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Projects/Programs

Keyword

Organizational Unit

This program encompasses multifaceted efforts to advance the metrology of climate science. Projects include: development of ultra-high accuracy optical standards and technologies to determine greenhouse gases (GHGs) concentrations, atmospheric lifetimes, and aerosol radiative forcing development of

Clinical and Forensic Reference Materials

Ongoing

Below is a listing of the reference materials currently produced by the Applied Genetics group. Clinical Diagnostics SRM 2393 - CAG Repeat Length Mutation in Huntington`s Disease SRM 2365 - BK Virus DNA Quantitative Standard SRM 2366a - Cytomegalovirus DNA (Towne Δ147 BAC) for DNA SRM 2367 - JC

Clinical Measurements Quality Assurance Program

Ongoing

The National Institute of Standards and Technology (NIST) established the Clinical Measurements Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. Participants measure concentrations of marker compounds, contaminants, metabolites in clinical samples (e.g

CODATA values of the fundamental physical constants

Ongoing

CODATA recommended values of the constants Database of references for data on the constants Publications: Reviews of Modern Physics ( 1998) ( 2002) ( 2006) ( 2010) ( 2014) Journal of Physical and Chemical Reference Data ( 1998) ( 2006) ( 2010) Resource Letter FC-1: The physics of fundamental

A Comparison of WD-EPMA Heterogeneity Testing Procedures

Ongoing

X-ray stage mapping (XSM) can be used to determine the extent of heterogeneity on the micron scale though it is more time consuming and not as accurate as the more rigorous NIST random-point (RP) testing procedure. The objective of this work is to demonstrate the advantage of the latter procedure

Comparisons: Key Comparison for Air-Kerma From Therapy Level and Radiation Protection Gamma-ray Beams

Completed

In support of the Mutual Recognition Arrangement of the International Committee for Weights and Measures (CIPM MRA), the Dosimetry Group of the Radiation Physics Division, PML has recently completed two key comparisons with the BIPM for therapy and radiation protection gamma-ray beams for the

Consistency Analysis and Uncertainty in ‘omic Data

Ongoing

‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate

Continuing Support of Cement Manufacturing

Ongoing

NIST SRMs for Portland cement and related materials are the de facto world standards for validation of analytical methods for testing of cement for compliance with manufacturing specifications and for qualification of laboratories throughout the supply chain, including cement plants, construction

Cover of the ASME International Steam Tables for Industrial Use, Third Edition

Contributions to International Standards on the Properties of Water

Ongoing

Water is probably the most widely used industrial fluid and it is important to have internationally accepted standards for its properties. This information is crucial to the analysis and design of thermal power cycles, as well as for climate studies including the hydrosphere. (Here is a summary of

5G Core Networks Testbed

Ongoing

This project, as part of our 6G Core and Edge Networks and Services Project, is building a 5G/6G Core Network Testbed— which we refer to as OpenCoreNet—to support research on sixth generation (6G) networks and to explore how 6G can best improve industry applications. OpenCoreNet focuses on core

Cryptographic Standards and Guidelines Development Process

Ongoing

For more information regarding the Cryptographic Standards and Guidelines Development Process, please visit the Computer Security Resource Center (CSRC).

Cyber Physical Systems and Internet of Things Program

Ongoing

Objective - Enable scalable, dependable design methods and reproducible performance measurement for effective and trustworthy (reliable, safe, secure, resilient and privacy-enhancing) cyber-physical systems and IoT, by means of new measurement science, advanced testing and assurance capabilities and

Cyber-Physical Systems/Internet of Things for Smart Cities

Ongoing

Objective - To provide the measurement science and standards-based foundations for interoperable, replicable, scalable, and trustworthy cyber-physical systems that can be readily and cost-effectively deployed by cities and communities of all types and sizes to improve their efficiency

Cyber-Physical Systems/Internet of Things Testbed

Ongoing

Objective - To develop general design principles useful to all cyber-physical systems testbed developers and the co-simulation community; to develop specific design concepts to guide the development, operation, and evolution of NIST’s IoT/CPS testbed; and to establish a cross-sector IoT/CPS testbed

Cyber-Physical Systems and Internet of Things Foundations

Ongoing

Objective - To provide a common technical and conceptual foundation for CPS and IoT that enables conceptualization, realization and assurance across all domains, including a comprehensive and traceable methodology for meeting all stakeholder concerns throughout any systems engineering process and

Data Driven Decision Support for Additive Manufacturing

Completed

Objective To develop and deploy the metrics, models, and best practices for using product definition, advanced analytics, and machine learning methods in additive manufacturing design and process planning to reduce lead times and support first-part-correct goals. Technical Idea Future advancements

Data Integration and Management for Additive Manufacturing

Completed

Objective Data plays the most critical role in linking AM lifecycle and value chain activities and streamlining the AM development process. While the AM data from a single build is essential for establishing part traceability, when methodically collected, the full processing history of thousands of

Data Science

Ongoing

Current MIG Data Science project activities DARPA D3M. NIST is supporting the DARPA D3M (Data-Driven Discoveries of Models) program as part of the Test and Evaluation (Government) Team. The D3M Program aims to allow automated systems with subject matter experts to model and solve complex machine

Department of Homeland Security Response Robot Performance Standards

Ongoing

The Intelligent Systems Division of the National Institute of Standards and Technology is conducting an ongoing project, sponsored by the Department of Homeland Security Science and Technology Directorate and the National Institute of Justice, to produce a comprehensive set of standard test methods

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

Ongoing

Research is ongoing to assess what information is required to validate films of collagen as reference extracellular matrix. During the first portion of this work we will develop protocols for characterizing the prototype collagen reference material with various instrumental techniques to develop

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is produced in the body after sun exposure and is also the form used in most fortified foods. Dietary supplements may contain either vitamin D2 or D3. Measurement of vitamin D in foods and dietary

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Kidney function can be evaluated by determining the glomerular filtration rate (GFR), which provides an estimate of how well the kidneys are removing waste and excess fluid from the blood. The GFR is not measured directly. Instead, a measurement of serum creatinine is performed, and this value is

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

The clinical measurement of serum cardiac troponin I (cTnI) has become one of the most important tools in the diagnosis of acute myocardial infarction and myocardial damage. Unfortunately, considerable variability in clinical cTnI assay results is observed when comparing assays from different

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

Reference measurement procedures and standard reference materials help ensure accuracy and comparability of routine clinical assays. In addition, this work allows U.S. clinical diagnostic manufacturers to comply with the European Union directive regarding in-vitro diagnostic medical devices (IVD MD)

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Steroid hormones and thyroid hormones serve an essential function by regulating gene transcription. Improving the accuracy of clinical assays for hormones will improve diagnoses and result in earlier treatments. Therefore, reference methods for the measurement of steroid and thyroid hormones have

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