying physics that govern the response of materials and equipment, and the

Testing a multi-specimen chain in fatigue in pressurized hydrogen

Materials Testing in Hydrogen Gas

Ongoing

Hydrogen is known to have a deleterious effect on steels and other metals, but steels are the most cost-effective and commonly used materials for pipelines and pressure vessels. We are collaborating with the code bodies (ASME B31.12 and ISO 11114-4), DOT, and DOE, to enable the implementation of

Measurements and Standards for Botanical Dietary Supplements

Ongoing

Many consumers believe that botanical dietary supplements will improve their health and that these "natural" remedies are both effective and free from the side effects that may occur with other medications. There are occasional reports of inaccurate labeling, adulteration, contamination (with

Photograph showing labeled units of SRM 1649 Urban Dust and SRM 1649a Urban Dust.

Measurements and Standards for Contaminants in Environmental Samples

Ongoing

In 1971 NIST issued the first natural environmental matrix SRM for contaminants, SRM 1571 Orchard Leaves, with certified concentrations for trace elements. The development of SRM 1571 Orchard Leaves formalized the approach of combining results from "two or more independent and reliable analytical

Measurements and Standards to Support Nutrition Labeling

Ongoing

Well-characterized certified reference materials are needed by laboratories in the food testing and nutrition communities to facilitate compliance with labeling laws and improve the accuracy of information provided on product labels so that consumers can make good choices. As a result of the

Measuring Cell Viability in Scaffolds

Ongoing

Project Goals Primary Goal: Advance measurements of cell viability in manufactured tissues Establish working group of industry stakeholders to guide work Develop model scaffold-cell-assay system for measuring cell viability in scaffolds Validate measurement system by orthogonal test methods Assess

Medical: Standards for Clinical Radionuclide Calibrators

Ongoing

In nuclear medicine, clinical activity measurements are typically made using commercially available radionuclide calibrators (also referred to as “dose calibrators”) which incorporate a reentrant 4π ionization chamber and an electrometer. The current measured by these calibrators is translated into

Wordcloud figure with about 25 words including NIST, metabolomics, quality assurance, and measurements.

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Ongoing

Metabolomics, a rapidly growing field of systems biology, is expanding beyond human health and precision medicine to encompass areas such as food science, biomanufacturing, and forensic investigation. Analytical techniques include both targeted identification and quantification of metabolites and

Metrology for Multi-Physics AM Model Validation

Completed

Objective To provide reference data for the validation of multi-physics models of metal additive manufacturing processes to enable improvement of AM process models and more rapid and predictable process development for AM production by manufacturers. What is the Technical Idea? The Metrology for

Nanomaterial-containing Drug Classes graphic

Metrology for Nanomaterials in Medicine

Ongoing

Drug products that incorporate nanomaterials are defined by FDA as non-biological complex drugs (NBCDs). NBCDs are a class of medical products that cannot be defined nor fully identified as traditional small-molecule drugs. NBCDs consist of different components that form a complex hybrid structure

Metrology of the Ohm

Ongoing

The Metrology of the Ohm Project has been a leader in providing internationally consistent resistance standards that are readily available to support the scientific and industrial foundations of the U.S. economy. Through this very broad customer base, the activities of the project enable cost

Metrology for Real-Time Monitoring of Additive Manufacturing

Completed

Objective To develop and disseminate metrology methods, tools, data, and standards applied to in-situ monitoring of AM processes, such that manufacturers and their customers can accurately and precisely determine the quality of the fabrication process and resulting parts. What is the Technical Idea

Metrology and Standards for Canine Olfactory Detection of Explosives

Completed

Effective and accepted by the public, trained dogs are the most frequently deployed detection systems for identification of explosives threats in mobile applications. In addition to being highly sensitive, dogs can rapidly discriminate the unique profile of an explosive in a presence of a large

Microbial Cell Quantification Methods – Toward Whole Cell Reference Materials

Ongoing

Bacterial disaggregation as a strategy to improve cell counting ( S. Servetas, S. Da Silva) Counting bacterial cells is challenging enough when they are single, individual cells. It can be further complicated by the various bacterial morphologies (e.g., chains, clusters, etc.), which interfere with

Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing

Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are widely used and complementary analytical platforms for the characterization, identification, and quantification of a metabolome. MS techniques, typically coupled to chromatography, provide a chemical fingerprint of complex

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed

The MMQAP supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their

Mouse Allelic Ladder

Ongoing

What is an allelic ladder? An allelic ladder is a mixture of highly characterized alleles (known size and sequence) that are generated using the same primers as the test samples and are used during capillary electrophoresis for accurate allele call determination. Why is an allelic ladder important

Multi-Domain Knowledge Planes for Service Federation for 5G & Beyond Public Working Group (MDKP-PWG)

Ongoing

A. Problem Statement In the 5G and Beyond Era there are interesting growing trends on Requirements for Enablers for Cross-Industry Sectors End-to-End (E2E) Services Innovation and Delivery Agility and how to leverage dynamic resource and assets availability wherever and whenever so they can be

Nanotube Metrology

Completed

Single-wall carbon nanotubes (SWCNTs) are a tubular form of carbon consisting of a single shell of sp2 bonded carbon with a nanometer scale diameter that have many predicted properties superior to other available materials. However, every production technique for SWCNTs produces many different

Photograph of an automobile at an emissions testing station, with testing equipment and probe positioned at the car tailpipe.

New Gas Standard Reference Materials to Support the Automotive Industry

Completed

NIST currently supports AIGER members by maintaining reasonable inventories of required gas SRMs that consist of dilute mixtures of key pollutants such as carbon dioxide, carbon monoxide, hydrocarbons, and nitric oxide. Newer vehicles produce lower levels of these pollutants because their engines

NIST Automated Vehicles Program

Ongoing

Measurement science and standards are needed to support the safe and predictable operation of future automated vehicles (AVs), which have great potential to significantly impact our daily lives and improve the competitiveness of our economy. A FY22 NIST Strategic and Emerging Research Initiatives

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